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Scientific paper - Review paper
How far along are we in revealing the connection between metformin and colorectal cancer?
World Journal of Gastroenterology, 27 (2021), 14; 1362-1368. https://doi.org/10.3748/wjg.v27.i14.1362
Cigrovski Berković, Maja; Mikulić, Danko; Bilić-Ćurčić, Ines; Mrzljak, Anna

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Cigrovski Berković, M., Mikulić, D., Bilić Ćurčić, I. & Mrzljak, A. (2021). How far along are we in revealing the connection between metformin and colorectal cancer?. World Journal of Gastroenterology, 27. (14), 1362-1368. doi: 10.3748/wjg.v27.i14.1362

Cigrovski Berković, Maja, et al. "How far along are we in revealing the connection between metformin and colorectal cancer?." World Journal of Gastroenterology, vol. 27, no. 14, 2021, pp. 1362-1368. https://doi.org/10.3748/wjg.v27.i14.1362

Cigrovski Berković, Maja, Danko Mikulić, Ines Bilić Ćurčić and Anna Mrzljak. "How far along are we in revealing the connection between metformin and colorectal cancer?." World Journal of Gastroenterology 27, no. 14 (2021): 1362-1368. https://doi.org/10.3748/wjg.v27.i14.1362

Cigrovski Berković, M., et al. (2021) 'How far along are we in revealing the connection between metformin and colorectal cancer?', World Journal of Gastroenterology, 27(14), pp. 1362-1368. doi: 10.3748/wjg.v27.i14.1362

Cigrovski Berković M, Mikulić D, Bilić Ćurčić I, Mrzljak A. How far along are we in revealing the connection between metformin and colorectal cancer?. World Journal of Gastroenterology [Internet]. 2021 April 14 [cited 2024 November 22];27(14):1362-1368. doi: 10.3748/wjg.v27.i14.1362

M. Cigrovski Berković, D. Mikulić, I. Bilić Ćurčić and A. Mrzljak, "How far along are we in revealing the connection between metformin and colorectal cancer?", World Journal of Gastroenterology, vol. 27, no. 14, pp. 1362-1368, April 2021. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:547932. [Accessed: 22 November 2024]

Metadata
Title (english)How far along are we in revealing the connection between metformin and colorectal cancer?
AuthorMaja Cigrovski Berković
AuthorDanko Mikulić
AuthorInes Bilić-Ćurčić
AuthorAnna Mrzljak
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Internal Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (english)
Colorectal cancer (CRC) is among the most prevalent cancers worldwide, and its prevention and reduction of incidence is imperative. The presence of diabetes has been associated with a 30% increased risk of CRC, likely through the mechanism of hyperinsulinemia, which promotes tumorigenesis via the insulin receptor in the epithelium or by insulin-like growth factor pathways, inflammation, or adipokines, inducing cancer cell proliferation and cancer spread. Metformin, the first-line agent in treating type 2 diabetes, has a chemopreventive role in CRC development. Additionally, preclinical studies suggest synergistic effects of metformin with oxaliplatin in inhibiting in vitro models of colon cancer. Although preclinical studies on the post diagnostic use of metformin were promising and suggested its synergistic effects with chemotherapy, the data on the possible effects of metformin after surgery and other CRC treatment in the clinical setting are less conclusive, and randomized controlled trials are still lacking.
Keywords (english)
Languageenglish
Publication typeScientific paper - Review paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleWorld Journal of Gastroenterology
Numberingvol. 27, no. 14, pp. 1362-1368
p-ISSN1007-9327
e-ISSN2219-2840
DOIhttps://doi.org/10.3748/wjg.v27.i14.1362
URN:NBNurn:nbn:hr:105:547932
Publication2021-04-14
Document URLhttps://www.wjgnet.com/1007-9327/full/v27/i14/1362.htm
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) icon
Created on2021-10-15 07:51:05