prikaz prve stranice dokumenta Lymphocytic Choriomeningitis—Emerging Trends of a Neglected Virus: A Narrative Review
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Scientific paper - Review paper
Lymphocytic Choriomeningitis—Emerging Trends of a Neglected Virus: A Narrative Review
Tropical Medicine and Infectious Disease, 6 (2021), 2; 88. https://doi.org/10.3390/tropicalmed6020088
Vilibić-Čavlek, Tatjana; Savić, Vladimir; Ferenc, Thomas; Mrzljak, Anna; Barbić, Ljubo; Bogdanić, Maja; Stevanović, Vladimir; Tabain, Irena; Ferenčak, Ivana; Židovec-Lepej, Snježana

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Vilibić Čavlek, T., Savić, V., Ferenc, T., Mrzljak, A., Barbić, Lj., Bogdanić, M. ... Židovec Lepej, S. (2021). Lymphocytic Choriomeningitis—Emerging Trends of a Neglected Virus: A Narrative Review. Tropical Medicine and Infectious Disease, 6. (2). doi: 10.3390/tropicalmed6020088

Vilibić Čavlek, Tatjana, et al. "Lymphocytic Choriomeningitis—Emerging Trends of a Neglected Virus: A Narrative Review." Tropical Medicine and Infectious Disease, vol. 6, no. 2, 2021. https://doi.org/10.3390/tropicalmed6020088

Vilibić Čavlek, Tatjana, Vladimir Savić, Thomas Ferenc, Anna Mrzljak, Ljubo Barbić, Maja Bogdanić, Vladimir Stevanović, Irena Tabain, Ivana Ferenčak and Snježana Židovec Lepej. "Lymphocytic Choriomeningitis—Emerging Trends of a Neglected Virus: A Narrative Review." Tropical Medicine and Infectious Disease 6, no. 2 (2021). https://doi.org/10.3390/tropicalmed6020088

Vilibić Čavlek, T., et al. (2021) 'Lymphocytic Choriomeningitis—Emerging Trends of a Neglected Virus: A Narrative Review', Tropical Medicine and Infectious Disease, 6(2). doi: 10.3390/tropicalmed6020088

Vilibić Čavlek T, Savić V, Ferenc T, Mrzljak A, Barbić Lj, Bogdanić M, and sur.. Lymphocytic Choriomeningitis—Emerging Trends of a Neglected Virus: A Narrative Review. Tropical Medicine and Infectious Disease [Internet]. 2021 May 25 [cited 2024 November 26];6(2). doi: 10.3390/tropicalmed6020088

T. Vilibić Čavlek, et al., "Lymphocytic Choriomeningitis—Emerging Trends of a Neglected Virus: A Narrative Review", Tropical Medicine and Infectious Disease, vol. 6, no. 2, May 2021. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:818110. [Accessed: 26 November 2024]

Metadata
Title (english)Lymphocytic Choriomeningitis—Emerging Trends of a Neglected Virus: A Narrative Review
AuthorTatjana Vilibić-Čavlek
AuthorVladimir Savić
AuthorThomas Ferenc
AuthorAnna Mrzljak
AuthorLjubo Barbić
AuthorMaja Bogdanić
AuthorVladimir Stevanović
AuthorIrena Tabain
AuthorIvana Ferenčak
AuthorSnježana Židovec-Lepej
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Internal Medicine)
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Medical Microbiology and Parasitology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Medical Microbiology
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (english)
Lymphocytic choriomeningitis virus (LCMV) is a neglected rodent-borne zoonotic virus distributed worldwide. Since serologic assays are limited to several laboratories, the disease has been underreported, often making it difficult to determine incidence and seroprevalence rates. Although human clinical cases are rarely recorded, LCMV remains an important cause of meningitis in humans. In addition, a fatal donor-derived LCMV infection in several clusters of solid organ transplant recipients further highlighted a pathogenic potential and clinical significance of this virus. In the transplant populations, abnormalities of the central nervous system were also found, but were overshadowed by the systemic illness resembling the Lassa hemorrhagic fever. LCMV is also an emerging fetal teratogen. Hydrocephalus, periventricular calcifications and chorioretinitis are the predominant characteristics of congenital LCMV infection, occurring in 87.5% of cases. Mortality in congenitally infected children is about 35%, while 70% of them show long-term neurologic sequelae. Clinicians should be aware of the risks posed by LCMV and should consider the virus in the differential diagnosis of aseptic meningitis, especially in patients who reported contact with rodents. Furthermore, LCMV should be considered in infants and children with unexplained hydrocephalus, intracerebral calcifications and chorioretinitis. Despite intensive interdisciplinary research efforts, efficient antiviral therapy for LCMV infection is still not available.
Keywords (english)
Languageenglish
Publication typeScientific paper - Review paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleTropical Medicine and Infectious Disease
Numberingvol. 6, no. 2, 88
e-ISSN2414-6366
DOIhttps://doi.org/10.3390/tropicalmed6020088
URN:NBNurn:nbn:hr:105:818110
Publication2021-05-25
Document URLhttps://www.mdpi.com/2414-6366/6/2/88
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2021-11-04 09:07:41