prikaz prve stranice dokumenta Fundamentals of the Development of Connectivity in the Human Fetal Brain in Late Gestation: From 24 Weeks Gestational Age to Term
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Scientific paper - Original scientific paper
Fundamentals of the Development of Connectivity in the Human Fetal Brain in Late Gestation: From 24 Weeks Gestational Age to Term
Journal of Neuropathology & Experimental Neurology, 80 (2021), 5; 393-414. https://doi.org/10.1093/jnen/nlab024
Kostović, Ivica; Radoš, Milan; Kostović-Srzentić, Mirna; Krsnik, Željka

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Kostović, I., Radoš, M., Kostović Srzentić, M. & Krsnik, Ž. (2021). Fundamentals of the Development of Connectivity in the Human Fetal Brain in Late Gestation: From 24 Weeks Gestational Age to Term. Journal of Neuropathology & Experimental Neurology, 80. (5), 393-414. doi: 10.1093/jnen/nlab024

Kostović, Ivica, et al. "Fundamentals of the Development of Connectivity in the Human Fetal Brain in Late Gestation: From 24 Weeks Gestational Age to Term." Journal of Neuropathology & Experimental Neurology, vol. 80, no. 5, 2021, pp. 393-414. https://doi.org/10.1093/jnen/nlab024

Kostović, Ivica, Milan Radoš, Mirna Kostović Srzentić and Željka Krsnik. "Fundamentals of the Development of Connectivity in the Human Fetal Brain in Late Gestation: From 24 Weeks Gestational Age to Term." Journal of Neuropathology & Experimental Neurology 80, no. 5 (2021): 393-414. https://doi.org/10.1093/jnen/nlab024

Kostović, I., et al. (2021) 'Fundamentals of the Development of Connectivity in the Human Fetal Brain in Late Gestation: From 24 Weeks Gestational Age to Term', Journal of Neuropathology & Experimental Neurology, 80(5), pp. 393-414. doi: 10.1093/jnen/nlab024

Kostović I, Radoš M, Kostović Srzentić M, Krsnik Ž. Fundamentals of the Development of Connectivity in the Human Fetal Brain in Late Gestation: From 24 Weeks Gestational Age to Term. Journal of Neuropathology & Experimental Neurology [Internet]. 2021 April 16 [cited 2024 December 24];80(5):393-414. doi: 10.1093/jnen/nlab024

I. Kostović, M. Radoš, M. Kostović Srzentić and Ž. Krsnik, "Fundamentals of the Development of Connectivity in the Human Fetal Brain in Late Gestation: From 24 Weeks Gestational Age to Term", Journal of Neuropathology & Experimental Neurology, vol. 80, no. 5, pp. 393-414, April 2021. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:020579. [Accessed: 24 December 2024]

Metadata
Title (english)Fundamentals of the Development of Connectivity in the Human Fetal Brain in Late Gestation: From 24 Weeks Gestational Age to Term
AuthorIvica Kostović
AuthorMilan Radoš
AuthorMirna Kostović-Srzentić
AuthorŽeljka Krsnik
Author's institutionUniversity of Zagreb
School of Medicine
(Croatian Institiute for Brain Research)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Neuroscience
Abstract (english)
During the second half of gestation, the human cerebrum undergoes pivotal histogenetic events that underlie functional connectivity. These include the growth, guidance, selection of axonal pathways, and their first engagement in neuronal networks. Here, we characterize the spatiotemporal patterns of cerebral connectivity in extremely preterm (EPT), very preterm (VPT), preterm and term babies, focusing on magnetic resonance imaging (MRI) and histological data. In the EPT and VPT babies, thalamocortical axons enter into the cortical plate creating the electrical synapses. Additionally, the subplate zone gradually resolves in the preterm and term brain in conjunction with the growth of associative pathways leading to the activation of large-scale neural networks. We demonstrate that specific classes of axonal pathways within cerebral compartments are selectively vulnerable to temporally nested pathogenic factors. In particular, the radial distribution of axonal lesions, that is, radial vulnerability, is a robust predictor of clinical outcome. Furthermore, the subplate tangential nexus that we can visualize using MRI could be an additional marker as pivotal in the development of cortical connectivity. We suggest to direct future research toward the identification of sensitive markers of earlier lesions, the elucidation of genetic mechanisms underlying pathogenesis, and better long-term follow-up using structural and functional MRI.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleJournal of Neuropathology & Experimental Neurology
Numberingvol. 80, no. 5, pp. 393-414
p-ISSN0022-3069
e-ISSN1554-6578
DOIhttps://doi.org/10.1093/jnen/nlab024
URN:NBNurn:nbn:hr:105:020579
Publication2021-04-16
Document URLhttps://academic.oup.com/jnen/article/80/5/393/6212242
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) icon
Created on2021-11-26 11:43:09