prikaz prve stranice dokumenta Impact of age on the cumulative risk of transformation in patients with chronic myelomonocytic leukaemia
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Scientific paper - Original scientific paper
Impact of age on the cumulative risk of transformation in patients with chronic myelomonocytic leukaemia
European Journal of Haematology, 107 (2021), 2; 265-274. https://doi.org/10.1111/ejh.13647
Machherndl‐Spandl, Sigrid; Jäger, Eva; Barna, Agnes; Gurbisz, Michael; Marschon, Renate; Graf, Temeida; Graf, Elmir; Geissler, Christoph; Hoermann, Gregor; Nösslinger, Thomas; Pfeilstöcker, Michael; Bettelheim, Peter; Zach, Otto; Weltermann, Ansgar; Heibl, Sonja; Thaler, Josef; Zebisch, Armin; Sill, Heinz; Stauder, Reinhard; Webersinke, Gerald; Kušec, Rajko; Ulsperger, Ernst; Schneeweiss, Bruno; Öhler, Leopold; Germing, Ulrich; Valent, Peter; Tüchler, Heinz; Geissler, Klaus More authors...

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Machherndl‐Spandl, S., Jäger, E., Barna, A., Gurbisz, M., Marschon, R., Graf, T. ... Geissler, K. (2021). Impact of age on the cumulative risk of transformation in patients with chronic myelomonocytic leukaemia. European Journal of Haematology, 107. (2), 265-274. doi: 10.1111/ejh.13647

Machherndl‐Spandl, Sigrid, et al. "Impact of age on the cumulative risk of transformation in patients with chronic myelomonocytic leukaemia." European Journal of Haematology, vol. 107, no. 2, 2021, pp. 265-274. https://doi.org/10.1111/ejh.13647

Machherndl‐Spandl, Sigrid, Eva Jäger, Agnes Barna, Michael Gurbisz, Renate Marschon, Temeida Graf, Elmir Graf, et al. "Impact of age on the cumulative risk of transformation in patients with chronic myelomonocytic leukaemia." European Journal of Haematology 107, no. 2 (2021): 265-274. https://doi.org/10.1111/ejh.13647

Machherndl‐Spandl, S., et al. (2021) 'Impact of age on the cumulative risk of transformation in patients with chronic myelomonocytic leukaemia', European Journal of Haematology, 107(2), pp. 265-274. doi: 10.1111/ejh.13647

Machherndl‐Spandl S, Jäger E, Barna A, Gurbisz M, Marschon R, Graf T, and sur.. Impact of age on the cumulative risk of transformation in patients with chronic myelomonocytic leukaemia. European Journal of Haematology [Internet]. 2021 August [cited 2024 November 22];107(2):265-274. doi: 10.1111/ejh.13647

S. Machherndl‐Spandl, et al., "Impact of age on the cumulative risk of transformation in patients with chronic myelomonocytic leukaemia", European Journal of Haematology, vol. 107, no. 2, pp. 265-274, August 2021. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:108756. [Accessed: 22 November 2024]

Metadata
Title (english)Impact of age on the cumulative risk of transformation in patients with chronic myelomonocytic leukaemia
AuthorSigrid Machherndl‐Spandl
AuthorEva Jäger
AuthorAgnes Barna
AuthorMichael Gurbisz
AuthorRenate Marschon
AuthorTemeida Graf
AuthorElmir Graf
AuthorChristoph Geissler
AuthorGregor Hoermann
AuthorThomas Nösslinger
AuthorMichael Pfeilstöcker
AuthorPeter Bettelheim
AuthorOtto Zach
AuthorAnsgar Weltermann
AuthorSonja Heibl
AuthorJosef Thaler
AuthorArmin Zebisch
AuthorHeinz Sill
AuthorReinhard Stauder
AuthorGerald Webersinke
AuthorRajko Kušec
AuthorErnst Ulsperger
AuthorBruno Schneeweiss
AuthorLeopold Öhler
AuthorUlrich Germing
AuthorPeter Valent
AuthorHeinz Tüchler
AuthorKlaus Geissler
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Internal Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (english)
In older patients with chronic myelomonocytic leukaemia (CMML) and limited life expectancy due to age and or comorbidities, it is particularly important to consider the risk of transformation for individualised treatment decisions. There is limited information on potential differences between younger and older CMML patients regarding the cumulative risk of transformation as well as haematological, molecular and biologic characteristics. We analysed data from the Austrian Biodatabase for CMML (ABCMML) to compare these parameters in 518 CMML patients. Categorisation of patients into 3 age-related groups: <60 years, 60-79 years and ≥80 years, showed a significantly lower risk of transformation at higher age by competing risk analysis, with a 4-year risk of 39%, 23% and 13%, respectively (P < .0001). The lower probability of transformation was associated with a lower percentage of blast cells in the peripheral blood (PB) of older patients. Furthermore, we provide a simple score based on age, PB blasts and platelet counts that allowed us to define subgroups of CMML patients with a different cumulative transformation risk, including a low-risk group with a transformation risk of only 5%. Our findings may facilitate reasonable treatment decisions in elderly patients with CMML.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleEuropean Journal of Haematology
Numberingvol. 107, no. 2, pp. 265-274
p-ISSN0902-4441
e-ISSN1600-0609
DOIhttps://doi.org/10.1111/ejh.13647
URN:NBNurn:nbn:hr:105:108756
Publication2021-08
Document URLhttps://onlinelibrary.wiley.com/doi/10.1111/ejh.13647
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2022-01-10 10:33:05