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master's thesis
Secondary hyperparathyroidism
update on pathogenesis, diagnosis and treatment
Zagreb: University of Zagreb, School of Medicine, 2015. urn:nbn:hr:105:426623
Ivančić, Stipe
University of Zagreb
School of Medicine

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Ivančić, S. (2015). Secondary hyperparathyroidism : update on pathogenesis, diagnosis and treatment (Master's thesis). Zagreb: University of Zagreb, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:426623

Ivančić, Stipe. "Secondary hyperparathyroidism : update on pathogenesis, diagnosis and treatment." Master's thesis, University of Zagreb, School of Medicine, 2015. https://urn.nsk.hr/urn:nbn:hr:105:426623

Ivančić, Stipe. "Secondary hyperparathyroidism : update on pathogenesis, diagnosis and treatment." Master's thesis, University of Zagreb, School of Medicine, 2015. https://urn.nsk.hr/urn:nbn:hr:105:426623

Ivančić, S. (2015). 'Secondary hyperparathyroidism : update on pathogenesis, diagnosis and treatment', Master's thesis, University of Zagreb, School of Medicine, accessed 26 November 2024, https://urn.nsk.hr/urn:nbn:hr:105:426623

Ivančić S. Secondary hyperparathyroidism : update on pathogenesis, diagnosis and treatment [Master's thesis]. Zagreb: University of Zagreb, School of Medicine; 2015 [cited 2024 November 26] Available at: https://urn.nsk.hr/urn:nbn:hr:105:426623

S. Ivančić, "Secondary hyperparathyroidism : update on pathogenesis, diagnosis and treatment", Master's thesis, University of Zagreb, School of Medicine, Zagreb, 2015. Available at: https://urn.nsk.hr/urn:nbn:hr:105:426623

Metadata
TitleSecondary hyperparathyroidism : update on pathogenesis, diagnosis and treatment
AuthorStipe Ivančić
MentorDraško Pavlović (mentor)
Committee memberDraško Pavlović (predsjednik povjerenstva)
Committee memberBoško Skorić (član povjerenstva)
Committee memberDarko Kaštelan (član povjerenstva)
GranterUniversity of Zagreb
School of Medicine
Zagreb
Defense date and country2015-09-25, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract
Secondary hyperparathyroidism is a frequently encountered problem in the management of patients with chronic kidney disease (CKD). Its pathophysiology is mainly due to hyperphosphatemia, vitamin D deficiency and resistance. Resistance in the form of downregulation in parathyroid vitamin D and calcium-sensing receptors represent critical steps in pathogenesis. Eventually abnormalities in mineral phosphate, calcium, and vitamin D begin to appear. Lack of control of serum PTH and associated minerals result in bone pathologies and vascular calcification. This condition has a high impact on the mortality and morbidity of dialysis patients. Early diagnosis of secondary hyperparathyroidism is crucial in the management of patients with CKD. Achieving current targets for the key mineral parameters in the management of SHPT set by the Kidney Disease Improving Global Outcomes (KDIGO) guidelines can be challenging. This review summarizes the current understanding and evidence supporting strategies for SHPT treatment in CKD patients. Treatment should include a combination of dietary phosphorus restriction, phosphate binders, vitamin D sterols, and calcimimetics. Parathyroidectomy is effective in suitable candidates’ refractory to medical therapy and the standard against which new approaches should be measured.
Keywords
Languageenglish
URN:NBNurn:nbn:hr:105:426623
Study programmeTitle: Medicine (in English language)
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2015-12-09 12:00:45