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master's thesis
Intranazalna primjena inzulina kao terapijski pristup u liječenju Alzheimerove bolesti
Zagreb: University of Zagreb, School of Medicine, 2021. urn:nbn:hr:105:098193
Buljan, Bruno
University of Zagreb
School of Medicine
Department of Pharmacology

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

Cite this document

Buljan, B. (2021). Intranazalna primjena inzulina kao terapijski pristup u liječenju Alzheimerove bolesti (Master's thesis). Zagreb: University of Zagreb, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:098193

Buljan, Bruno. "Intranazalna primjena inzulina kao terapijski pristup u liječenju Alzheimerove bolesti." Master's thesis, University of Zagreb, School of Medicine, 2021. https://urn.nsk.hr/urn:nbn:hr:105:098193

Buljan, Bruno. "Intranazalna primjena inzulina kao terapijski pristup u liječenju Alzheimerove bolesti." Master's thesis, University of Zagreb, School of Medicine, 2021. https://urn.nsk.hr/urn:nbn:hr:105:098193

Buljan, B. (2021). 'Intranazalna primjena inzulina kao terapijski pristup u liječenju Alzheimerove bolesti', Master's thesis, University of Zagreb, School of Medicine, accessed 27 December 2024, https://urn.nsk.hr/urn:nbn:hr:105:098193

Buljan B. Intranazalna primjena inzulina kao terapijski pristup u liječenju Alzheimerove bolesti [Master's thesis]. Zagreb: University of Zagreb, School of Medicine; 2021 [cited 2024 December 27] Available at: https://urn.nsk.hr/urn:nbn:hr:105:098193

B. Buljan, "Intranazalna primjena inzulina kao terapijski pristup u liječenju Alzheimerove bolesti", Master's thesis, University of Zagreb, School of Medicine, Zagreb, 2021. Available at: https://urn.nsk.hr/urn:nbn:hr:105:098193

Metadata
TitleIntranazalna primjena inzulina kao terapijski pristup u liječenju Alzheimerove bolesti
Title (english)Intranasal insulin as a therapeutic strategy in the treatment of Alzheimer's disease
AuthorBruno Buljan
MentorMelita Šalković-Petrišić (mentor)
Committee memberNinoslav Mimica (predsjednik povjerenstva)
Committee memberJasenka Markeljević (član povjerenstva)
Committee memberMelita Šalković-Petrišić (član povjerenstva)
GranterUniversity of Zagreb
School of Medicine
(Department of Pharmacology)
Zagreb
Defense date and country2021-09-11, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Pharmacology
Abstract
Alzheimerova bolest je neurodegeneraivna bolest sa značajnim ekonomskim i socijalnim učinkom na društvo. Do danas ne postoji sigurna teorija nastanka Alzheimerove bolesti niti značajno učinkovita terapija za Alzheimerovu bolest. Ovaj diplomski rad obrađuje mogućnosti intranazalne primjene inzulina kao potencijalnog budućeg terapijskog riješenja kroz tri dijela. U prvome dijelu je prikazana epidemiologija, klinička slika, patologija, patogeneza i odobrena terapija Alzheimerove bolesti; u drugome dijelu centralna inzulinska rezistencija kao moguća osnova patogeneze Alzheimerove bolesti i mehanicistički susptrat učinka intranazalno primjenjenog inzulina na razvoj i progresiju Alzheimerove bolesti; a u trećem dijelu pretklinička i klinička istraživanja intranazalne primjene inzulina s porukom o učinkovitosti, sigurnosti i ograničenjima predložene terapije za Alzheimerovu bolest.
Abstract (english)
Alzheimer's disease is a neurodegenerative disease with a significant economic and social impact on society. To date, there is no reliable theory of Alzheimer's disease pathogenesis or significantly effective therapy for Alzheimer's disease. This thesis deals with the possibilities of intranasal administration of insulin as a potential future therapeutic solution through three parts. The first part presents the epidemiology, clinical picture, pathology, pathogenesis and approved therapy of Alzheimer's disease; in the second part, central insulin resistance as a possible basis for the pathogenesis of Alzheimer's disease and a mechanistic substrate of the effect of intranasally administered insulin on the development and progression of Alzheimer's disease is elaborated; and in the third part, preclinical and clinical studies of intranasal insulin administration are listed with a message about the efficacy, safety, and limitations of the proposed therapy for Alzheimer’s disease.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:105:098193
Study programmeTitle: Medicine
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2022-01-28 11:37:29