prikaz prve stranice dokumenta Immunohistochemical Expression of Wnt-4 Protein in Clear Cell Renal Carcinoma
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Scientific paper - Original scientific paper
Immunohistochemical Expression of Wnt-4 Protein in Clear Cell Renal Carcinoma
Journal of Clinical Medicine, 10 (2021), 24; 5795. https://doi.org/10.3390/jcm10245795
Pavlović, Oliver; Hudolin, Tvrtko; Miškulin, Ivan; Bulimbašić, Stela; Ćorić, Marijana; Perković, Josip; Zekulić, Toni

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Pavlović, O., Hudolin, T., Miškulin, I., Bulimbašić, S., Ćorić, M., Perković, J. & Zekulić, T. (2021). Immunohistochemical Expression of Wnt-4 Protein in Clear Cell Renal Carcinoma. Journal of Clinical Medicine, 10. (24). doi: 10.3390/jcm10245795

Pavlović, Oliver, et al. "Immunohistochemical Expression of Wnt-4 Protein in Clear Cell Renal Carcinoma." Journal of Clinical Medicine, vol. 10, no. 24, 2021. https://doi.org/10.3390/jcm10245795

Pavlović, Oliver, Tvrtko Hudolin, Ivan Miškulin, Stela Bulimbašić, Marijana Ćorić, Josip Perković and Toni Zekulić. "Immunohistochemical Expression of Wnt-4 Protein in Clear Cell Renal Carcinoma." Journal of Clinical Medicine 10, no. 24 (2021). https://doi.org/10.3390/jcm10245795

Pavlović, O., et al. (2021) 'Immunohistochemical Expression of Wnt-4 Protein in Clear Cell Renal Carcinoma', Journal of Clinical Medicine, 10(24). doi: 10.3390/jcm10245795

Pavlović O, Hudolin T, Miškulin I, Bulimbašić S, Ćorić M, Perković J, and sur.. Immunohistochemical Expression of Wnt-4 Protein in Clear Cell Renal Carcinoma. Journal of Clinical Medicine [Internet]. 2021 December 11 [cited 2024 November 22];10(24). doi: 10.3390/jcm10245795

O. Pavlović, et al., "Immunohistochemical Expression of Wnt-4 Protein in Clear Cell Renal Carcinoma", Journal of Clinical Medicine, vol. 10, no. 24, December 2021. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:994891. [Accessed: 22 November 2024]

Metadata
Title (english)Immunohistochemical Expression of Wnt-4 Protein in Clear Cell Renal Carcinoma
AuthorOliver Pavlović
AuthorTvrtko Hudolin
AuthorIvan Miškulin
AuthorStela Bulimbašić
AuthorMarijana Ćorić
AuthorJosip Perković
AuthorToni Zekulić
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Pathology)
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Urology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Pathology
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Urology
Abstract (english)
Wingless binding integration site proteins (Wnt) have an important role in normal kidney development and in various kidney diseases. They are required for complete epithelial differentiation and normal nephron formation. Changes in these proteins could also have important role in carcinogenesis. This study included 185 patients with clear cell renal carcinoma (ccRCC) in whom immunohistochemical expression of Wnt-4 protein in healthy and tumorous tissue after surgery was investigated. There was higher expression of Wnt-4 in healthy than in tumor tissue. No difference between Fuhrman’s grade and Wnt-4 expression was found. A poor negative correlation between tumor size and Wnt-4 expression was found. Patients with suspected metastatic diseases had higher Wnt-4 expression. There was no difference in survival rates between Wnt-4 negative and positive groups. In our study we have shown that high Wnt-4 expression in healthy tissue decreases in low-grade tumors but then increases in high-grade tumors, suggesting that tumor progression requires Wnt-4 activation or reactivation.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleJournal of Clinical Medicine
Numberingvol. 10, no. 24, 5795
e-ISSN2077-0383
DOIhttps://doi.org/10.3390/jcm10245795
URN:NBNurn:nbn:hr:105:994891
Publication2021-12-11
Document URLhttps://www.mdpi.com/2077-0383/10/24/5795
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2022-02-01 09:44:02