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Scientific paper - Original scientific paper
Epigenetically inactivated RASSF1A as a tumor biomarker
Bosnian Journal of Basic Medical Sciences, 21 (2021), 4; 386-397. https://doi.org/10.17305/bjbms.2020.5219
Raos, Dora; Ulamec, Monika; Katušić Bojanac, Ana; Bulić-Jakuš, Floriana; Ježek, Davor; Sinčić, Nino

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Raos, D., Ulamec, M., Katušić Bojanac, A., Bulić Jakuš, F., Ježek, D. & Sinčić, N. (2021). Epigenetically inactivated RASSF1A as a tumor biomarker. Bosnian Journal of Basic Medical Sciences, 21. (4), 386-397. doi: 10.17305/bjbms.2020.5219

Raos, Dora, et al. "Epigenetically inactivated RASSF1A as a tumor biomarker." Bosnian Journal of Basic Medical Sciences, vol. 21, no. 4, 2021, pp. 386-397. https://doi.org/10.17305/bjbms.2020.5219

Raos, Dora, Monika Ulamec, Ana Katušić Bojanac, Floriana Bulić Jakuš, Davor Ježek and Nino Sinčić. "Epigenetically inactivated RASSF1A as a tumor biomarker." Bosnian Journal of Basic Medical Sciences 21, no. 4 (2021): 386-397. https://doi.org/10.17305/bjbms.2020.5219

Raos, D., et al. (2021) 'Epigenetically inactivated RASSF1A as a tumor biomarker', Bosnian Journal of Basic Medical Sciences, 21(4), pp. 386-397. doi: 10.17305/bjbms.2020.5219

Raos D, Ulamec M, Katušić Bojanac A, Bulić Jakuš F, Ježek D, Sinčić N. Epigenetically inactivated RASSF1A as a tumor biomarker. Bosnian Journal of Basic Medical Sciences [Internet]. 2021 August 01 [cited 2024 December 28];21(4):386-397. doi: 10.17305/bjbms.2020.5219

D. Raos, M. Ulamec, A. Katušić Bojanac, F. Bulić Jakuš, D. Ježek and N. Sinčić, "Epigenetically inactivated RASSF1A as a tumor biomarker", Bosnian Journal of Basic Medical Sciences, vol. 21, no. 4, pp. 386-397, August 2021. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:567170. [Accessed: 28 December 2024]

Metadata
Title (english)Epigenetically inactivated RASSF1A as a tumor biomarker
AuthorDora Raos
AuthorMonika Ulamec
AuthorAna Katušić Bojanac
AuthorFloriana Bulić-Jakuš
AuthorDavor Ježek
AuthorNino Sinčić
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Histology and Embryology)
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Medical Biology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Cytology, Histology and Embryology
Abstract (english)
RASSF1A, one of the eight isoforms of the RASSF1 gene, is a tumor suppressor gene that influences tumor initiation and development. In cancer, RASSF1A is frequently inactivated by mutations, loss of heterozygosity, and, most commonly, by promoter hypermethylation. Epigenetic inactivation of RASSF1A was detected in various cancer types and led to significant interest; current research on RASSF1A promoter methylation focuses on its roles as an epigenetic tumor biomarker. Typically, researchers analyzed genomic DNA (gDNA) to measure the amount of RASSF1A promoter methylation. Cell-free DNA (cfDNA) from liquid biopsies is a recent development showing promise as an early cancer diagnostic tool using biomarkers, such as RASSF1A. This review discusses the evidence on aberrantly methylated RASSF1A in gDNA and cfDNA from different cancer types and its utility for early cancer diagnosis, prognosis, and surveillance. We compared methylation frequencies of RASSF1A in gDNA and cfDNA in various cancer types. The weaknesses and strengths of these analyses are discussed. In conclusion, although the importance of RASSSF1A methylation to cancer has been established is included in several diagnostic panels, its diagnostic utility is still experimental.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleBosnian Journal of Basic Medical Sciences
Numberingvol. 21, no. 4, pp. 386-397
p-ISSN1512-8601
e-ISSN1840-4812
DOIhttps://doi.org/10.17305/bjbms.2020.5219
URN:NBNurn:nbn:hr:105:567170
Publication2021-08-01
Document URLhttps://www.bjbms.org/ojs/index.php/bjbms/article/view/5219
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2022-02-04 10:42:23