prikaz prve stranice dokumenta Leydig Cells in Patients with Non-Obstructive Azoospermia: Do They Really Proliferate?
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Scientific paper - Original scientific paper
Leydig Cells in Patients with Non-Obstructive Azoospermia: Do They Really Proliferate?
Life, 11 (2021), 11; 1266. https://doi.org/10.3390/life11111266
Hauptman, Dinko; Himelreich Perić, Marta; Marić, Tihana; Katušić Bojanac, Ana; Sinčić, Nino; Zimak, Zoran; Kaštelan, Željko; Ježek, Davor

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Hauptman, D., Himelreich Perić, M., Marić, T., Katušić Bojanac, A., Sinčić, N., Zimak, Z. ... Ježek, D. (2021). Leydig Cells in Patients with Non-Obstructive Azoospermia: Do They Really Proliferate?. Life, 11. (11). doi: 10.3390/life11111266

Hauptman, Dinko, et al. "Leydig Cells in Patients with Non-Obstructive Azoospermia: Do They Really Proliferate?." Life, vol. 11, no. 11, 2021. https://doi.org/10.3390/life11111266

Hauptman, Dinko, Marta Himelreich Perić, Tihana Marić, Ana Katušić Bojanac, Nino Sinčić, Zoran Zimak, Željko Kaštelan and Davor Ježek. "Leydig Cells in Patients with Non-Obstructive Azoospermia: Do They Really Proliferate?." Life 11, no. 11 (2021). https://doi.org/10.3390/life11111266

Hauptman, D., et al. (2021) 'Leydig Cells in Patients with Non-Obstructive Azoospermia: Do They Really Proliferate?', Life, 11(11). doi: 10.3390/life11111266

Hauptman D, Himelreich Perić M, Marić T, Katušić Bojanac A, Sinčić N, Zimak Z, and sur.. Leydig Cells in Patients with Non-Obstructive Azoospermia: Do They Really Proliferate?. Life [Internet]. 2021 November 19 [cited 2024 November 08];11(11). doi: 10.3390/life11111266

D. Hauptman, et al., "Leydig Cells in Patients with Non-Obstructive Azoospermia: Do They Really Proliferate?", Life, vol. 11, no. 11, November 2021. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:510919. [Accessed: 08 November 2024]

Metadata
Title (english)Leydig Cells in Patients with Non-Obstructive Azoospermia: Do They Really Proliferate?
AuthorDinko Hauptman
AuthorMarta Himelreich Perić
AuthorTihana Marić
AuthorAna Katušić Bojanac
AuthorNino Sinčić
AuthorZoran Zimak
AuthorŽeljko Kaštelan
AuthorDavor Ježek
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Histology and Embryology)
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Medical Biology)
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Urology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Cytology, Histology and Embryology
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Urology
Abstract (english)
Background: Non-obstructive azoospermia (NOA) is a form of male infertility caused by disorders of the testicular parenchyma and impaired spermatogenesis. This study aimed to investigate the nature of Leydig cell changes in patients with NOA, especially whether their actual proliferation occurred. ----- Methods: 48 testicular biopsies from infertile patients with NOA and 24 testicular biopsies originating from azoospermic patients suffering from obstructive azoospermia (OA) were included in the study. Leydig cells and their possible proliferative activity were analysed by immunohistochemistry and morphometry (stereology). ----- Results: Unlike in the OA group, Leydig cells in NOA patients were sometimes organised into larger clusters and displayed an abundant cytoplasm/hypertrophy. Moreover, significant fibrosis of the interstitial compartment was demonstrated in some NOA samples, often accompanied by inflammatory cells. Stereological analysis showed no increase/proliferation of Leydig cells; on the contrary, these cells decreased in number in the NOA group. ----- Conclusions: The decrease in the number of Leydig cells can be explained by previous inflammatory changes within the testicular interstitium and consequent interstitial fibrosis. The interstitial fibrosis might have a deteriorating effect on Leydig cells.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleLife
Numberingvol. 11, no. 11, 1266
e-ISSN2075-1729
DOIhttps://doi.org/10.3390/life11111266
URN:NBNurn:nbn:hr:105:510919
Publication2021-11-19
Document URLhttps://www.mdpi.com/2075-1729/11/11/1266
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2022-03-01 09:39:05