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master's thesis
Povezanost psihijatrijskih poremećaja i metabolizma nezasićenih masnih kiselina
Zagreb: University of Zagreb, School of Medicine, 2021. urn:nbn:hr:105:520472
Mihaljević, Ivana
University of Zagreb
School of Medicine
Department of Medical Chemistry, Biochemistry and Clinical Chemistry

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Mihaljević, I. (2021). Povezanost psihijatrijskih poremećaja i metabolizma nezasićenih masnih kiselina (Master's thesis). Zagreb: University of Zagreb, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:520472

Mihaljević, Ivana. "Povezanost psihijatrijskih poremećaja i metabolizma nezasićenih masnih kiselina." Master's thesis, University of Zagreb, School of Medicine, 2021. https://urn.nsk.hr/urn:nbn:hr:105:520472

Mihaljević, Ivana. "Povezanost psihijatrijskih poremećaja i metabolizma nezasićenih masnih kiselina." Master's thesis, University of Zagreb, School of Medicine, 2021. https://urn.nsk.hr/urn:nbn:hr:105:520472

Mihaljević, I. (2021). 'Povezanost psihijatrijskih poremećaja i metabolizma nezasićenih masnih kiselina', Master's thesis, University of Zagreb, School of Medicine, accessed 08 January 2025, https://urn.nsk.hr/urn:nbn:hr:105:520472

Mihaljević I. Povezanost psihijatrijskih poremećaja i metabolizma nezasićenih masnih kiselina [Master's thesis]. Zagreb: University of Zagreb, School of Medicine; 2021 [cited 2025 January 08] Available at: https://urn.nsk.hr/urn:nbn:hr:105:520472

I. Mihaljević, "Povezanost psihijatrijskih poremećaja i metabolizma nezasićenih masnih kiselina", Master's thesis, University of Zagreb, School of Medicine, Zagreb, 2021. Available at: https://urn.nsk.hr/urn:nbn:hr:105:520472

Metadata
TitlePovezanost psihijatrijskih poremećaja i metabolizma nezasićenih masnih kiselina
Title (english)The association of psychiatric disorders and metabolism of unsaturated fatty acids
AuthorIvana Mihaljević
MentorIvančica Delaš (mentor)
Committee memberSlavica Potočki (predsjednik povjerenstva)
Committee memberDragana Fabris (član povjerenstva)
Committee memberIvančica Delaš (član povjerenstva)
GranterUniversity of Zagreb
School of Medicine
(Department of Medical Chemistry, Biochemistry and Clinical Chemistry)
Zagreb
Defense date and country2021-09-11, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Medical Biochemistry
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Clinical Biochemistry
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Psychiatry
Abstract
Tijekom prošlog stoljeća dramatično se u ljudskoj prehrani smanjio unos n-3 višestruko nezasićenih masnih kiselina (engl. PUFA), a istovremeno se povećala incidencija različitih psihijatrijskih poremećaja. Procjenjuje se da u suvremenoj prehrani omjer n-6:n-3 PUFA iznosi 20:1. To pokazuje da suvremena prehrana nije zadovoljavajuća zbog toga što bi omjer n-6:n-3 PUFA u prehrani trebao biti 4:1 kako bi se postigli svi pozitivni učinci za očuvanje zdravlja. Još se 80-ih godina prošlog stoljeća javila ideja da psihijatrijski poremećaji mogu biti posljedica nedostatka n-3 višestruko nezasićenih masnih kiselina. Zbog povećanja učestalosti psihijatrijskih poremećaja i ograničene učinkovitosti dostupnih lijekova, kao i čestih neželjenih nuspojava, postoji potreba za novim metodama liječenja. Posljednjih godina povećan je interes za istraživanje povezanosti psihijatrijskih poremećaja i višestruko nezasićenih masnih kiselina. Otkrivene su različite promjene statusa n-6 i n-3 PUFA u različitim psihijatrijskim poremećajima te predloženi brojni mehanizmi kojima bi ove kiseline mogle utjecati na pojavu psihijatrijskih poremećaja. Mnogo je istraživanja pokazalo pozitivan učinak suplementacije n-3 višestruko nezasićenih masnih kiselina na prevenciju psihijatrijskih bolesti i njihove simptome. Međutim, rezultati tih istraživanja nisu konkluzivni pa je potrebno provesti daljnja istraživanja kako bi se utvrdili točni mehanizmi povezanosti psihijatrijskih poremećaja i metabolizma nezasićenih masnih kiselina te predložili protokoli liječenja primjenom n-3 PUFA kojima bi se poboljšala klinička slika te potencijalno prevenirali mnogi psihijatrijski poremećaji.
Abstract (english)
Over the past century, the intake of n-3 polyunsaturated fatty acids (PUFA) in the human diet has dramatically decreased and at the same time the incidence of various psychiatric disorders has increased. It is estimated that the n-6:n-3 ratio of polyunsaturated fatty acids in modern diet is 20:1. This shows that modern diet is not adequate because the n-6:n-3 PUFA ratio in the diet should be 4:1 to achieve all positive health effects. In the 1980s, the idea emerged that psychiatric disorders could be the result of a deficiency of n-3 polyunsaturated fatty acids. Due to the increased incidence of psychiatric disorders and the limited effectiveness of available medications, as well as frequent side effects, there exists a need for new treatments. In recent years, there has been a growing interest in researching the association between psychiatric disorders and polyunsaturated fatty acids. Various changes in the n-6 and n-3 PUFA status in various psychiatric disorders have been discovered, and a number of mechanisms have been proposed by which these acids could influence the appearance of psychiatric disorders. Many studies have shown a positive effect of n-3 polyunsaturated fatty acid supplementation on the prevention of psychiatric illnesses and their symptoms. However, the results of these studies are not conclusive, so further research is needed to determine the exact mechanisms of association between psychiatric disorders and unsaturated fatty acid metabolism and to propose treatment protocols for n-3 polyunsaturated fatty acids that could improve clinical picture and potentially prevent many psychiatric disorders.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:105:520472
Study programmeTitle: Medicine
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2022-03-11 11:59:06