prikaz prve stranice dokumenta Association of pre-existing comorbidities with outcome of allogeneic hematopoietic cell transplantation. A retrospective analysis from the EBMT
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Scientific paper - Original scientific paper
Association of pre-existing comorbidities with outcome of allogeneic hematopoietic cell transplantation. A retrospective analysis from the EBMT
Bone Marrow Transplantation, 57 (2022), 2; 183-190. https://doi.org/10.1038/s41409-021-01502-8
Penack, Olaf; Peczynski, Christophe; Mohty, Mohamad; Yakoub-Agha, Ibrahim; de la Camara, Rafael; Glass, Bertram; Duarte, Rafael F.; Kröger, Nicolaus; Schoemans, Hélène; Koenecke, Christian; Perić, Zinaida; Basak, Grzegorz W.

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Penack, O., Peczynski, C., Mohty, M., Yakoub Agha, I., de la Camara, R., Glass, B. ... Basak, G. W. (2022). Association of pre-existing comorbidities with outcome of allogeneic hematopoietic cell transplantation. A retrospective analysis from the EBMT. Bone Marrow Transplantation, 57. (2), 183-190. doi: 10.1038/s41409-021-01502-8

Penack, Olaf, et al. "Association of pre-existing comorbidities with outcome of allogeneic hematopoietic cell transplantation. A retrospective analysis from the EBMT." Bone Marrow Transplantation, vol. 57, no. 2, 2022, pp. 183-190. https://doi.org/10.1038/s41409-021-01502-8

Penack, Olaf, Christophe Peczynski, Mohamad Mohty, Ibrahim Yakoub Agha, Rafael de la Camara, Bertram Glass, Rafael F. Duarte, et al. "Association of pre-existing comorbidities with outcome of allogeneic hematopoietic cell transplantation. A retrospective analysis from the EBMT." Bone Marrow Transplantation 57, no. 2 (2022): 183-190. https://doi.org/10.1038/s41409-021-01502-8

Penack, O., et al. (2022) 'Association of pre-existing comorbidities with outcome of allogeneic hematopoietic cell transplantation. A retrospective analysis from the EBMT', Bone Marrow Transplantation, 57(2), pp. 183-190. doi: 10.1038/s41409-021-01502-8

Penack O, Peczynski C, Mohty M, Yakoub Agha I, de la Camara R, Glass B, and sur.. Association of pre-existing comorbidities with outcome of allogeneic hematopoietic cell transplantation. A retrospective analysis from the EBMT. Bone Marrow Transplantation [Internet]. 2022 February [cited 2025 January 21];57(2):183-190. doi: 10.1038/s41409-021-01502-8

O. Penack, et al., "Association of pre-existing comorbidities with outcome of allogeneic hematopoietic cell transplantation. A retrospective analysis from the EBMT", Bone Marrow Transplantation, vol. 57, no. 2, pp. 183-190, February 2022. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:255189. [Accessed: 21 January 2025]

Metadata
Title (english)Association of pre-existing comorbidities with outcome of allogeneic hematopoietic cell transplantation. A retrospective analysis from the EBMT
AuthorOlaf Penack
AuthorChristophe Peczynski
AuthorMohamad Mohty
AuthorIbrahim Yakoub-Agha
AuthorRafael de la Camara
AuthorBertram Glass
AuthorRafael F. Duarte
AuthorNicolaus Kröger
AuthorHélène Schoemans
AuthorChristian Koenecke
AuthorZinaida Perić
AuthorGrzegorz W. Basak
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (english)
Risk assessment of allogeneic hematopoietic cell transplantation (allo-HCT) is hindered by the lack of current data on comorbidities and outcome. The EBMT identified 38,760 allo-HCT recipients with hematologic malignancies transplanted between 2010 and 2018 from matched sibling and unrelated donors with a full data set of pre-existing comorbidities. Multivariate analyses using the Cox proportional-hazards model including known risk factors for non-relapse mortality (NRM) were performed. We found that pre-existing renal comorbidity had the strongest association with NRM (hazard ratio [HR] 1.85 [95% CI 1.55–2.19]). In addition, the association of multiple pre-existing comorbidities with NRM was significant, including diabetes, infections, cardiac comorbidity, and pulmonary comorbidity. However, the HR of the association of these comorbidities with NRM was relatively low and did not exceed 1.24. Consequently, the risk of NRM was only moderately increased in patients with a high hematopoietic cell transplantation comorbidity index (HCT-CI) ≥ 3 (HR 1.34 [1.26–1.42]). In the current EBMT population, pre-existing non-renal comorbidities determined NRM after allo-HCT to a much lesser extent as compared with the underlying HCT-CI data. Improvements in management and supportive care as well as higher awareness based on the use of HCT-CI may have contributed to this favorable development.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleBone Marrow Transplantation
Numberingvol. 57, no. 2, pp. 183-190
p-ISSN0268-3369
e-ISSN1476-5365
DOIhttps://doi.org/10.1038/s41409-021-01502-8
URN:NBNurn:nbn:hr:105:255189
Publication2022-02
Document URLhttps://www.nature.com/articles/s41409-021-01502-8
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2022-03-15 09:20:18