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master's thesis
Učestalost pojave oštećenja jetre s pruritusom kod trudnica zaprimljenih u KB Sveti Duh u periodu 2016.-2020.
Zagreb: University of Zagreb, School of Medicine, 2021. urn:nbn:hr:105:990459
Pavelić, Ena
University of Zagreb
School of Medicine
Department of Gynecology and Obstetrics

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Pavelić, E. (2021). Učestalost pojave oštećenja jetre s pruritusom kod trudnica zaprimljenih u KB Sveti Duh u periodu 2016.-2020. (Master's thesis). Zagreb: University of Zagreb, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:990459

Pavelić, Ena. "Učestalost pojave oštećenja jetre s pruritusom kod trudnica zaprimljenih u KB Sveti Duh u periodu 2016.-2020.." Master's thesis, University of Zagreb, School of Medicine, 2021. https://urn.nsk.hr/urn:nbn:hr:105:990459

Pavelić, Ena. "Učestalost pojave oštećenja jetre s pruritusom kod trudnica zaprimljenih u KB Sveti Duh u periodu 2016.-2020.." Master's thesis, University of Zagreb, School of Medicine, 2021. https://urn.nsk.hr/urn:nbn:hr:105:990459

Pavelić, E. (2021). 'Učestalost pojave oštećenja jetre s pruritusom kod trudnica zaprimljenih u KB Sveti Duh u periodu 2016.-2020.', Master's thesis, University of Zagreb, School of Medicine, accessed 24 December 2024, https://urn.nsk.hr/urn:nbn:hr:105:990459

Pavelić E. Učestalost pojave oštećenja jetre s pruritusom kod trudnica zaprimljenih u KB Sveti Duh u periodu 2016.-2020. [Master's thesis]. Zagreb: University of Zagreb, School of Medicine; 2021 [cited 2024 December 24] Available at: https://urn.nsk.hr/urn:nbn:hr:105:990459

E. Pavelić, "Učestalost pojave oštećenja jetre s pruritusom kod trudnica zaprimljenih u KB Sveti Duh u periodu 2016.-2020.", Master's thesis, University of Zagreb, School of Medicine, Zagreb, 2021. Available at: https://urn.nsk.hr/urn:nbn:hr:105:990459

Metadata
TitleUčestalost pojave oštećenja jetre s pruritusom kod trudnica zaprimljenih u KB Sveti Duh u periodu 2016.-2020.
Title (english)Frequency of liver damage with pruritus in pregnant women admitted at the University Hospital "Sveti Duh" in the period 2016-2020
AuthorEna Pavelić
MentorVladimir Blagaić (mentor)
Committee memberOliver Vasilj (predsjednik povjerenstva)
Committee memberDinka Pavičić Baldani (član povjerenstva)
Committee memberVladimir Blagaić (član povjerenstva)
GranterUniversity of Zagreb
School of Medicine
(Department of Gynecology and Obstetrics)
Zagreb
Defense date and country2021-07-16, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Gynecology and Obstetrics
Abstract
Oštećenja jetre popraćena pruritusom vrlo su česta u trudnoći. Naime procjenjuje se da pruritus zahvaća gotovo 20% trudnica (1). Tijekom trudnoće dolazi do niza fizioloških promjena u cijelom tijelu žene pa tako i u jetri. Osim što povećanje maternice dovodi do progresivnog pomaka ošita kranijalno (maksimalno čak do 4 cm) pa samim time i jetre, biokemijski parametri jetrene funkcije mogu biti promijenjeni. Tako dolazi do vrlo zamjetnog povišenja koncentracije ukupnog kolesterola i triglicerida, serumske koncentracije ALP-a, koja se povećava čak 2-4 puta u odnosu na normalu (pogotovo zbog sinteze ALP u posteljici). Serumska koncentracija GGT-a može biti znatno smanjena, a koncentracija 5'-nukleozidaze blago povišena. Međutim, uočljivo povišenje serumske koncentracije aminotransferaza, bilirubina ili ukupnih žučnih kiselina tijekom trudnoće može ukazivati na ozbiljnu patologiju jetre te na nužnost daljnje kliničke obrade (2). Pretpostavlja se da povećane koncentracije spolnih hormona tijekom trudnoće (estrogena i progesterona), pogotovo u 2. i 3. tromjesečju, pridonose metaboličkoj opterećenosti jetre, što potom rezultira povišenim serumskim pokazateljima kao što su ALT, AST, GGT, ALP i žučne kiseline, što također ide u prilog činjenici da se neki od navedenih jetrenih poremećaja i javljaju uglavnom krajem 2. i tijekom 3. tromjesečja.
Abstract (english)
Liver damage accompanied by pruritus is very common in pregnancy. Namely, it is estimated that pruritus affects almost 20% of pregnant women (1). During pregnancy, numerous physiological changes occur in a woman's entire body, including the liver. In addition to the fact that the enlargement of the uterus leads to a progressive shift to the cranial direction (up to a maximum of 4 cm) and thus the liver, the biochemical parameters of liver function can be changed. Thus, there is a very noticeable increase in the concentration of total cholesterol and triglycerides, the serum concentration of ALP, which increases as much as 2-4 times compared to normal (especially due to the synthesis of ALP in the placenta). Serum GGT levels may be significantly reduced and 5'-nucleosidase levels may be slightly elevated. However, a marked increase in serum aminotransferases, bilirubin or total bile acids during pregnancy may indicate serious liver pathology and the need for further clinical treatment (2). Increased concentrations of sex hormones during pregnancy (estrogen and progesterone), especially in the 2nd and 3rd trimesters, are thought to contribute to the metabolic load of the liver, which then results in elevated serum levels such as ALT, AST, GGT, ALP and bile acids, which also supports the fact that some of these liver disorders also occur mainly in the late 2nd and during the 3rd trimester.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:105:990459
Study programmeTitle: Medicine
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2022-03-24 12:39:23