Because of the severity of the growing problem of infertility, scientific communities around the world are putting in effort to solve this problem. So far the biggest revolution in the area have been new assisted reproductive technologies, which give infertile couples hope and, often, solutions. Nonetheless, because of the limitations of ART, there is a demand to increase success rate, and to increase fertility in general. One of the possible approaches to increasing success of infertility treatment is the use of nutrients and food supplements. In this paper literature search was conducted to review publications from several data bases to summarize evidence of effectiveness and safety of nutritients and food supplements on the outcome of infertility treatment. Nutrients and food supplements that are reviewed in this paper are antioxidants (carnitine, vitamin E, vitamin C, pentoxifylline, carotenoids,melatonin), vitamins (folic acid, vitamin B6, vitamin B12, inositol, vitamin D), L-arginine, omega 3 fatty acids, metals and trace elements (zinc and selenium) and mixed supplements and multivitamins. There is evidence of effectiveness of each supplement, but it is not always clear and uniform. The main shortcoming of the papers reviewed, is low power and heterogeneity, which makes it difficult to reach a clear and uniform conclusion. Further research is needed, if possible on single supplement and uniform patient group in order to form future clinical practice recommendations.