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master's thesis
Epidemiološka i klinička očitovanja pandemije i infekcije COVID -19 na program i ishode transplantacije jetre
Zagreb: University of Zagreb, School of Medicine, 2021. urn:nbn:hr:105:036014
Perica, Maja
University of Zagreb
School of Medicine
Department of Internal Medicine

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Perica, M. (2021). Epidemiološka i klinička očitovanja pandemije i infekcije COVID -19 na program i ishode transplantacije jetre (Master's thesis). Zagreb: University of Zagreb, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:036014

Perica, Maja. "Epidemiološka i klinička očitovanja pandemije i infekcije COVID -19 na program i ishode transplantacije jetre." Master's thesis, University of Zagreb, School of Medicine, 2021. https://urn.nsk.hr/urn:nbn:hr:105:036014

Perica, Maja. "Epidemiološka i klinička očitovanja pandemije i infekcije COVID -19 na program i ishode transplantacije jetre." Master's thesis, University of Zagreb, School of Medicine, 2021. https://urn.nsk.hr/urn:nbn:hr:105:036014

Perica, M. (2021). 'Epidemiološka i klinička očitovanja pandemije i infekcije COVID -19 na program i ishode transplantacije jetre', Master's thesis, University of Zagreb, School of Medicine, accessed 23 November 2024, https://urn.nsk.hr/urn:nbn:hr:105:036014

Perica M. Epidemiološka i klinička očitovanja pandemije i infekcije COVID -19 na program i ishode transplantacije jetre [Master's thesis]. Zagreb: University of Zagreb, School of Medicine; 2021 [cited 2024 November 23] Available at: https://urn.nsk.hr/urn:nbn:hr:105:036014

M. Perica, "Epidemiološka i klinička očitovanja pandemije i infekcije COVID -19 na program i ishode transplantacije jetre", Master's thesis, University of Zagreb, School of Medicine, Zagreb, 2021. Available at: https://urn.nsk.hr/urn:nbn:hr:105:036014

Metadata
TitleEpidemiološka i klinička očitovanja pandemije i infekcije COVID -19 na program i ishode transplantacije jetre
Title (english)Epidemiological and clinical manifestations of COVID-19 pandemic and infection on liver transplant program and outcomes
AuthorMaja Perica
MentorAnna Mrzljak (mentor)
Committee memberTatjana Vilibić Čavlek (predsjednik povjerenstva)
Committee memberJasenka Markeljević (član povjerenstva)
Committee memberAnna Mrzljak (član povjerenstva)
GranterUniversity of Zagreb
School of Medicine
(Department of Internal Medicine)
Zagreb
Defense date and country2021-07-16, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract
COVID-19, bolest koju uzrokuje SARS-CoV-2 pojavila se prvi puta u prosincu 2019. godine u kineskom gradu Wuhanu, brzo se proširila cijelim svijetom te je 11. ožujka 2020. godine Svjetska zdravstvena organizacija proglasila pandemiju. Iako je COVID-19 primarno respiratorna bolest, ona može zahvaćati i druge organe, poput jetre. Oštećenje jetre najčešće se manifestira asimptomatskim porastom transaminaza, no u pacijenta s kroničnim jetrenim bolestima može doći do pogoršanja i dekompenzacije bolesti te potrebe za transplantacijom. Osobe s kroničnim jetrenim bolestima i osobe s jetrenim presatkom pod povećanim su rizikom za razvoj teške kliničke slike COVID-19. Imunosupresivna terapija u transplantiranih pacijenata može biti razlog povećanog rizika za razvoj teške kliničke slike bolesti COVID-19, no može imati i protektivni učinak, ovisno o vrsti imunosupresivne terapije. U transplantiranih pacijenata oboljelih od COVID-19 česte su interakcije imunosupresivnih lijekova s lijekovima za terapiju COVID-19, te je stoga potrebno prilagoditi vrstu i dozu imunosupresivne terapije. Pandemija COVID-19 imala je značajan učinak na program transplantacije jetre, koji je bio vidljiv iz smanjenog broja pacijenata uvrštenih na transplantacijsku listu, smanjenog broja dostupnih donora te konačno, smanjenog broja provedenih transplantacija. U područjima u kojima je na početku pandemije incidencija COVID-19 bila veća, transplantacijski program bio je značajnije pogođen nego u područjima u kojima se incidencija COVID-19 povećala nešto kasnije. Učinak pandemije najviše se osjetio u ožujku i travnju 2020. godine, no transplantacijski program se ubrzo nakon toga počeo oporavljati, što govori u prilog dobroj prilagodbi transplantacijskog sustava na uvjete pandemije. Danas već postoje i primjeri uspješno provedenih transplantacija u pacijenata oboljelih od COVID-19.
Abstract (english)
COVID-19, a disease caused by the SARS-CoV-2, first appeared in December 2019 in the Chinese city of Wuhan, spread rapidly around the world, and the World Health Organization declared a pandemic on March 11th 2020. Although COVID-19 is primarily a respiratory disease, it can also affect other organs, such as the liver. While the liver injury is mostly manifested by an asymptomatic transaminitis, in patients with chronic liver disease it can also cause exacerbation and decompensation of the disease which may result in the need for liver transplantation. Patients with chronic liver disease and patients with a liver transplant are at increased risk of developing severe COVID-19. Immunosuppressive therapy in transplant patients may increase the risk of developing severe COVID-19, but may also have a protective effect, depending on the type of immunosuppressive therapy. Interactions of immunosuppressive drugs with drugs used in COVID-19 are common in transplant patients with COVID-19 and therefore, the type and dose of immunosuppressive drugs should be adjusted. The COVID-19 pandemic had a significant impact on the liver transplant program, which was evident from the reduced number of patients included in the transplant list, the reduced number of available donors, and finally, the reduced number of transplants performed. In areas where the incidence of COVID-19 was higher at the beginning of the pandemic, the transplant program was more significantly affected than in areas where the incidence of COVID-19 increased somewhat later. The impact of the pandemic was most obvious in March and April 2020, after which the program began to recover, which shows successful adaptation of the transplant system to pandemic conditions. Today, there are already examples of successfully performed transplants in patients with COVID-19.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:105:036014
Study programmeTitle: Medicine
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2022-03-24 13:32:21