prikaz prve stranice dokumenta Zoledronate Bound to Ceramics Increases Ectopic Bone Volume Induced by rhBMP6 Delivered in Autologous Blood Coagulum in Rats
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Scientific paper - Original scientific paper
Zoledronate Bound to Ceramics Increases Ectopic Bone Volume Induced by rhBMP6 Delivered in Autologous Blood Coagulum in Rats
Biomedicines, 9 (2021), 10; 1487. https://doi.org/10.3390/biomedicines9101487
Štoković, Nikola; Ivanjko, Natalia; Erjavec, Igor; Breski, Anita; Perć, Mihaela; Vukičević, Slobodan

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Štoković, N., Ivanjko, N., Erjavec, I., Breski, A., Perć, M. & Vukičević, S. (2021). Zoledronate Bound to Ceramics Increases Ectopic Bone Volume Induced by rhBMP6 Delivered in Autologous Blood Coagulum in Rats. Biomedicines, 9. (10). doi: 10.3390/biomedicines9101487

Štoković, Nikola, et al. "Zoledronate Bound to Ceramics Increases Ectopic Bone Volume Induced by rhBMP6 Delivered in Autologous Blood Coagulum in Rats." Biomedicines, vol. 9, no. 10, 2021. https://doi.org/10.3390/biomedicines9101487

Štoković, Nikola, Natalia Ivanjko, Igor Erjavec, Anita Breski, Mihaela Perć and Slobodan Vukičević. "Zoledronate Bound to Ceramics Increases Ectopic Bone Volume Induced by rhBMP6 Delivered in Autologous Blood Coagulum in Rats." Biomedicines 9, no. 10 (2021). https://doi.org/10.3390/biomedicines9101487

Štoković, N., et al. (2021) 'Zoledronate Bound to Ceramics Increases Ectopic Bone Volume Induced by rhBMP6 Delivered in Autologous Blood Coagulum in Rats', Biomedicines, 9(10). doi: 10.3390/biomedicines9101487

Štoković N, Ivanjko N, Erjavec I, Breski A, Perć M, Vukičević S. Zoledronate Bound to Ceramics Increases Ectopic Bone Volume Induced by rhBMP6 Delivered in Autologous Blood Coagulum in Rats. Biomedicines [Internet]. 2021 October 16 [cited 2024 August 10];9(10). doi: 10.3390/biomedicines9101487

N. Štoković, N. Ivanjko, I. Erjavec, A. Breski, M. Perć and S. Vukičević, "Zoledronate Bound to Ceramics Increases Ectopic Bone Volume Induced by rhBMP6 Delivered in Autologous Blood Coagulum in Rats", Biomedicines, vol. 9, no. 10, October 2021. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:996950. [Accessed: 10 August 2024]

Metadata
Title (english)Zoledronate Bound to Ceramics Increases Ectopic Bone Volume Induced by rhBMP6 Delivered in Autologous Blood Coagulum in Rats
AuthorNikola Štoković
AuthorNatalia Ivanjko
AuthorIgor Erjavec
AuthorAnita Breski
AuthorMihaela Perć
AuthorSlobodan Vukičević
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Anatomy and Clinical Anatomy)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Anatomy
Abstract (english)
Autologous bone graft substitute (ABGS) containing rhBMP6 in autologous blood coagulum (ABC) with synthetic ceramics is a novel therapeutic solution for bone repair. The aim of this study was to investigate whether the application of Zoledronate (ZOL) with ABGS might enhance the properties of newly formed bone. The effect of ZOL on bone induction was tested in a rat subcutaneous implant model. ZOL bound to synthetic ceramics was added into ABGS implants, and the quantity, quality, and longevity of the induced bone were assessed by micro-CT, histomorphometry, and histology over a period of 365 days. Local use of ZOL in the ABGS implants with ceramics had no influence on the bone volume (BV) on day 14 but subsequently significantly increased BV on days 35, 50, 105, 140, and 365 compared to the control implants. Locally applied ZOL had a similar effect in all of the applied doses (2–20 µg), while its systemic use on stimulating the BV of newly induced bone by ABGS depended on the time of application. BV was increased when ZOL was applied systemically on day 14 but had no effect when applied on day 35. The administration of ZOL bound to ceramics in ABGS increased and maintained the BV over a period of one year, offering a novel bone tissue engineering strategy for treating bone defects and spinal fusions.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleBiomedicines
Numberingvol. 9, no. 10, 1487
e-ISSN2227-9059
DOIhttps://doi.org/10.3390/biomedicines9101487
URN:NBNurn:nbn:hr:105:996950
Publication2021-10-16
ProjectNumber: KK.01.1.1.01.0008
Title (croatian): Znanstveni centar izvrsnosti za reproduktivnu i regenerativnu medicinu – istraživanja novih platformi i potencijala
Title (english): Reproductive, and Regenerative Medicine-Exploring New Platforms and Potentials
Acronym: CERRM
Leader: Slobodan Vukičević
Jurisdiction: eu
Document URLhttps://www.mdpi.com/2227-9059/9/10/1487
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2022-04-01 11:12:59