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Scientific paper - Original scientific paper
Constitutive Serotonin Tone Modulates Molecular and Behavioral Response to Chronic Fluoxetine Treatment: A Study on Genetic Rat Model
Frontiers in Psychiatry, 12 (2021); 741222. https://doi.org/10.3389/fpsyt.2021.741222
Kesić, Maja; Mokrović, Gordana; Tvrdeić, Ante; Miše, Branko; Štefulj, Jasminka; Čičin-Šain, Lipa

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Kesić, M., Mokrović, G., Tvrdeić, A., Miše, B., Štefulj, J. & Čičin Šain, L. (2021). Constitutive Serotonin Tone Modulates Molecular and Behavioral Response to Chronic Fluoxetine Treatment: A Study on Genetic Rat Model. Frontiers in Psychiatry, 12.. doi: 10.3389/fpsyt.2021.741222

Kesić, Maja, et al. "Constitutive Serotonin Tone Modulates Molecular and Behavioral Response to Chronic Fluoxetine Treatment: A Study on Genetic Rat Model." Frontiers in Psychiatry, vol. 12, 2021. https://doi.org/10.3389/fpsyt.2021.741222

Kesić, Maja, Gordana Mokrović, Ante Tvrdeić, Branko Miše, Jasminka Štefulj and Lipa Čičin Šain. "Constitutive Serotonin Tone Modulates Molecular and Behavioral Response to Chronic Fluoxetine Treatment: A Study on Genetic Rat Model." Frontiers in Psychiatry 12 (2021). https://doi.org/10.3389/fpsyt.2021.741222

Kesić, M., et al. (2021) 'Constitutive Serotonin Tone Modulates Molecular and Behavioral Response to Chronic Fluoxetine Treatment: A Study on Genetic Rat Model', Frontiers in Psychiatry, 12. doi: 10.3389/fpsyt.2021.741222

Kesić M, Mokrović G, Tvrdeić A, Miše B, Štefulj J, Čičin Šain L. Constitutive Serotonin Tone Modulates Molecular and Behavioral Response to Chronic Fluoxetine Treatment: A Study on Genetic Rat Model. Frontiers in Psychiatry [Internet]. 2021 October [cited 2024 November 25];12. doi: 10.3389/fpsyt.2021.741222

M. Kesić, G. Mokrović, A. Tvrdeić, B. Miše, J. Štefulj and L. Čičin Šain, "Constitutive Serotonin Tone Modulates Molecular and Behavioral Response to Chronic Fluoxetine Treatment: A Study on Genetic Rat Model", Frontiers in Psychiatry, vol. 12, October 2021. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:010544. [Accessed: 25 November 2024]

Metadata
Title (english)Constitutive Serotonin Tone Modulates Molecular and Behavioral Response to Chronic Fluoxetine Treatment: A Study on Genetic Rat Model
AuthorMaja Kesić
AuthorGordana Mokrović
AuthorAnte Tvrdeić
AuthorBranko Miše
AuthorJasminka Štefulj
AuthorLipa Čičin-Šain
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Pharmacology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Pharmacology
Abstract (english)
Selective serotonin reuptake inhibitors (SSRIs) are the most commonly prescribed medications for the treatment of mood disorders. Yet, individual response to SSRIs is highly variable, with only a portion of patients showing the desired therapeutic effect. To better understand the molecular basis underlying individual variability in response to SSRIs, here we comparatively studied behavioral and molecular consequences of chronic treatment with fluoxetine, a widely used SSRI, in two sublines of rats with constitutionally different serotonin (5HT) homeostasis: the high-5HT and low-5HT sublines. Platelet 5HT levels, a recognized indicator of SSRI efficacy, were decreased by fluoxetine treatment in both 5HT-sublines. On the other hand, biologically active plasma 5HT levels were reduced only in high-5HT rats. The anxiolytic effect of fluoxetine was also evident only in high-5HT rats, as supported by spatio-temporal and ethological behavioral measures in the elevated plus maze (EPM) test and exploratory behavior measures in the open field (OF) test. None of the behavioral EPM or OF measures were significantly altered by fluoxetine treatment in low-5HT rats. Unexpectedly, 5HT levels in cerebral cortices tended to be reduced only in low-5HT rats. Moreover, the effects of fluoxetine on cortical expression levels of 5HT-related proteins were also present only in low-5HT rats, with serotonin transporter (5HTT) and serotonin receptor type 1a (Htr1a) being down-regulated, while serotonin receptor type 4 (Htr4) was up-regulated by fluoxetine treatment. The obtained results support a role of individual 5HT tone as an important influencing factor on the biological actions of SSRI antidepressants.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleFrontiers in Psychiatry
Numberingvol. 12, 741222
e-ISSN1664-0640
DOIhttps://doi.org/10.3389/fpsyt.2021.741222
URN:NBNurn:nbn:hr:105:010544
Publication2021-10
Document URLhttps://www.frontiersin.org/articles/10.3389/fpsyt.2021.741222/full
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2022-04-07 07:53:03