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Scientific paper - Original scientific paper
FibroScan-AST Score Predicts 30-Day Mortality or Need for Mechanical Ventilation among Patients Hospitalized with COVID-19
Journal of Clinical Medicine, 10 (2021), 19; 4355. https://doi.org/10.3390/jcm10194355
Zelenika, Marko; Lucijanić, Marko; Bokun, Tomislav; Božin, Tonči; Barišić Jaman, Mislav; Tješić Drinković, Ida; Paštrović, Frane; Madir, Anita; Lukšić, Ivica; Piskač Živković, Nevenka; Luetić, Krešimir; Krznarić, Željko; Ostojić, Rajko; Filipec Kanižaj, Tajana; Bogadi, Ivan; Virović Jukić, Lucija; Kukla, Michal; Grgurević, Ivica More authors...

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Zelenika, M., Lucijanić, M., Bokun, T., Božin, T., Barišić Jaman, M., Tješić Drinković, I. ... Grgurević, I. (2021). FibroScan-AST Score Predicts 30-Day Mortality or Need for Mechanical Ventilation among Patients Hospitalized with COVID-19. Journal of Clinical Medicine, 10. (19). doi: 10.3390/jcm10194355

Zelenika, Marko, et al. "FibroScan-AST Score Predicts 30-Day Mortality or Need for Mechanical Ventilation among Patients Hospitalized with COVID-19." Journal of Clinical Medicine, vol. 10, no. 19, 2021. https://doi.org/10.3390/jcm10194355

Zelenika, Marko, Marko Lucijanić, Tomislav Bokun, Tonči Božin, Mislav Barišić Jaman, Ida Tješić Drinković, Frane Paštrović, et al. "FibroScan-AST Score Predicts 30-Day Mortality or Need for Mechanical Ventilation among Patients Hospitalized with COVID-19." Journal of Clinical Medicine 10, no. 19 (2021). https://doi.org/10.3390/jcm10194355

Zelenika, M., et al. (2021) 'FibroScan-AST Score Predicts 30-Day Mortality or Need for Mechanical Ventilation among Patients Hospitalized with COVID-19', Journal of Clinical Medicine, 10(19). doi: 10.3390/jcm10194355

Zelenika M, Lucijanić M, Bokun T, Božin T, Barišić Jaman M, Tješić Drinković I, and sur.. FibroScan-AST Score Predicts 30-Day Mortality or Need for Mechanical Ventilation among Patients Hospitalized with COVID-19. Journal of Clinical Medicine [Internet]. 2021 September 24 [cited 2024 November 23];10(19). doi: 10.3390/jcm10194355

M. Zelenika, et al., "FibroScan-AST Score Predicts 30-Day Mortality or Need for Mechanical Ventilation among Patients Hospitalized with COVID-19", Journal of Clinical Medicine, vol. 10, no. 19, September 2021. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:787917. [Accessed: 23 November 2024]

Metadata
Title (english)FibroScan-AST Score Predicts 30-Day Mortality or Need for Mechanical Ventilation among Patients Hospitalized with COVID-19
AuthorMarko Zelenika
AuthorMarko Lucijanić
AuthorTomislav Bokun
AuthorTonči Božin
AuthorMislav Barišić Jaman
AuthorIda Tješić Drinković
AuthorFrane Paštrović
AuthorAnita Madir
AuthorIvica Lukšić
AuthorNevenka Piskač Živković
AuthorKrešimir Luetić
AuthorŽeljko Krznarić
MBZ: 75865
AuthorRajko Ostojić
AuthorTajana Filipec Kanižaj
AuthorIvan Bogadi
AuthorLucija Virović Jukić
AuthorMichal Kukla
AuthorIvica Grgurević
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Internal Medicine)
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Maxillofacial Surgery and Dentistry)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Surgery
Abstract (english)
Background: Liver involvement in Coronavirus disease 2019 (COVID-19) has been recognised. We aimed to investigate the correlation of non-invasive surrogates of liver steatosis, fibrosis and inflammation using transient elastography (TE) and FibroScan-AST (FAST) score with (a) clinical severity and (b) 30-day composite outcome of mechanical ventilation (MV) or death among patients hospitalized due to COVID-19. ----- Method: Patients with non-critical COVID-19 at admission were included. Liver stiffness measurement (LSM) and controlled attenuation parameter (CAP) were assessed by TE. Clinical severity of COVID-19 was assessed by 4C Mortality Score (4CMS) and need for high-flow nasal cannula (HFNC) oxygen supplementation. -----nResults: 217 patients were included (66.5% males, median age 65 years, 4.6% with history of chronic liver disease). Twenty-four (11.1%) patients met the 30-day composite outcome. Median LSM, CAP and FAST score were 5.2 kPa, 274 dB/m and 0.31, respectively, and neither was associated with clinical severity of COVID-19 at admission. In multivariate analysis FAST > 0.36 (OR 3.19, p = 0.036), 4CMS (OR 1.68, p = 0.002) and HFNC (OR 7.03, p = 0.001) were independent predictors of adverse composite outcome. ----- Conclusion: Whereas LSM and CAP failed to show correlation with COVID-19 severity and outcomes, FAST score was an independent risk factor for 30-day mortality or need for MV.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleJournal of Clinical Medicine
Numberingvol. 10, no. 19, 4355
e-ISSN2077-0383
DOIhttps://doi.org/10.3390/jcm10194355
URN:NBNurn:nbn:hr:105:787917
Publication2021-09-24
Document URLhttps://www.mdpi.com/2077-0383/10/19/4355
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2022-04-07 09:47:42