prikaz prve stranice dokumenta CSF tau proteins in evaluation of patients with suspected dementia
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Scientific paper - Original scientific paper
CSF tau proteins in evaluation of patients with suspected dementia
In: New Trends in Alzheimer and Parkinson related disorders: ADPD 2007.. Bologna Medimond, 2008. pp. 239-243. urn:nbn:hr:105:399216
Šimić, Goran; Boban, Marko; Šarac, Helena; Grbić, Kristina; Hof, Patrick R.; Hamann, C.; Ackl, Nibal; Bader, Benedikt; Danek, Adrian

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Šimić, G., Boban, M., Šarac, H., Grbić, K., Hof, P. R., Hamann, C. ... Danek, A. (2008). CSF tau proteins in evaluation of patients with suspected dementia. New Trends in Alzheimer and Parkinson related disorders: ADPD 2007. (pp. 239-243). Bologna Medimond. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:399216

Šimić, Goran, et al. "CSF tau proteins in evaluation of patients with suspected dementia." New Trends in Alzheimer and Parkinson related disorders: ADPD 2007., Bologna Medimond, 2008, pp. 239-243. https://urn.nsk.hr/urn:nbn:hr:105:399216

Šimić, Goran, Marko Boban, Helena Šarac, Kristina Grbić, Patrick R. Hof, C. Hamann, Nibal Ackl, Benedikt Bader and Adrian Danek. "CSF tau proteins in evaluation of patients with suspected dementia." In New Trends in Alzheimer and Parkinson related disorders: ADPD 2007., 239-243. Bologna Medimond, 2008. Accessed 2024 November 30. https://urn.nsk.hr/urn:nbn:hr:105:399216

Šimić, G., et al. (2008) 'CSF tau proteins in evaluation of patients with suspected dementia', New Trends in Alzheimer and Parkinson related disorders: ADPD 2007., Bologna Medimond, pp. 239-243. Available at: https://urn.nsk.hr/urn:nbn:hr:105:399216 (Accessed 30 November 2024)

Šimić G, Boban M, Šarac H, Grbić K, Hof PR, Hamann C, and sur.. CSF tau proteins in evaluation of patients with suspected dementia. New Trends in Alzheimer and Parkinson related disorders: ADPD 2007.. Bologna Medimond; 2008. Pp. 239-243. [cited 2024 November 30] Available at: https://urn.nsk.hr/urn:nbn:hr:105:399216

G. Šimić, et al., "CSF tau proteins in evaluation of patients with suspected dementia", New Trends in Alzheimer and Parkinson related disorders: ADPD 2007. Bologna Medimond, 2008. [Online] Available at: https://urn.nsk.hr/urn:nbn:hr:105:399216 [Accessed: 30 November 2024]

Metadata
Title (english)CSF tau proteins in evaluation of patients with suspected dementia
AuthorGoran Šimić
AuthorMarko Boban
AuthorHelena Šarac
AuthorKristina Grbić
AuthorPatrick R. Hof
AuthorC. Hamann
AuthorNibal Ackl
AuthorBenedikt Bader
AuthorAdrian Danek
Author's institutionUniversity of Zagreb
School of Medicine
(Croatian Institiute for Brain Research)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Neuroscience
Abstract (english)
Using commercially available ELISA kits, we evaluated the diagnostic value of CSF total tau protein (t-tau), tau phosphorylated at threonine 181 and serine 199 (p-tau181 and p-tau199) in early Alzheimer's disease (AD) versus healthy controls (HC) and other primary causes of dementia, such as frontotemporal dementia (FTD), vascular dementia (VaD) and dementia with Lewy-bodies (DLB). Mean CSF t-tau and CSF p-tau181 levels were significantly elevated in AD patients compared to FTD, VaD and HC. Discrimination between AD and DLB was maximized by using p-tau181 with a sensitivity of 91% and a specificity of 94%, whereas t-tau was optimal to separate AD from VaD with a sensitivity of 91% and specificity of 95%. P-tau199 showed low specificity of 20-30% in distinguishing AD from other groups when sensitivity was set at 85% or greater. We concluded that p-tau181 and t-tau represent useful biological markers for differentiating early AD from other causes of dementia.
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Publication titleNew Trends in Alzheimer and Parkinson related disorders: ADPD 2007.
Numberingpp. 239-243
ISBN9788875874056
URN:NBNurn:nbn:hr:105:399216
Publication2008
ConferenceTitle: The 8th International Conference on Alzheimer’s and Parkinson’s Diseases
Acronym: AD/PD
Location: Salzburg, Austria
Start date: 2007-03-14
End date: 2007-03-18
Assembly type: Lecture
Type of resourceText
PublisherBologna Medimond
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2022-04-11 10:51:08