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Scientific paper - Chapter in Book
Genomic Instability of the APC Gene found in Glioblastoma
In: Genome Research Advances / Bellini, P. Alberto (Ed.). Nova Science Publishers, Inc., 2007. pp. 219-235. urn:nbn:hr:105:120092
Pećina-Šlaus, Nives; Beroš, Vili; Nikuševa-Martić, Tamara; Bulić-Jakuš, Floriana

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Pećina Šlaus, N., Beroš, V., Nikuševa Martić, T. & Bulić Jakuš, F. (2007). Genomic Instability of the APC Gene found in Glioblastoma. In P. A. Bellini, (Ed.), Genome Research Advances (pp. 219-235). Nova Science Publishers, Inc.. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:120092

Pećina Šlaus, Nives, et al. "Genomic Instability of the APC Gene found in Glioblastoma." Genome Research Advances, edited by P. Alberto Bellini, Nova Science Publishers, Inc., 2007, pp. 219-235. https://urn.nsk.hr/urn:nbn:hr:105:120092

Pećina Šlaus, Nives, Vili Beroš, Tamara Nikuševa Martić and Floriana Bulić Jakuš. "Genomic Instability of the APC Gene found in Glioblastoma." In Genome Research Advances, edited by P. Alberto Bellini, 219-235. Nova Science Publishers, Inc., 2007. https://urn.nsk.hr/urn:nbn:hr:105:120092

Pećina Šlaus, N., et al. (2007) 'Genomic Instability of the APC Gene found in Glioblastoma' in Bellini, P. A. (ed.) Genome Research Advances Nova Science Publishers, Inc., pp. 219-235. Available at: https://urn.nsk.hr/urn:nbn:hr:105:120092 (Accessed 06 May 2024)

Pećina Šlaus N, Beroš V, Nikuševa Martić T, Bulić Jakuš F. Genomic Instability of the APC Gene found in Glioblastoma. In: P. A. Bellini, ed. Genome Research Advances. Nova Science Publishers, Inc.; 2007. Pp. 219-235. [cited 2024 May 06] Available at: https://urn.nsk.hr/urn:nbn:hr:105:120092

N. Pećina Šlaus, V. Beroš, T. Nikuševa Martić and F. Bulić Jakuš, "Genomic Instability of the APC Gene found in Glioblastoma", Genome Research Advances, P. A. Bellini, Ed. Nova Science Publishers, Inc., 2007, pp. 219-235. [Online] Available at: https://urn.nsk.hr/urn:nbn:hr:105:120092

Metadata
Title (english)Genomic Instability of the APC Gene found in Glioblastoma
AuthorNives Pećina-Šlaus
AuthorVili Beroš
AuthorTamara Nikuševa-Martić
AuthorFloriana Bulić-Jakuš
EditorP. Alberto Bellini
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Medical Biology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
The etiology and pathogenesis of tumors of the central nervous system are still inadequately explained. This study analyses tumor suppressor gene— adenomatous polyposis coli (APC) in 28 patients with glioblastoma, the most aggressive form of glial tumors. APC protein has a structural role in adherens junctions, but also plays a signaling role as a negative regulator of the wnt pathway. Our interest in the APC gene stemmed principally from the findings that the wild-type APC protein is highly expressed in the central nervous system, and upon the finding that it is critically involved in particular syndromes, among which brain tumors play a significant role. Glioblastoma samples were tested for gene instability by PCR/loss of heterozygosity using RFLP method. Two polymorphic markers were used: an Rsa I polymorphic site in exon 11, and an Msp I polymorphic site in exon 15. The results of our analysis for both markers showed allelic loss of the APC gene in 40% of our sample out of 25 heterozygous patients (informativeness 89%). Another 20% of samples demonstrated allelic imbalance of the APC allele in tumor tissue. Altogether, there were 15 samples (60%) demonstrating instability of this tumor suppressor gene. Despite increasing knowledge on glioma biology and genetics, the prognostic tools for glioblastoma still need improvement. Our findings on genomic instability of the APC gene may contribute to better understanding of glioblastoma genetic profile and could be used as a prognostic marker of disease evolution and progression.
Keywords (english)
Languageenglish
Publication typeScientific paper - Chapter in Book
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Book titleGenome Research Advances
Numberingpp. 219-235
ISBN978-1-60021-805-7
URN:NBNurn:nbn:hr:105:120092
Publication2007
ProjectNumber: 108-1080399-0335
Title (croatian): Eksperimentalni embrionalni tumori i razvoj zametaka sisavaca in vitro i in vivo
Title (english): Experimental embryonic tumors and mammalian development in vitro and in vivo
Leader: Florijana Jakuš
Jurisdiction: Croatia
Funding stream: ZP
ProjectNumber: 108-1081870-1905
Title (croatian): Uloga signalnog puta wnt u tumorigenezi i embriogenezi mozga
Title (english): The role of the wnt signaling pathway in brain tumorigenesis and embriogenesis
Leader: Nives Pećina-Šlaus
Jurisdiction: Croatia
Funding stream: ZP
Type of resourceText
PublisherNova Science Publishers, Inc.
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2022-04-11 11:42:14