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master's thesis
Psorijaza i rizik infarkta srca i mozga
Zagreb: University of Zagreb, School of Medicine, 2021. urn:nbn:hr:105:594984
Radoš, Katarina
University of Zagreb
School of Medicine
Department of Internal Medicine

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

Cite this document

Radoš, K. (2021). Psorijaza i rizik infarkta srca i mozga (Master's thesis). Zagreb: University of Zagreb, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:594984

Radoš, Katarina. "Psorijaza i rizik infarkta srca i mozga." Master's thesis, University of Zagreb, School of Medicine, 2021. https://urn.nsk.hr/urn:nbn:hr:105:594984

Radoš, Katarina. "Psorijaza i rizik infarkta srca i mozga." Master's thesis, University of Zagreb, School of Medicine, 2021. https://urn.nsk.hr/urn:nbn:hr:105:594984

Radoš, K. (2021). 'Psorijaza i rizik infarkta srca i mozga', Master's thesis, University of Zagreb, School of Medicine, accessed 06 May 2024, https://urn.nsk.hr/urn:nbn:hr:105:594984

Radoš K. Psorijaza i rizik infarkta srca i mozga [Master's thesis]. Zagreb: University of Zagreb, School of Medicine; 2021 [cited 2024 May 06] Available at: https://urn.nsk.hr/urn:nbn:hr:105:594984

K. Radoš, "Psorijaza i rizik infarkta srca i mozga", Master's thesis, University of Zagreb, School of Medicine, Zagreb, 2021. Available at: https://urn.nsk.hr/urn:nbn:hr:105:594984

Metadata
TitlePsorijaza i rizik infarkta srca i mozga
Title (english)Myocardial Infarction and stroke risk in patiens with psoriasis
AuthorKatarina Radoš
MentorEdvard Galić (mentor)
Committee memberRomana Čeović (predsjednik povjerenstva)
Committee memberŽeljko Duić (član povjerenstva)
Committee memberEdvard Galić (član povjerenstva)
GranterUniversity of Zagreb
School of Medicine
(Department of Internal Medicine)
Zagreb
Defense date and country2021-07-16, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract
Psorijaza je česta kronična sistemska bolest od koje boluje najmanje 100 milijuna ljudi diljem svijeta. Smatra se da se pojavljuje u genski podložnih pojedinaca u kojih kao okidač djeluju određeni čimbenici iz okoliša. Patofiziologija je kompleksna i uključuje složenu interakciju urođenog i stečenog imunosnog sustava. Klinička slika obilježena je pojavom eritematoznih žarišta prekrivenih ljuskama na predilekcijskim mjestima kao što su ekstenzorne strane udova. Uz psorijazu se javljaju značajni komorbiditeti koji mogu imati velik utjecaj na kvalitetu života te čak i skratiti životni vijek, a uključuju psorijatični artritis, depresiju, metabolički sindrom i kardiovaskularne bolesti. Posljednjih desetljeća intenzivno se istražuje povezanost infarkta srca i mozga sa psorijazom. Povećana incidencija velikih kardiovaskularnih i cerebrovaskularnih događaja, koji uključuju infarkt miokarda i moždani udar, kod bolesnika sa psorijazom može se objasniti pomoću više mehanizama. Bolesnici sa psorijazom često imaju veću prevalenciju klasičnih čimbenika rizika za ova životno ugrožavajuća stanja u odnosu na opću populaciju, uključujući povećanu tjelesnu masu i pretilost, šećernu bolest, hiperlipidemiju i hipertenziju. Također, patofiziologija psorijaze obuhvaća aktiviranje upalnih mehanizama, koji imaju ključnu ulogu i u razvoju ateroskleroze. Sve je veći broj radova koji upućuju na psorijazu kao neovisni čimbenik rizika za razvoj moždanog i srčanog udara.
Abstract (english)
Psoriasis is a common, chronic systemic disease affecting at least 100 million people worldwide. It is presumed that psoriasis occurs in genetically susceptible individuals in whom specific environmental factors act as a trigger. Pathophysiology is complex and includes interactions between the innate and adaptive immune systems. Clinical presentation is characterized by erythematous lesions covered by scales on predilection sites such as extensor surfaces. There are some comorbidities that can develop with psoriasis and have a major impact on the quality of life, including psoriatic arthritis, depression, metabolic syndrome and cardiovascular disease. In the last few decades there has been increased interest in discovering the link between psoriasis and heart and brain ischemia. Higher incidence of major cardiovascular and cerebrovascular events, which include myocardial infarction and stroke, can be explained by several mechanisms. Patients with psoriasis tend to have higher prevalence of traditional risk factors for these life-threatening states, including higher body max index, obesity, diabetes, hyperlipidaemia and hypertension. Moreover, pathophysiology of psoriasis includes activation of inflammatory mechanisms, which have a pivotal role in the development of atherosclerosis. There is mounting evidence that psoriasis is an independent risk factor for myocardial infarction and stroke.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:105:594984
Study programmeTitle: Medicine
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2022-05-04 08:59:56