prikaz prve stranice dokumenta Ganglioside Composition Distinguishes Anaplastic Ganglioglioma Tumor Tissue from Peritumoral Brain Tissue: Complementary Mass Spectrometry and Thin-Layer Chromatography Evidence
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Scientific paper - Case study
Ganglioside Composition Distinguishes Anaplastic Ganglioglioma Tumor Tissue from Peritumoral Brain Tissue: Complementary Mass Spectrometry and Thin-Layer Chromatography Evidence
International Journal of Molecular Sciences, 22 (2021), 16; 8844. https://doi.org/10.3390/ijms22168844
Fabris, Dragana; Karmelić, Ivana; Muharemović, Hasan; Sajko, Tomislav; Jurilj, Mia; Potočki, Slavica; Novak, Ruđer; Vukelić, Željka

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Fabris, D., Karmelić, I., Muharemović, H., Sajko, T., Jurilj, M., Potočki, S. ... Vukelić, Ž. (2021). Ganglioside Composition Distinguishes Anaplastic Ganglioglioma Tumor Tissue from Peritumoral Brain Tissue: Complementary Mass Spectrometry and Thin-Layer Chromatography Evidence. International Journal of Molecular Sciences, 22. (16). doi: 10.3390/ijms22168844

Fabris, Dragana, et al. "Ganglioside Composition Distinguishes Anaplastic Ganglioglioma Tumor Tissue from Peritumoral Brain Tissue: Complementary Mass Spectrometry and Thin-Layer Chromatography Evidence." International Journal of Molecular Sciences, vol. 22, no. 16, 2021. https://doi.org/10.3390/ijms22168844

Fabris, Dragana, Ivana Karmelić, Hasan Muharemović, Tomislav Sajko, Mia Jurilj, Slavica Potočki, Ruđer Novak and Željka Vukelić. "Ganglioside Composition Distinguishes Anaplastic Ganglioglioma Tumor Tissue from Peritumoral Brain Tissue: Complementary Mass Spectrometry and Thin-Layer Chromatography Evidence." International Journal of Molecular Sciences 22, no. 16 (2021). https://doi.org/10.3390/ijms22168844

Fabris, D., et al. (2021) 'Ganglioside Composition Distinguishes Anaplastic Ganglioglioma Tumor Tissue from Peritumoral Brain Tissue: Complementary Mass Spectrometry and Thin-Layer Chromatography Evidence', International Journal of Molecular Sciences, 22(16). doi: 10.3390/ijms22168844

Fabris D, Karmelić I, Muharemović H, Sajko T, Jurilj M, Potočki S, and sur.. Ganglioside Composition Distinguishes Anaplastic Ganglioglioma Tumor Tissue from Peritumoral Brain Tissue: Complementary Mass Spectrometry and Thin-Layer Chromatography Evidence. International Journal of Molecular Sciences [Internet]. 2021 August 17 [cited 2024 April 25];22(16). doi: 10.3390/ijms22168844

D. Fabris, et al., "Ganglioside Composition Distinguishes Anaplastic Ganglioglioma Tumor Tissue from Peritumoral Brain Tissue: Complementary Mass Spectrometry and Thin-Layer Chromatography Evidence", International Journal of Molecular Sciences, vol. 22, no. 16, August 2021. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:528352. [Accessed: 25 April 2024]

Metadata
Title (english)Ganglioside Composition Distinguishes Anaplastic Ganglioglioma Tumor Tissue from Peritumoral Brain Tissue: Complementary Mass Spectrometry and Thin-Layer Chromatography Evidence
AuthorDragana Fabris
AuthorIvana Karmelić
AuthorHasan Muharemović
AuthorTomislav Sajko
AuthorMia Jurilj
AuthorSlavica Potočki
AuthorRuđer Novak
AuthorŽeljka Vukelić
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Medical Chemistry, Biochemistry and Clinical Chemistry)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Medical Biochemistry
Abstract (english)
Gangliosides serve as antitumor therapy targets and aberrations in their composition strongly correlate with tumor growth and invasiveness. Anaplastic ganglioglioma is a rare, poorly characterized, malignant neuronal–glial tumor type. We present the first comparative characterization of ganglioside composition in anaplastic ganglioglioma vs. peritumoral and healthy brain tissues by combining mass spectrometry and thin-layer chromatography. Anaplastic ganglioglioma ganglioside composition was highly distinguishable from both peritumoral and healthy tissue despite having five to six times lower total content. Ten out of twelve MS-identified ganglioside classes, defined by unique glycan residues, were represented by a large number and considerable abundance of individual species with different fatty acid residues (C16–C24) in ceramide portions. The major structurally identified class was tumor-associated GD3 (>50%) with 11 species; GD3 (d18:1/24:0) being the most abundant. The dominant sphingoid base residue in ganglioside ceramides was sphingosine (d18:1), followed by eicosasphingosine (d20:1). The peritumoral tissue ganglioside composition was estimated as normal. Specific ganglioside composition and large variability of ganglioside ceramide structures determined in anaplastic ganglioglioma demonstrate realistic ganglioside expression patterns and correspond to the profile of high-grade malignancy brain tumors.
Keywords (english)
Languageenglish
Publication typeScientific paper - Case study
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleInternational Journal of Molecular Sciences
Numberingvol. 22, no. 16, 8844
e-ISSN1422-0067
DOIhttps://doi.org/10.3390/ijms22168844
URN:NBNurn:nbn:hr:105:528352
Publication2021-08-17
Document URLhttps://www.mdpi.com/1422-0067/22/16/8844
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2022-05-12 07:30:35