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master's thesis
Genska terapija i njezina primjena u kliničkoj medicini
Zagreb: University of Zagreb, School of Medicine, 2021. urn:nbn:hr:105:344166
Šarčević, Andrea
University of Zagreb
School of Medicine
Department of Medical Biology

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

Cite this document

Šarčević, A. (2021). Genska terapija i njezina primjena u kliničkoj medicini (Master's thesis). Zagreb: University of Zagreb, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:344166

Šarčević, Andrea. "Genska terapija i njezina primjena u kliničkoj medicini." Master's thesis, University of Zagreb, School of Medicine, 2021. https://urn.nsk.hr/urn:nbn:hr:105:344166

Šarčević, Andrea. "Genska terapija i njezina primjena u kliničkoj medicini." Master's thesis, University of Zagreb, School of Medicine, 2021. https://urn.nsk.hr/urn:nbn:hr:105:344166

Šarčević, A. (2021). 'Genska terapija i njezina primjena u kliničkoj medicini', Master's thesis, University of Zagreb, School of Medicine, accessed 26 November 2024, https://urn.nsk.hr/urn:nbn:hr:105:344166

Šarčević A. Genska terapija i njezina primjena u kliničkoj medicini [Master's thesis]. Zagreb: University of Zagreb, School of Medicine; 2021 [cited 2024 November 26] Available at: https://urn.nsk.hr/urn:nbn:hr:105:344166

A. Šarčević, "Genska terapija i njezina primjena u kliničkoj medicini", Master's thesis, University of Zagreb, School of Medicine, Zagreb, 2021. Available at: https://urn.nsk.hr/urn:nbn:hr:105:344166

Metadata
TitleGenska terapija i njezina primjena u kliničkoj medicini
Title (english)Gene therapy and application in clinical medicine
AuthorAndrea Šarčević
MentorTamara Nikuševa Martić (mentor)
Committee memberFrane Paić (predsjednik povjerenstva)
Committee memberLjiljana Šerman (član povjerenstva)
Committee memberTamara Nikuševa Martić (član povjerenstva)
GranterUniversity of Zagreb
School of Medicine
(Department of Medical Biology)
Zagreb
Defense date and country2021-07-16, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Human Genetics, Genomics and Proteomics
Abstract
Pojam 'genska terapija' obično se odnosi na umetanje genskog materijala u stanicu radi pružanja terapijskog učinka. Prvobitno je proučavana kao način liječenja životno ugrožavajućih poremećaja (npr. karcinoma i kongenitalnih poremećaja) otpornih na uobičajeno liječenje. Međutim, genska terapija danas se razmatra i za mnoga stanja koja nisu opasna po život, za ona stanja koja utječu na kvalitetu života pacijenta. 1990. godine objavljena je prva klinička studija koja je koristila prijenos gena. Budući da je pokazala da je prijenos gena posredovan virusima siguran i praktičan, dovela je do pokretanja mnogih drugih studija. Od početka razvoja do danas, odobreno je više od 4000 kliničkih ispitivanja širom svijeta. Cilj ovog rada je prikazati podrijetlo i trenutni doseg genske terapije. Rad sažima povijest, osnovne strategije i alate genske terapije, te donosi pregled odobrenih lijekova genske terapije.
Abstract (english)
The term ‘gene therapy’ typically refers to insertion of a genetic material into cell to provide therapeutic effect. It was originally studied as a way to treat life-threatening disorders (e.g. cancers or congenital disorders) refractory to conventional treatment. However, gene therapy nowadays is considered for many non–life-threatening conditions, those affecting a patient’s quality of life. In 1990 the first clinical study using gene transfer was reported. Since it showed that viral gene transfer was safe and practical, it led to the launch of many other studies. From the beginning of development until today, more than 4000 clinical trials have been approved worldwide. This paper aims to review the origins and current reach of gene therapy. It summarizes the history, basic strategies and tools of gene therapy, and provides an overview of approved gene therapy drugs.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:105:344166
Study programmeTitle: Medicine
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2022-05-12 08:42:08