Hypothyroidism is a common metabolic disorder in the general population. Thyroid failure is more common in women and its prevalence rises with age. Hypothyroidism is characterised by low serum T4 and T3 levels and high TSH levels. Thyroid disease is associated with various metabolic abnormalities, due to the effects of thyroid hormones on nearly all major metabolic pathways. Dyslipidaemia is a common finding in patients with hypothyroidism, consisting of high levels of total and LDL cholesterol. Lipid abnormalities associated with hypothyroidism predispose to the development of atherosclerotic disease. Coexisting metabolic abnormalities in thyroid disease in combination with the thyroid hormone-induced hemodynamic alterations further contribute to increasing cardiovascular disease risk. Administration of substitution therapy with L-thyroxin significantly improves lipid metabolism abnormalities. The presence of overt hypothyroidism in patients with dyslipidaemia is not rare. Therefore, before starting hypolipidemic therapy, the evaluation of thyroid function is needed. It is imperative to firstly correct thyroid disfunction with thyroxine substitution therapy and then treat the underlying dyslipidaemia with statins.