prikaz prve stranice dokumenta Red cell distribution width is a potent prognostic parameter for in-hospital and post-discharge mortality in hospitalized coronavirus disease 2019 patients: a registry-based cohort study on 3941 patients
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Scientific paper - Original scientific paper
Red cell distribution width is a potent prognostic parameter for in-hospital and post-discharge mortality in hospitalized coronavirus disease 2019 patients: a registry-based cohort study on 3941 patients
Croatian Medical Journal, 63 (2022), 1; 44-52. https://doi.org/10.3325/cmj.2022.63.44
Lucijanić, Marko; Jordan, Ana; Jurin, Ivana; Piskač Živković, Nevenka; Sorić, Ena; Hadžibegović, Irzal; Atić, Armin; Stojić, Josip; Rudan, Diana; Jakšić, Ozren; Bušić, Nikolina; Đerek, Lovorka; Lukšić, Ivica; Baršić, Bruno

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Lucijanić, M., Jordan, A., Jurin, I., Piskač Živković, N., Sorić, E., Hadžibegović, I. ... Baršić, B. (2022). Red cell distribution width is a potent prognostic parameter for in-hospital and post-discharge mortality in hospitalized coronavirus disease 2019 patients: a registry-based cohort study on 3941 patients. Croatian Medical Journal, 63. (1), 44-52. doi: 10.3325/cmj.2022.63.44

Lucijanić, Marko, et al. "Red cell distribution width is a potent prognostic parameter for in-hospital and post-discharge mortality in hospitalized coronavirus disease 2019 patients: a registry-based cohort study on 3941 patients." Croatian Medical Journal, vol. 63, no. 1, 2022, pp. 44-52. https://doi.org/10.3325/cmj.2022.63.44

Lucijanić, Marko, Ana Jordan, Ivana Jurin, Nevenka Piskač Živković, Ena Sorić, Irzal Hadžibegović, Armin Atić, et al. "Red cell distribution width is a potent prognostic parameter for in-hospital and post-discharge mortality in hospitalized coronavirus disease 2019 patients: a registry-based cohort study on 3941 patients." Croatian Medical Journal 63, no. 1 (2022): 44-52. https://doi.org/10.3325/cmj.2022.63.44

Lucijanić, M., et al. (2022) 'Red cell distribution width is a potent prognostic parameter for in-hospital and post-discharge mortality in hospitalized coronavirus disease 2019 patients: a registry-based cohort study on 3941 patients', Croatian Medical Journal, 63(1), pp. 44-52. doi: 10.3325/cmj.2022.63.44

Lucijanić M, Jordan A, Jurin I, Piskač Živković N, Sorić E, Hadžibegović I, and sur.. Red cell distribution width is a potent prognostic parameter for in-hospital and post-discharge mortality in hospitalized coronavirus disease 2019 patients: a registry-based cohort study on 3941 patients. Croatian Medical Journal [Internet]. 2022 February 28 [cited 2024 December 28];63(1):44-52. doi: 10.3325/cmj.2022.63.44

M. Lucijanić, et al., "Red cell distribution width is a potent prognostic parameter for in-hospital and post-discharge mortality in hospitalized coronavirus disease 2019 patients: a registry-based cohort study on 3941 patients", Croatian Medical Journal, vol. 63, no. 1, pp. 44-52, February 2022. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:939595. [Accessed: 28 December 2024]

Metadata
Title (english)Red cell distribution width is a potent prognostic parameter for in-hospital and post-discharge mortality in hospitalized coronavirus disease 2019 patients: a registry-based cohort study on 3941 patients
AuthorMarko Lucijanić
AuthorAna Jordan
AuthorIvana Jurin
AuthorNevenka Piskač Živković
AuthorEna Sorić
AuthorIrzal Hadžibegović
AuthorArmin Atić
AuthorJosip Stojić
AuthorDiana Rudan
AuthorOzren Jakšić
AuthorNikolina Bušić
AuthorLovorka Đerek
AuthorIvica Lukšić
AuthorBruno Baršić
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Maxillofacial Surgery and Dentistry)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Surgery
Abstract (english)
Aim: To investigate clinical and prognostic associations of red cell distribution width (RDW) in hospitalized coronavirus disease 2019 (COVID-19) patients. ----- Methods: We retrospectively analyzed the records of 3941 consecutive COVID-19 patients admitted to a tertiary-level institution from March 2020 to March 2021 who had available RDW on admission. ----- Results: The median age was 74 years. The median Charlson comorbidity index (CCI) was 4. The majority of patients (84.1%) on admission presented with severe or critical COVID-19. Patients with higher RDW were significantly more likely to be older and female, to present earlier during infection, and to have higher comorbidity burden, worse functional status, and critical presentation of COVID-19 on admission. RDW was not significantly associated with C-reactive protein, occurrence of pneumonia, or need for oxygen supplementation on admission. During hospital stay, patients with higher RDW were significantly more likely to require high-flow oxygen therapy, mechanical ventilation, intensive care unit, and to experience prolonged immobilization, venous thromboembolism, bleeding, and bacterial sepsis. Thirty-day and post-hospital discharge mortality gradually increased with each rising RDW percent-point. In a series of multivariate Cox-regression models, RDW demonstrated robust prognostic properties at >14% cut-off level. This cut-off was associated with inferior 30-day and post-discharge survival independently of COVID-19 severity, age, and CCI; and with 30-day survival independently of COVID severity and established prognostic scores (CURB-65, 4C-mortality, COVID-gram and VACO-index). ----- Conclusion: RDW has a complex relationship with COVID-19-associated inflammatory state and is affected by prior comorbidities. RDW can improve the prognostication in hospitalized COVID-19 patients.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCroatian Medical Journal
Numberingvol. 63, no. 1, pp. 44-52
p-ISSN0353-9504
e-ISSN1332-8166
DOIhttps://doi.org/10.3325/cmj.2022.63.44
URN:NBNurn:nbn:hr:105:939595
Publication2022-02-28
Document URLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8895335/
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2022-05-20 07:38:06