prikaz prve stranice dokumenta The prognostic role of diabetes mellitus type 2 in the setting of hepatocellular carcinoma: a systematic review and meta-analysis
  Download
PDF 1.7 MB
Scientific paper - Review paper
The prognostic role of diabetes mellitus type 2 in the setting of hepatocellular carcinoma: a systematic review and meta-analysis
Croatian Medical Journal, 63 (2022), 2; 176-186. https://doi.org/10.3325/cmj.2022.63.176
Mrzljak, Anna; Cigrovski Berković, Maja; Giovanardi, Francesco; Quirino, Lai

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

Cite this document

Mrzljak, A., Cigrovski Berković, M., Giovanardi, F. & Quirino, L. (2022). The prognostic role of diabetes mellitus type 2 in the setting of hepatocellular carcinoma: a systematic review and meta-analysis. Croatian Medical Journal, 63. (2), 176-186. doi: 10.3325/cmj.2022.63.176

Mrzljak, Anna, et al. "The prognostic role of diabetes mellitus type 2 in the setting of hepatocellular carcinoma: a systematic review and meta-analysis." Croatian Medical Journal, vol. 63, no. 2, 2022, pp. 176-186. https://doi.org/10.3325/cmj.2022.63.176

Mrzljak, Anna, Maja Cigrovski Berković, Francesco Giovanardi and Lai Quirino. "The prognostic role of diabetes mellitus type 2 in the setting of hepatocellular carcinoma: a systematic review and meta-analysis." Croatian Medical Journal 63, no. 2 (2022): 176-186. https://doi.org/10.3325/cmj.2022.63.176

Mrzljak, A., et al. (2022) 'The prognostic role of diabetes mellitus type 2 in the setting of hepatocellular carcinoma: a systematic review and meta-analysis', Croatian Medical Journal, 63(2), pp. 176-186. doi: 10.3325/cmj.2022.63.176

Mrzljak A, Cigrovski Berković M, Giovanardi F, Quirino L. The prognostic role of diabetes mellitus type 2 in the setting of hepatocellular carcinoma: a systematic review and meta-analysis. Croatian Medical Journal [Internet]. 2022 April 30 [cited 2024 November 09];63(2):176-186. doi: 10.3325/cmj.2022.63.176

A. Mrzljak, M. Cigrovski Berković, F. Giovanardi and L. Quirino, "The prognostic role of diabetes mellitus type 2 in the setting of hepatocellular carcinoma: a systematic review and meta-analysis", Croatian Medical Journal, vol. 63, no. 2, pp. 176-186, April 2022. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:823316. [Accessed: 09 November 2024]

Metadata
Title (english)The prognostic role of diabetes mellitus type 2 in the setting of hepatocellular carcinoma: a systematic review and meta-analysis
AuthorAnna Mrzljak
AuthorMaja Cigrovski Berković
AuthorFrancesco Giovanardi
AuthorLai Quirino
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Internal Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Intensive Care
Abstract (english)
Aim: To evaluate the effect of diabetes mellitus type 2 (T2DM) on the outcomes after treatment of hepatocellular carcinoma (HCC). ----- Methods: PubMed and Cochrane Central Register of Controlled Trials Databases were systematically searched. Three HCC clinical outcomes were explored: death, progressive disease after locoregional therapies, and recurrence. Sub-analysis was performed according to the use of potentially curative (resection, transplantation, termo-ablation) or non-curative therapies. Odds ratios (OR) and 95% confidence intervals (CI) were calculated to compare the pooled data between T2DM and non-T2DM groups. ----- Results: A total of 27 studies were analyzed. Overall, 85.2% of articles were from Asia. T2MD was associated with an increased risk of death (OR 3.60; 95%CI 2.18-5.95; P<0.001), irrespective of the treatment approach: curative (OR 1.30 95%CI 1.09-1.54; P=0.003) or non-curative (OR 1.05; 95%CI 1.00-1.10; P=0.045), increased HCC recurrence (OR 1.30; 95%CI 1.03-1.63; P=0.03), and increased disease progressiveness (OR 1.24; 95%CI 1.09-1.41; P=0.001). ----- Conclusions: Current data provide strong evidence that T2DM unfavorably affects HCC progression and recurrence, and patients' survival after treatment, irrespective of the approach used.
Keywords (english)
Languageenglish
Publication typeScientific paper - Review paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCroatian Medical Journal
Numberingvol. 63, no. 2, pp. 176-186
p-ISSN0353-9504
e-ISSN1332-8166
DOIhttps://doi.org/10.3325/cmj.2022.63.176
URN:NBNurn:nbn:hr:105:823316
Publication2022-04-30
Document URLhttp://www.cmj.hr/2022/63/2/35505651.htm
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2022-05-20 12:20:26