prikaz prve stranice dokumenta Significant Associations of IgG Glycan Structures With Chronic Graft-Versus-Host Disease Manifestations: Results of the Cross-Sectional NIH Cohort Study
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Scientific paper - Original scientific paper
Significant Associations of IgG Glycan Structures With Chronic Graft-Versus-Host Disease Manifestations: Results of the Cross-Sectional NIH Cohort Study
Frontiers in Immunology, 12 (2021); 633214. https://doi.org/10.3389/fimmu.2021.633214
Prenc, Ema; Pulanić, Dražen; Pucic-Bakovic, Maja; Ugrina, Ivo; Desnica, Lana; Milošević, Milan; Pirsl, Filip; Mitchell, Sandra; Rose, Jeremy; Vrhovac, Radovan; Nemet, Damir; Lauc, Gordan; Pavletić, Steven Ž.

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Prenc, E., Pulanić, D., Pucic Bakovic, M., Ugrina, I., Desnica, L., Milošević, M. ... Pavletić, S. Ž. (2021). Significant Associations of IgG Glycan Structures With Chronic Graft-Versus-Host Disease Manifestations: Results of the Cross-Sectional NIH Cohort Study. Frontiers in Immunology, 12.. doi: 10.3389/fimmu.2021.633214

Prenc, Ema, et al. "Significant Associations of IgG Glycan Structures With Chronic Graft-Versus-Host Disease Manifestations: Results of the Cross-Sectional NIH Cohort Study." Frontiers in Immunology, vol. 12, 2021. https://doi.org/10.3389/fimmu.2021.633214

Prenc, Ema, Dražen Pulanić, Maja Pucic Bakovic, Ivo Ugrina, Lana Desnica, Milan Milošević, Filip Pirsl, et al. "Significant Associations of IgG Glycan Structures With Chronic Graft-Versus-Host Disease Manifestations: Results of the Cross-Sectional NIH Cohort Study." Frontiers in Immunology 12 (2021). https://doi.org/10.3389/fimmu.2021.633214

Prenc, E., et al. (2021) 'Significant Associations of IgG Glycan Structures With Chronic Graft-Versus-Host Disease Manifestations: Results of the Cross-Sectional NIH Cohort Study', Frontiers in Immunology, 12. doi: 10.3389/fimmu.2021.633214

Prenc E, Pulanić D, Pucic Bakovic M, Ugrina I, Desnica L, Milošević M, and sur.. Significant Associations of IgG Glycan Structures With Chronic Graft-Versus-Host Disease Manifestations: Results of the Cross-Sectional NIH Cohort Study. Frontiers in Immunology [Internet]. 2021 July 14 [cited 2024 November 22];12. doi: 10.3389/fimmu.2021.633214

E. Prenc, et al., "Significant Associations of IgG Glycan Structures With Chronic Graft-Versus-Host Disease Manifestations: Results of the Cross-Sectional NIH Cohort Study", Frontiers in Immunology, vol. 12, July 2021. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:644862. [Accessed: 22 November 2024]

Metadata
Title (english)Significant Associations of IgG Glycan Structures With Chronic Graft-Versus-Host Disease Manifestations: Results of the Cross-Sectional NIH Cohort Study
AuthorEma Prenc
AuthorDražen Pulanić
AuthorMaja Pucic-Bakovic
AuthorIvo Ugrina
AuthorLana Desnica
AuthorMilan Milošević
AuthorFilip Pirsl
AuthorSandra Mitchell
AuthorJeremy Rose
AuthorRadovan Vrhovac
AuthorDamir Nemet
AuthorGordan Lauc
AuthorSteven Ž. Pavletić
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Internal Medicine)
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Environmental and Occupational Health)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Public Health and Health Care
Health Ecology
Abstract (english)
Chronic graft-versus-host disease (cGvHD) is a systemic alloimmune and autoimmune disorder and a major late complication of allogeneic hematopoietic stem cell transplantation (alloHSCT). The disease is characterized by an altered homeostasis of the humoral immune response. Immunoglobulin G (IgG) glycoprotein is the main effector molecule of the humoral immune response. Changes in IgG glycosylation are associated with a number of autoimmune diseases. IgG glycosylation analysis was done by the means of liquid chromatography in the National Institutes of Health (NIH) cohort of 213 cGvHD patients. The results showed statistically significant differences with regards to cGvHD NIH joint/fascia and skin score, disease activity and intensity of systemic immunosuppression. ROC analysis confirmed that IgG glycosylation increases specificity and sensitivity of models using laboratory parameters and markers of inflammation associated with cGvHD (eosinophil count, complement components C3 and C4 and inflammation markers: albumin, CRP and thrombocyte count). This research shows that IgG glycosylation may play a significant role in cGvHD pathology. Further research could contribute to the understanding of the disease biology and lead to the clinical biomarker development to allow personalized approaches to chronic GvHD therapy.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleFrontiers in Immunology
Numberingvol. 12, 633214
e-ISSN1664-3224
DOIhttps://doi.org/10.3389/fimmu.2021.633214
URN:NBNurn:nbn:hr:105:644862
Publication2021-07-14
Document URLhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.633214/full
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2022-05-25 11:21:20