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Scientific paper - Original scientific paper
SARS-CoV-2 Seroprevalence and Neutralizing Antibody Response after the First and Second COVID-19 Pandemic Wave in Croatia
Pathogens, 10 (2021), 6; 774. https://doi.org/10.3390/pathogens10060774
Vilibić-Čavlek, Tatjana; Stevanovic, Vladimir; Ilić, Maja; Barbić, Ljubo; Capak, Krunoslav; Tabain, Irena; Lenicek Krleza, Jasna; Ferenc, Thomas; Hruskar, Zeljka; Zrinski Topić, Renata; Kaliterna, Vanja; Antolović-Požgain, Arlen; Kučinar, Jasmina; Koščak, Iva; Mayer, Dijana; Sviben, Mario; Antolasic, Ljiljana; Milasincic, Ljiljana; Bucić, Lovro; Ferenčak, Ivana; Kaić, Bernard More authors...

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Vilibić Čavlek, T., Stevanovic, V., Ilić, M., Barbić, Lj., Capak, K., Tabain, I. ... Kaić, B. (2021). SARS-CoV-2 Seroprevalence and Neutralizing Antibody Response after the First and Second COVID-19 Pandemic Wave in Croatia. Pathogens, 10. (6). doi: 10.3390/pathogens10060774

Vilibić Čavlek, Tatjana, et al. "SARS-CoV-2 Seroprevalence and Neutralizing Antibody Response after the First and Second COVID-19 Pandemic Wave in Croatia." Pathogens, vol. 10, no. 6, 2021. https://doi.org/10.3390/pathogens10060774

Vilibić Čavlek, Tatjana, Vladimir Stevanovic, Maja Ilić, Ljubo Barbić, Krunoslav Capak, Irena Tabain, Jasna Lenicek Krleza, et al. "SARS-CoV-2 Seroprevalence and Neutralizing Antibody Response after the First and Second COVID-19 Pandemic Wave in Croatia." Pathogens 10, no. 6 (2021). https://doi.org/10.3390/pathogens10060774

Vilibić Čavlek, T., et al. (2021) 'SARS-CoV-2 Seroprevalence and Neutralizing Antibody Response after the First and Second COVID-19 Pandemic Wave in Croatia', Pathogens, 10(6). doi: 10.3390/pathogens10060774

Vilibić Čavlek T, Stevanovic V, Ilić M, Barbić Lj, Capak K, Tabain I, and sur.. SARS-CoV-2 Seroprevalence and Neutralizing Antibody Response after the First and Second COVID-19 Pandemic Wave in Croatia. Pathogens [Internet]. 2021 June 20 [cited 2024 December 23];10(6). doi: 10.3390/pathogens10060774

T. Vilibić Čavlek, et al., "SARS-CoV-2 Seroprevalence and Neutralizing Antibody Response after the First and Second COVID-19 Pandemic Wave in Croatia", Pathogens, vol. 10, no. 6, June 2021. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:022605. [Accessed: 23 December 2024]

Metadata
Title (english)SARS-CoV-2 Seroprevalence and Neutralizing Antibody Response after the First and Second COVID-19 Pandemic Wave in Croatia
AuthorTatjana Vilibić-Čavlek
AuthorVladimir Stevanovic
AuthorMaja Ilić
AuthorLjubo Barbić
AuthorKrunoslav Capak
AuthorIrena Tabain
AuthorJasna Lenicek Krleza
AuthorThomas Ferenc
AuthorZeljka Hruskar
AuthorRenata Zrinski Topić
AuthorVanja Kaliterna
AuthorArlen Antolović-Požgain
AuthorJasmina Kučinar
AuthorIva Koščak
AuthorDijana Mayer
AuthorMario Sviben
AuthorLjiljana Antolasic
AuthorLjiljana Milasincic
AuthorLovro Bucić
AuthorIvana Ferenčak
AuthorBernard Kaić
MBZ: 235003
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Medical Microbiology and Parasitology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Medical Microbiology
Abstract (english)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel coronavirus with a pandemic spread. So far, a total of 349,910 SARS-CoV-2 cases and 7687 deaths were reported in Croatia. We analyzed the seroprevalence and neutralizing (NT) antibody response in the Croatian general population after the first (May–July 2020) and second (December 2020–February 2021) pandemic wave. Initial serological testing was performed using a commercial ELISA, with confirmation of reactive samples by a virus neutralization test (VNT). A significant difference in the overall seroprevalence rate was found after the first (ELISA 2.2%, VNT 0.2%) and second waves (ELISA 25.1%, VNT 18.7%). Seropositive individuals were detected in all age groups, with significant differences according to age. The lowest prevalence of NT antibodies was documented in the youngest (<10 years; 16.1%) and the oldest (60–69/70+ years; 16.0% and 12.8%, respectively) age groups. However, these age groups showed the highest median NT titers (32–64). In other groups, seropositivity varied from 19.3% to 21.5%. A significant weak positive correlation between binding antibody level as detected by ELISA and VNT titer (rho = 0.439, p < 0.001) was observed. SARS-CoV-2 NT antibody titers seem to be age-related, with the highest NT activity in children under 10 years and individuals above 50 years.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titlePathogens
Numberingvol. 10, no. 6, 774
e-ISSN2076-0817
DOIhttps://doi.org/10.3390/pathogens10060774
URN:NBNurn:nbn:hr:105:022605
Publication2021-06-20
Document URLhttps://www.mdpi.com/2076-0817/10/6/774
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2022-06-13 11:27:03