prikaz prve stranice dokumenta Midterm outcomes of venovenous extracorporeal membrane oxygenation as a bridge to lung transplantation: Comparison with nonbridged recipients
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Scientific paper - Original scientific paper
Midterm outcomes of venovenous extracorporeal membrane oxygenation as a bridge to lung transplantation: Comparison with nonbridged recipients
Journal of Cardiac Surgery, 37 (2022), 4; 747-759. https://doi.org/10.1111/jocs.16253
Sef, Davorin; Verzelloni Sef, Alessandra; Trkulja, Vladimir; Raj, Binu; Lees, Nicholas J.; Walker, Christopher; Mitchell, Jerry; Petrou, Mario; De Robertis, Fabio; Stock, Ulrich; McGovern, Ian

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Sef, D., Verzelloni Sef, A., Trkulja, V., Raj, B., Lees, N. J., Walker, C. ... McGovern, I. (2022). Midterm outcomes of venovenous extracorporeal membrane oxygenation as a bridge to lung transplantation: Comparison with nonbridged recipients. Journal of Cardiac Surgery, 37. (4), 747-759. doi: 10.1111/jocs.16253

Sef, Davorin, et al. "Midterm outcomes of venovenous extracorporeal membrane oxygenation as a bridge to lung transplantation: Comparison with nonbridged recipients." Journal of Cardiac Surgery, vol. 37, no. 4, 2022, pp. 747-759. https://doi.org/10.1111/jocs.16253

Sef, Davorin, Alessandra Verzelloni Sef, Vladimir Trkulja, Binu Raj, Nicholas J. Lees, Christopher Walker, Jerry Mitchell, et al. "Midterm outcomes of venovenous extracorporeal membrane oxygenation as a bridge to lung transplantation: Comparison with nonbridged recipients." Journal of Cardiac Surgery 37, no. 4 (2022): 747-759. https://doi.org/10.1111/jocs.16253

Sef, D., et al. (2022) 'Midterm outcomes of venovenous extracorporeal membrane oxygenation as a bridge to lung transplantation: Comparison with nonbridged recipients', Journal of Cardiac Surgery, 37(4), pp. 747-759. doi: 10.1111/jocs.16253

Sef D, Verzelloni Sef A, Trkulja V, Raj B, Lees NJ, Walker C, and sur.. Midterm outcomes of venovenous extracorporeal membrane oxygenation as a bridge to lung transplantation: Comparison with nonbridged recipients. Journal of Cardiac Surgery [Internet]. 2022 April [cited 2024 May 03];37(4):747-759. doi: 10.1111/jocs.16253

D. Sef, et al., "Midterm outcomes of venovenous extracorporeal membrane oxygenation as a bridge to lung transplantation: Comparison with nonbridged recipients", Journal of Cardiac Surgery, vol. 37, no. 4, pp. 747-759, April 2022. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:872095. [Accessed: 03 May 2024]

Metadata
Title (english)Midterm outcomes of venovenous extracorporeal membrane oxygenation as a bridge to lung transplantation: Comparison with nonbridged recipients
AuthorDavorin Sef
AuthorAlessandra Verzelloni Sef
AuthorVladimir Trkulja
AuthorBinu Raj
AuthorNicholas J. Lees
AuthorChristopher Walker
AuthorJerry Mitchell
AuthorMario Petrou
AuthorFabio De Robertis
AuthorUlrich Stock
AuthorIan McGovern
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Pharmacology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Pharmacology
Abstract (english)
Objectives: Venovenous extracorporeal membrane oxygenation (VV-ECMO) is increasingly being used in acutely deteriorating patients with end-stage lung disease as a bridge to transplantation (BTT). It can allow critically ill recipients to remain eligible for lung transplants (LTx) while reducing pretransplant deconditioning. We analyzed early- and midterm postoperative outcomes of patients on VV-ECMO as a BTT and the impact of preoperative VV-ECMO on posttransplant survival outcomes. ------ Methods: All consecutive LTx performed at our institution between January 2012 and December 2018 were analyzed. After matching, BTT patients were compared with nonbridged LTx recipients. ----- Results: Out of 297 transplanted patients, 21 (7.1%) were placed on VV-ECMO as a BTT. After matching, we observed similar 30-day mortality between BTT and non-BTT patients (4.6% vs. 6.6%, p = .083) despite a higher incidence of early postoperative complications (need for ECMO, delayed chest closure, and acute kidney injury). Furthermore, preoperative VV-ECMO did not appear associated with 30-day or 1-year mortality in both frequentist and Bayesian analysis (odds ratio [OR]: 0.35, 95% confidence interval: 0.03-3.49, p = .369; OR: 0.27, 95% credible interval: 0.01-3.82, p = 84.7%, respectively). In sensitivity analysis, both subgroups were similar in respect to 30-day (7.8% vs. 6.5%, p = .048) and 1-year mortality (12.5% vs. 18%, p = .154). ----- Conclusions: Patients with acute refractory respiratory failure while waiting for LTx represent a high-risk cohort of patients. VV-ECMO as a BTT is a reasonable strategy in adult patients with acceptable operative mortality and 1-year survival comparable to non-BTT patients.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titleJournal of Cardiac Surgery
Numberingvol. 37, no. 4, pp. 747-759
p-ISSN0886-0440
e-ISSN1540-8191
DOIhttps://doi.org/10.1111/jocs.16253
URN:NBNurn:nbn:hr:105:872095
Publication2022-04
Document URLhttps://onlinelibrary.wiley.com/doi/10.1111/jocs.16253
Type of resourceText
Access conditionsOpen access
Embargo expiration date: 2023-05-01
Terms of useLicence In copyright icon
Created on2022-06-15 12:43:04