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master's thesis
Povezanost polimorfizma gena za angiotenzin II receptor tip 1 s pojavnosti moždanog udara u ranijoj odrasloj dobi
Zagreb: University of Zagreb, School of Medicine, 2014. urn:nbn:hr:105:027597
Lovrić, Tena
University of Zagreb
School of Medicine
Department of Neurology

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

Cite this document

Lovrić, T. (2014). Povezanost polimorfizma gena za angiotenzin II receptor tip 1 s pojavnosti moždanog udara u ranijoj odrasloj dobi (Master's thesis). Zagreb: University of Zagreb, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:027597

Lovrić, Tena. "Povezanost polimorfizma gena za angiotenzin II receptor tip 1 s pojavnosti moždanog udara u ranijoj odrasloj dobi." Master's thesis, University of Zagreb, School of Medicine, 2014. https://urn.nsk.hr/urn:nbn:hr:105:027597

Lovrić, Tena. "Povezanost polimorfizma gena za angiotenzin II receptor tip 1 s pojavnosti moždanog udara u ranijoj odrasloj dobi." Master's thesis, University of Zagreb, School of Medicine, 2014. https://urn.nsk.hr/urn:nbn:hr:105:027597

Lovrić, T. (2014). 'Povezanost polimorfizma gena za angiotenzin II receptor tip 1 s pojavnosti moždanog udara u ranijoj odrasloj dobi', Master's thesis, University of Zagreb, School of Medicine, accessed 23 December 2024, https://urn.nsk.hr/urn:nbn:hr:105:027597

Lovrić T. Povezanost polimorfizma gena za angiotenzin II receptor tip 1 s pojavnosti moždanog udara u ranijoj odrasloj dobi [Master's thesis]. Zagreb: University of Zagreb, School of Medicine; 2014 [cited 2024 December 23] Available at: https://urn.nsk.hr/urn:nbn:hr:105:027597

T. Lovrić, "Povezanost polimorfizma gena za angiotenzin II receptor tip 1 s pojavnosti moždanog udara u ranijoj odrasloj dobi", Master's thesis, University of Zagreb, School of Medicine, Zagreb, 2014. Available at: https://urn.nsk.hr/urn:nbn:hr:105:027597

Metadata
TitlePovezanost polimorfizma gena za angiotenzin II receptor tip 1 s pojavnosti moždanog udara u ranijoj odrasloj dobi
Title (english)Linkage polymorphism of angiotensin II receptor type 1 with the incidence of stroke in early adulthood
AuthorTena Lovrić
MentorZdravka Poljaković (mentor)
Committee memberFran Borovečki (predsjednik povjerenstva)
Committee memberMario Habek (član povjerenstva)
Committee memberZdravka Poljaković (član povjerenstva)
GranterUniversity of Zagreb
School of Medicine
(Department of Neurology)
Zagreb
Defense date and country2014-07-15, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Neurology
Abstract
Moždani udar (MU) je prvi uzrok invaliditeta u Hrvatskoj. Prema mehanizmu nastanka može se podijeliti na ishemijski i hemoragijski. MU možemo smatrati poligenskim aterotrombotskim poremećajem. Pri tome sustav renin-angiotenzin (RAS) ima važnu ulogu. Angiotenzin II, dio RAS-a koji je snažan vazokonstriktor, svoje djelovanje vrši preko receptora AT1 i AT2. Gen koji kodira AT1 receptor (AT1R) ima više polimorfnih oblika. Fiziološko značenje polimorfizma AT1R A1166C nije sasvim jasno. Hipoteza ovog rada je da varijante gena AT1R mogu biti rizični čimbenik za MU u ranijoj odrasloj dobi. Stoga je ispitivana povezanost polimorfizma AT1R A1166C s pojavnosti ishemijskog moždanog udara (IMU) u ispitanika u dobi do 55. godine života. Ispitivanjem je obuhvaćena 301 osoba od kojih je 114 s akutnim IMU. Genotip AT1R A1166C, određen iz venske krvi, analiziran je metodom PCR/RFLP, a lokalizacija ishemije CT snimkama mozga. Statističkom analizom potvrđena je povezanost IMU s varijantama gena AT1R A1166C (p=0,004). Također je ustanovljena statistički značajna povezanost genotipova AT1R A1166C s lokalizacijom IMU. Rezultati ovog rada pokazuju značajnu povezanost genetičkih čimbenika s pojavnošću IMU i njegovim smještajem te upućuju na potrebu dodatnih ispitivanja.
Abstract (english)
Stroke is the most common cause of severe long-term disability in Croatia. Two main types of stroke include ischemic stroke (IS) and hemorrhagic stroke. Stroke can also be considered as atherothrombotic polygenic disorder where the renin-angiotensin system (RAS) plays an important role. The angiotensin II, a part of the RAS, acts through AT1 and AT2 receptors. The gene encoding for the AT1 receptor (AT1R) has several polymorphic forms. The physiological significance of AT1R A1166C polymorphism is not entirely clear. The hypothesis of this study was that the variant at the AT1R gene may be a risk factor for the incidence of stroke in early adulthood. The connection of AT1R A1166C polymorphism with the incidence of IS in patients under the age of 55 was examined. 301 persons were included in the study, among them 114 with acute IS. The AT1R A1166C genotype, determined from venous blood, was analyzed by PCR/RFLP, while localization of stroke was determined from brain CT scans. Statistical analysis confirmed the connection of IS with the variants of gene AT1R A1166C (p=0.004). Also significant connection of genotypes AT1R A1166C with the localization of stroke was found. The results of this study support the assumption of influence of genetic factors on stroke incidence and localization.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:105:027597
Study programmeTitle: Medicine
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2015-09-28 09:14:52