prikaz prve stranice dokumenta Divergent Effect of Central Incretin Receptors Inhibition in a Rat Model of Sporadic Alzheimer’s Disease
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Scientific paper - Original scientific paper
Divergent Effect of Central Incretin Receptors Inhibition in a Rat Model of Sporadic Alzheimer’s Disease
International Journal of Molecular Sciences, 23 (2022), 1; 548. https://doi.org/10.3390/ijms23010548
Osmanović Barilar, Jelena; Knezović, Ana; Homolak, Jan; Babić Perhoč, Ana; Šalković-Petrišić, Melita

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Osmanović Barilar, J., Knezović, A., Homolak, J., Babić Perhoč, A. & Šalković Petrišić, M. (2022). Divergent Effect of Central Incretin Receptors Inhibition in a Rat Model of Sporadic Alzheimer’s Disease. International Journal of Molecular Sciences, 23. (1). doi: 10.3390/ijms23010548

Osmanović Barilar, Jelena, et al. "Divergent Effect of Central Incretin Receptors Inhibition in a Rat Model of Sporadic Alzheimer’s Disease." International Journal of Molecular Sciences, vol. 23, no. 1, 2022. https://doi.org/10.3390/ijms23010548

Osmanović Barilar, Jelena, Ana Knezović, Jan Homolak, Ana Babić Perhoč and Melita Šalković Petrišić. "Divergent Effect of Central Incretin Receptors Inhibition in a Rat Model of Sporadic Alzheimer’s Disease." International Journal of Molecular Sciences 23, no. 1 (2022). https://doi.org/10.3390/ijms23010548

Osmanović Barilar, J., et al. (2022) 'Divergent Effect of Central Incretin Receptors Inhibition in a Rat Model of Sporadic Alzheimer’s Disease', International Journal of Molecular Sciences, 23(1). doi: 10.3390/ijms23010548

Osmanović Barilar J, Knezović A, Homolak J, Babić Perhoč A, Šalković Petrišić M. Divergent Effect of Central Incretin Receptors Inhibition in a Rat Model of Sporadic Alzheimer’s Disease. International Journal of Molecular Sciences [Internet]. 2022 January 04 [cited 2024 November 26];23(1). doi: 10.3390/ijms23010548

J. Osmanović Barilar, A. Knezović, J. Homolak, A. Babić Perhoč and M. Šalković Petrišić, "Divergent Effect of Central Incretin Receptors Inhibition in a Rat Model of Sporadic Alzheimer’s Disease", International Journal of Molecular Sciences, vol. 23, no. 1, January 2022. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:792760. [Accessed: 26 November 2024]

Metadata
Title (english)Divergent Effect of Central Incretin Receptors Inhibition in a Rat Model of Sporadic Alzheimer’s Disease
AuthorJelena Osmanović Barilar
AuthorAna Knezović
AuthorJan Homolak
AuthorAna Babić Perhoč
AuthorMelita Šalković-Petrišić
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Pharmacology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Pharmacology
Abstract (english)
The incretin system is an emerging new field that might provide valuable contributions to the research of both the pathophysiology and therapeutic strategies in the treatment of diabetes, obesity, and neurodegenerative disorders. This study aimed to explore the roles of central glucagon-like peptide-1 (GLP-1) and gastric inhibitory polypeptide (GIP) on cell metabolism and energy in the brain, as well as on the levels of these incretins, insulin, and glucose via inhibition of the central incretin receptors following intracerebroventricular administration of the respective antagonists in healthy rats and a streptozotocin-induced rat model of sporadic Alzheimer’s disease (sAD). Chemical ablation of the central GIP receptor (GIPR) or GLP-1 receptor (GLP-1R) in healthy and diseased animals indicated a region-dependent role of incretins in brain cell energy and metabolism and central incretin-dependent modulation of peripheral hormone secretion, markedly after GIPR inhibition, as well as a dysregulation of the GLP-1 system in experimental sAD.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleInternational Journal of Molecular Sciences
Numberingvol. 23, no. 1, 548
e-ISSN1422-0067
DOIhttps://doi.org/10.3390/ijms23010548
URN:NBNurn:nbn:hr:105:792760
Publication2022-01-04
Document URLhttps://www.mdpi.com/1422-0067/23/1/548
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2022-07-06 10:59:06