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Scientific paper - Original scientific paper
The Signature of Moderate Perinatal Hypoxia on Cortical Organization and Behavior: Altered PNN-Parvalbumin Interneuron Connectivity of the Cingulate Circuitries
Frontiers in Cell and Developmental Biology, 10 (2022); 810980. https://doi.org/10.3389/fcell.2022.810980
Trnski, Sara; Nikolić, Barbara; Ilić, Katarina; Drlje, Matea; Bobić-Rasonja, Mihaela; Darmopil, Sanja; Petanjek, Zdravko; Hranilović, Dubravka; Jovanov-Milošević, Nataša

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Trnski, S., Nikolić, B., Ilić, K., Drlje, M., Bobić Rasonja, M., Darmopil, S. ... Jovanov Milošević, N. (2022). The Signature of Moderate Perinatal Hypoxia on Cortical Organization and Behavior: Altered PNN-Parvalbumin Interneuron Connectivity of the Cingulate Circuitries. Frontiers in Cell and Developmental Biology, 10.. doi: 10.3389/fcell.2022.810980

Trnski, Sara, et al. "The Signature of Moderate Perinatal Hypoxia on Cortical Organization and Behavior: Altered PNN-Parvalbumin Interneuron Connectivity of the Cingulate Circuitries." Frontiers in Cell and Developmental Biology, vol. 10, 2022. https://doi.org/10.3389/fcell.2022.810980

Trnski, Sara, Barbara Nikolić, Katarina Ilić, Matea Drlje, Mihaela Bobić Rasonja, Sanja Darmopil, Zdravko Petanjek, Dubravka Hranilović and Nataša Jovanov Milošević. "The Signature of Moderate Perinatal Hypoxia on Cortical Organization and Behavior: Altered PNN-Parvalbumin Interneuron Connectivity of the Cingulate Circuitries." Frontiers in Cell and Developmental Biology 10 (2022). https://doi.org/10.3389/fcell.2022.810980

Trnski, S., et al. (2022) 'The Signature of Moderate Perinatal Hypoxia on Cortical Organization and Behavior: Altered PNN-Parvalbumin Interneuron Connectivity of the Cingulate Circuitries', Frontiers in Cell and Developmental Biology, 10. doi: 10.3389/fcell.2022.810980

Trnski S, Nikolić B, Ilić K, Drlje M, Bobić Rasonja M, Darmopil S, and sur.. The Signature of Moderate Perinatal Hypoxia on Cortical Organization and Behavior: Altered PNN-Parvalbumin Interneuron Connectivity of the Cingulate Circuitries. Frontiers in Cell and Developmental Biology [Internet]. 2022 February 28 [cited 2024 November 26];10. doi: 10.3389/fcell.2022.810980

S. Trnski, et al., "The Signature of Moderate Perinatal Hypoxia on Cortical Organization and Behavior: Altered PNN-Parvalbumin Interneuron Connectivity of the Cingulate Circuitries", Frontiers in Cell and Developmental Biology, vol. 10, February 2022. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:176415. [Accessed: 26 November 2024]

Metadata
Title (english)The Signature of Moderate Perinatal Hypoxia on Cortical Organization and Behavior: Altered PNN-Parvalbumin Interneuron Connectivity of the Cingulate Circuitries
AuthorSara Trnski
AuthorBarbara Nikolić
AuthorKatarina Ilić
AuthorMatea Drlje
AuthorMihaela Bobić-Rasonja
AuthorSanja Darmopil
AuthorZdravko Petanjek
AuthorDubravka Hranilović
AuthorNataša Jovanov-Milošević
Author's institutionUniversity of Zagreb
School of Medicine
(Croatian Institiute for Brain Research)
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Anatomy and Clinical Anatomy)
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Medical Biology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Anatomy
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Neuroscience
Abstract (english)
This study was designed in a rat model to determine the hallmarks of possible permanent behavioral and structural brain alterations after a single moderate hypoxic insult. Eighty-two Wistar Han (RccHan: WIST) rats were randomly subjected to hypoxia (pO2 73 mmHg/2 h) or normoxia at the first postnatal day. The substantially increased blood lactate, a significantly decreased cytochrome-C-oxygenase expression in the brain, and depleted subventricular zone suggested a high vulnerability of subset of cell populations to oxidative stress and consequent tissue response even after a single, moderate, hypoxic event. The results of behavioral tests (open-field, hole-board, social-choice, and T-maze) applied at the 30–45th and 70–85th postnatal days revealed significant hyperactivity and a slower pace of learning in rats subjected to perinatal hypoxia. At 3.5 months after hypoxic insult, the histochemical examination demonstrated a significantly increased number of specific extracellular matrix—perineuronal nets and increased parvalbumin expression in a subpopulation of interneurons in the medial and retrosplenial cingulate cortex of these animals. Conclusively, moderate perinatal hypoxia in rats causes a long-lasting reorganization of the connectivity in the cingulate cortex and consequent alterations of related behavioral and cognitive abilities. This non-invasive hypoxia model in the rat successfully and complementarily models the moderate perinatal hypoxic injury in fetuses and prematurely born human babies and may enhance future research into new diagnostic and therapeutic strategies for perinatal medicine.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleFrontiers in Cell and Developmental Biology
Numberingvol. 10, 810980
e-ISSN2296-634X
DOIhttps://doi.org/10.3389/fcell.2022.810980
URN:NBNurn:nbn:hr:105:176415
Publication2022-02-28
Document URLhttps://www.frontiersin.org/articles/10.3389/fcell.2022.810980/full
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2022-09-30 10:49:20