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Scientific paper - Original scientific paper
Mast Cells in the Mammalian Testis and Epididymis—Animal Models and Detection Methods
International Journal of Molecular Sciences, 23 (2022), 5; 2547. https://doi.org/10.3390/ijms23052547
Himelreich-Perić, Marta; Katušić-Bojanac, Ana; Hohšteter, Marko; Sinčić, Nino; Mužić-Radović, Vedrana; Ježek, Davor

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Himelreich Perić, M., Katušić Bojanac, A., Hohšteter, M., Sinčić, N., Mužić Radović, V. & Ježek, D. (2022). Mast Cells in the Mammalian Testis and Epididymis—Animal Models and Detection Methods. International Journal of Molecular Sciences, 23. (5). doi: 10.3390/ijms23052547

Himelreich Perić, Marta, et al. "Mast Cells in the Mammalian Testis and Epididymis—Animal Models and Detection Methods." International Journal of Molecular Sciences, vol. 23, no. 5, 2022. https://doi.org/10.3390/ijms23052547

Himelreich Perić, Marta, Ana Katušić Bojanac, Marko Hohšteter, Nino Sinčić, Vedrana Mužić Radović and Davor Ježek. "Mast Cells in the Mammalian Testis and Epididymis—Animal Models and Detection Methods." International Journal of Molecular Sciences 23, no. 5 (2022). https://doi.org/10.3390/ijms23052547

Himelreich Perić, M., et al. (2022) 'Mast Cells in the Mammalian Testis and Epididymis—Animal Models and Detection Methods', International Journal of Molecular Sciences, 23(5). doi: 10.3390/ijms23052547

Himelreich Perić M, Katušić Bojanac A, Hohšteter M, Sinčić N, Mužić Radović V, Ježek D. Mast Cells in the Mammalian Testis and Epididymis—Animal Models and Detection Methods. International Journal of Molecular Sciences [Internet]. 2022 February 25 [cited 2024 November 09];23(5). doi: 10.3390/ijms23052547

M. Himelreich Perić, A. Katušić Bojanac, M. Hohšteter, N. Sinčić, V. Mužić Radović and D. Ježek, "Mast Cells in the Mammalian Testis and Epididymis—Animal Models and Detection Methods", International Journal of Molecular Sciences, vol. 23, no. 5, February 2022. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:732111. [Accessed: 09 November 2024]

Metadata
Title (english)Mast Cells in the Mammalian Testis and Epididymis—Animal Models and Detection Methods
AuthorMarta Himelreich-Perić
AuthorAna Katušić-Bojanac
AuthorMarko Hohšteter
AuthorNino Sinčić
AuthorVedrana Mužić-Radović
AuthorDavor Ježek
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Histology and Embryology)
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Medical Biology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Cytology, Histology and Embryology
Abstract (english)
Mast cells (MCs) are an evolutionary well-conserved type of cells, mediating and modulating allergic responses in innate immunity and tissue remodeling after chronic inflammation. Among other tissues, they inhabit both the testis and epididymis. In the testis, MCs usually appear in the interstitial compartment in humans, but not in other standard experimental models, like rats and mice. MCs seem to be responsible for testicular tissue fibrosis in different causes of infertility. Although experimental animal models follow the effect on MC activation or penetration to the interstitial tissue like in humans to some extent, there is an inconsistency in the available literature regarding experimental design, animal strain, and detection methods used. This comprehensive review offers an insight into the literature on MCs in mammalian testes and epididymides. We aimed to find the most suitable model for research on MC and offer recommendations for future experimental designs. When using in vivo animal models, tunica albuginea incorporation and standard histological assessment need to be included. Domesticated boar strains kept in modified controlled conditions exhibit the highest similarity to the MC distribution in the human testis. 3D testicular models are promising but need further fine-tuning to become a valid model for MC investigation.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleInternational Journal of Molecular Sciences
Numberingvol. 23, no. 5, 2547
e-ISSN1422-0067
DOIhttps://doi.org/10.3390/ijms23052547
URN:NBNurn:nbn:hr:105:732111
Publication2022-02-25
ProjectNumber: KK.01.1.1.01.0008
Title (croatian): Znanstveni centar izvrsnosti za reproduktivnu i regenerativnu medicinu – istraživanja novih platformi i potencijala
Leader: Slobodan Vukičević
Jurisdiction: eu
Document URLhttps://www.mdpi.com/1422-0067/23/5/2547
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2022-10-05 08:36:12