prikaz prve stranice dokumenta Characterisation of subchondral bone repair following transplantation of bioreactor-manufactured autologous osteochondral graft in a sheep model
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Scientific paper - Original scientific paper
Characterisation of subchondral bone repair following transplantation of bioreactor-manufactured autologous osteochondral graft in a sheep model
European Cells and Materials, 43 (2022); 79-97. https://doi.org/10.22203/eCM.v043a08
Kostešić, Petar; Vukasović Barišić, Andreja; Erjavec, Igor; Pušić, M; Hudetz, Damir; Matičić, Dražen; Vnuk, D; Vučković, Mirta; Ivković, Alan

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Kostešić, P., Vukasović Barišić, A., Erjavec, I., Pušić, M., Hudetz, D., Matičić, D. ... Ivković, A. (2022). Characterisation of subchondral bone repair following transplantation of bioreactor-manufactured autologous osteochondral graft in a sheep model. European Cells and Materials, 43., 79-97. doi: 10.22203/eCM.v043a08

Kostešić, Petar, et al. "Characterisation of subchondral bone repair following transplantation of bioreactor-manufactured autologous osteochondral graft in a sheep model." European Cells and Materials, vol. 43, 2022, pp. 79-97. https://doi.org/10.22203/eCM.v043a08

Kostešić, Petar, Andreja Vukasović Barišić, Igor Erjavec, M Pušić, Damir Hudetz, Dražen Matičić, D Vnuk, Mirta Vučković and Alan Ivković. "Characterisation of subchondral bone repair following transplantation of bioreactor-manufactured autologous osteochondral graft in a sheep model." European Cells and Materials 43 (2022): 79-97. https://doi.org/10.22203/eCM.v043a08

Kostešić, P., et al. (2022) 'Characterisation of subchondral bone repair following transplantation of bioreactor-manufactured autologous osteochondral graft in a sheep model', European Cells and Materials, 43, pp. 79-97. doi: 10.22203/eCM.v043a08

Kostešić P, Vukasović Barišić A, Erjavec I, Pušić M, Hudetz D, Matičić D, and sur.. Characterisation of subchondral bone repair following transplantation of bioreactor-manufactured autologous osteochondral graft in a sheep model. European Cells and Materials [Internet]. 2022 March 02 [cited 2024 November 17];43:79-97. doi: 10.22203/eCM.v043a08

P. Kostešić, et al., "Characterisation of subchondral bone repair following transplantation of bioreactor-manufactured autologous osteochondral graft in a sheep model", European Cells and Materials, vol. 43, pp. 79-97, March 2022. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:328545. [Accessed: 17 November 2024]

Metadata
Title (english)Characterisation of subchondral bone repair following transplantation of bioreactor-manufactured autologous osteochondral graft in a sheep model
AuthorPetar Kostešić
AuthorAndreja Vukasović Barišić
AuthorIgor Erjavec
AuthorM Pušić
AuthorDamir Hudetz
AuthorDražen Matičić
AuthorD Vnuk
AuthorMirta Vučković
AuthorAlan Ivković
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Anatomy and Clinical Anatomy)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Anatomy
Abstract (english)
To date, no single approach to the treatment of osteochondral defects has resulted in satisfactory long-term outcomes, especially in a young and active human population. Emerging innovative tissue engineering strategies, including the use of composite scaffolds, novel cell sources and bioreactors, have shown promising results. However, these techniques need to be validated in translational animal models before they can be implemented in clinical practice. The aim of the present study was to analyse morphological and microarchitectural parameters during subchondral bone repair following transplantation of bioreactor-manufactured autologous osteochondral grafts in a sheep model. Animals were divided into 4 treatment groups: nasal chondrocyte (NC) autologous osteochondral grafts, articular chondrocyte (AC) autologous osteochondral grafts, cell-free scaffolds (CFS) and empty defects (EDs). After 6 weeks, 3 months and 12 months, bone remodelling was assessed by histology and micro-computed tomography (µCT). Although gradual remodelling and subchondral bone repair were seen in all groups across the time points, the best results were observed in the NC group. This was evidenced by the extent of new tissue formation and its best integration into the surrounding tissue in the NC group at all time points. This also suggested that nasal septum chondrocyte-seeded grafts adapted well to the biomechanical conditions of the loaded joint surface.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleEuropean Cells and Materials
Numberingvol. 43, pp. 79-97
e-ISSN1473-2262
DOIhttps://doi.org/10.22203/eCM.v043a08
URN:NBNurn:nbn:hr:105:328545
Publication2022-03-02
Document URLhttps://www.ecmjournal.org/papers/vol43/pdf/v043a08.pdf
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2022-10-11 11:53:28