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Scientific paper - Review paper
The role of statins in lung cancer
Archives of Medical Science, 18 (2021), 1; 141-152. https://doi.org/10.5114/aoms/123225
Amin, Fatemeh; Fathi, Farzaneh; Reiner, Željko; Banach, Maciej; Sahebkar, Amirhossein

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Amin, F., Fathi, F., Reiner, Ž., Banach, M. & Sahebkar, A. (2021). The role of statins in lung cancer. Archives of Medical Science, 18. (1), 141-152. doi: 10.5114/aoms/123225

Amin, Fatemeh, et al. "The role of statins in lung cancer." Archives of Medical Science, vol. 18, no. 1, 2021, pp. 141-152. https://doi.org/10.5114/aoms/123225

Amin, Fatemeh, Farzaneh Fathi, Željko Reiner, Maciej Banach and Amirhossein Sahebkar. "The role of statins in lung cancer." Archives of Medical Science 18, no. 1 (2021): 141-152. https://doi.org/10.5114/aoms/123225

Amin, F., et al. (2021) 'The role of statins in lung cancer', Archives of Medical Science, 18(1), pp. 141-152. doi: 10.5114/aoms/123225

Amin F, Fathi F, Reiner Ž, Banach M, Sahebkar A. The role of statins in lung cancer. Archives of Medical Science [Internet]. 2021 March 18 [cited 2024 December 02];18(1):141-152. doi: 10.5114/aoms/123225

F. Amin, F. Fathi, Ž. Reiner, M. Banach and A. Sahebkar, "The role of statins in lung cancer", Archives of Medical Science, vol. 18, no. 1, pp. 141-152, March 2021. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:167885. [Accessed: 02 December 2024]

Metadata
Title (english)The role of statins in lung cancer
AuthorFatemeh Amin
AuthorFarzaneh Fathi
AuthorŽeljko Reiner
AuthorMaciej Banach
AuthorAmirhossein Sahebkar
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Internal Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (english)
Lung cancer is one of the most common causes of cancer-related mortality in the 21st century. Statins as inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase not only reduce the cholesterol levels in the blood and decrease the risk of cardiovascular disease but may also play an important role in the prevention and treatment of lung cancer. Statins have several antitumor properties including the ability to reduce cell proliferation and angiogenesis, decrease invasion and synergistic suppression of lung cancer progression. Statins induce tumor cell apoptosis by inhibition of downstream products such as small GTP-binding proteins, Rho, Ras and Rac, which are dependent on isoprenylation. Statins reduce angiogenesis in tumors by down-regulation of pro-angiogenic factors, such as vascular endothelial growth factor. In this review, the feasibility and efficacy of statins in the prevention and treatment of lung cancer are discussed.
Keywords (english)
Languageenglish
Publication typeScientific paper - Review paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleArchives of Medical Science
Numberingvol. 18, no. 1, pp. 141-152
p-ISSN1734-1922
e-ISSN1896-9151
DOIhttps://doi.org/10.5114/aoms/123225
URN:NBNurn:nbn:hr:105:167885
Publication2021-03-18
Document URLhttps://www.archivesofmedicalscience.com/The-role-of-statins-in-lung-cancer,123225,0,2.html
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) icon
Created on2022-10-24 11:05:20