prikaz prve stranice dokumenta Cardiac troponins predict mortality and cardiovascular outcomes in patients with peripheral artery disease: A systematic review and meta‐analysis of adjusted observational studies
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Scientific paper - Review paper
Cardiac troponins predict mortality and cardiovascular outcomes in patients with peripheral artery disease: A systematic review and meta‐analysis of adjusted observational studies
Clinical Cardiology, 45 (2022), 2; 198-204. https://doi.org/10.1002/clc.23776
Vrsalović, Mislav; Vrsalović Presečki, Ana; Aboyans, Victor

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Vrsalović, M., Vrsalović Presečki, A. & Aboyans, V. (2022). Cardiac troponins predict mortality and cardiovascular outcomes in patients with peripheral artery disease: A systematic review and meta‐analysis of adjusted observational studies. Clinical Cardiology, 45. (2), 198-204. doi: 10.1002/clc.23776

Vrsalović, Mislav, et al. "Cardiac troponins predict mortality and cardiovascular outcomes in patients with peripheral artery disease: A systematic review and meta‐analysis of adjusted observational studies." Clinical Cardiology, vol. 45, no. 2, 2022, pp. 198-204. https://doi.org/10.1002/clc.23776

Vrsalović, Mislav, Ana Vrsalović Presečki and Victor Aboyans. "Cardiac troponins predict mortality and cardiovascular outcomes in patients with peripheral artery disease: A systematic review and meta‐analysis of adjusted observational studies." Clinical Cardiology 45, no. 2 (2022): 198-204. https://doi.org/10.1002/clc.23776

Vrsalović, M., Vrsalović Presečki, A. and Aboyans, V. (2022) 'Cardiac troponins predict mortality and cardiovascular outcomes in patients with peripheral artery disease: A systematic review and meta‐analysis of adjusted observational studies', Clinical Cardiology, 45(2), pp. 198-204. doi: 10.1002/clc.23776

Vrsalović M, Vrsalović Presečki A, Aboyans V. Cardiac troponins predict mortality and cardiovascular outcomes in patients with peripheral artery disease: A systematic review and meta‐analysis of adjusted observational studies. Clinical Cardiology [Internet]. 2022 February [cited 2024 December 24];45(2):198-204. doi: 10.1002/clc.23776

M. Vrsalović, A. Vrsalović Presečki and V. Aboyans, "Cardiac troponins predict mortality and cardiovascular outcomes in patients with peripheral artery disease: A systematic review and meta‐analysis of adjusted observational studies", Clinical Cardiology, vol. 45, no. 2, pp. 198-204, February 2022. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:186429. [Accessed: 24 December 2024]

Metadata
Title (english)Cardiac troponins predict mortality and cardiovascular outcomes in patients with peripheral artery disease: A systematic review and meta‐analysis of adjusted observational studies
AuthorMislav Vrsalović
AuthorAna Vrsalović Presečki
AuthorVictor Aboyans
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Internal Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (english)
Background: A significant proportion of patients (pts) with peripheral artery disease (PAD) have concomitant coronary artery disease and polyvascular involvement contributes to increased risk of death and unfavorable cardiovascular events. ----- Hypothesis: Cardiac troponins are associated with adverse cardiovascular outcomes in PAD pts. ----- Methods: We systematically searched Medline and Scopus to identify all observational cohort studies published before June 2021 (combining terms "troponin," "peripheral artery disease," "peripheral arterial disease," "intermittent claudication," and "critical limb ischemia") that evaluated the prognostic impact of troponin rise on admission on all-cause mortality and/or major cardiovascular events (MACEs; composite of myocardial infarction, stroke, and cardiovascular death) in PAD pts followed up at least 6 months. A meta-analysis was conducted using the generic inverse variance method. Heterogeneity between studies was investigated using Cochrane's Q test and I2 statistic. ----- Results: Eight studies were included in the final analysis (5313 pts) with a median follow-up of 27 months (interquartile range: 12-59 months). The prevalence of troponin positivity was 5.3% (range: 4.4%-8.7%) in pts with intermittent claudication, and 62.6% (range: 33.6%-85%) in critical limb ischemia. Elevated troponins were significantly associated with an increased risk of all-cause mortality (hazard ratio [HR]: 2.85, 95% confidence interval [CI]: 2.28-3.57; I2 = 50.97%), and MACE (HR: 2.58, 95% CI: 2.04-3.26; I2 = 4.00%) without publication bias (p = .24 and p = .10, respectively). ----- Conclusion: Troponin rise on admission is associated with adverse long-term cardiovascular outcomes in symptomatic PAD.
Keywords (english)
Languageenglish
Publication typeScientific paper - Review paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleClinical Cardiology
Numberingvol. 45, no. 2, pp. 198-204
p-ISSN0160-9289
e-ISSN1932-8737
DOIhttps://doi.org/10.1002/clc.23776
URN:NBNurn:nbn:hr:105:186429
Publication2022-02
Document URLhttps://onlinelibrary.wiley.com/doi/10.1002/clc.23776
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2022-10-26 07:33:10