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doctoral thesis
Utjecaj unosa joda na funkcionalne parametre štitnjače u trudnica
Zagreb: University of Zagreb, School of Medicine, 2022. urn:nbn:hr:105:003942
Gladić Nenadić, Vedrana
University of Zagreb
School of Medicine

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Gladić Nenadić, V. (2022). Utjecaj unosa joda na funkcionalne parametre štitnjače u trudnica (Doctoral thesis). Zagreb: University of Zagreb, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:003942

Gladić Nenadić, Vedrana. "Utjecaj unosa joda na funkcionalne parametre štitnjače u trudnica." Doctoral thesis, University of Zagreb, School of Medicine, 2022. https://urn.nsk.hr/urn:nbn:hr:105:003942

Gladić Nenadić, Vedrana. "Utjecaj unosa joda na funkcionalne parametre štitnjače u trudnica." Doctoral thesis, University of Zagreb, School of Medicine, 2022. https://urn.nsk.hr/urn:nbn:hr:105:003942

Gladić Nenadić, V. (2022). 'Utjecaj unosa joda na funkcionalne parametre štitnjače u trudnica', Doctoral thesis, University of Zagreb, School of Medicine, accessed 22 November 2024, https://urn.nsk.hr/urn:nbn:hr:105:003942

Gladić Nenadić V. Utjecaj unosa joda na funkcionalne parametre štitnjače u trudnica [Doctoral thesis]. Zagreb: University of Zagreb, School of Medicine; 2022 [cited 2024 November 22] Available at: https://urn.nsk.hr/urn:nbn:hr:105:003942

V. Gladić Nenadić, "Utjecaj unosa joda na funkcionalne parametre štitnjače u trudnica", Doctoral thesis, University of Zagreb, School of Medicine, Zagreb, 2022. Available at: https://urn.nsk.hr/urn:nbn:hr:105:003942

Metadata
TitleUtjecaj unosa joda na funkcionalne parametre štitnjače u trudnica
Title (english)The impact of iodine intake on functional parameters of the thyroid in pregnant women
AuthorVedrana Gladić Nenadić
MentorTomislav Jukić (mentor)
Committee memberDražen Huić (predsjednik povjerenstva)
Committee memberTina Dušek (član povjerenstva)
Committee memberKrunoslav Kuna (član povjerenstva)
GranterUniversity of Zagreb
School of Medicine
Zagreb
Defense date and country2022-09-02, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Nuclear Medicine
Universal decimal classification
(UDC)		616 - Pathology. Clinical medicine
Abstract
Istraživanje je proučavalo utjecaj unosa joda na funkciju i volumen štitnjače (Tvol) u trudnica na području Zagreba. Unos joda je određen mjerenjem koncentracije joda u urinu (UIC). Cilj istraživanja bio je utvrditi unos joda i utjecaj dodatnog unosa joda putem dodataka prehrani u trudnica u svim trimestrima trudnoće na funkciju i Tvol, vrijednost tireoglobulina (Tg) kao biljega unosa joda u trudnoći i utjecaj morfoloških promjena štitnjače na njegovu vrijednost. Hipoteza istraživanja je da trudnice koje ne uzimaju dodatke prehrani s jodom imaju niže vrijednosti UIC, niže koncentracije slobodnog tiroksina (FT4), više koncentracije tireotropina (TSH) i Tg-a u serumu i veći Tvol. Istraživanje je obuhvatilo 91 trudnicu koje su uzimale i 100 trudnica koje nisu uzimale dodatke prehrani s jodom. Medijan UIC u trudnica koje nisu uzimale dodatke prehrani s jodom iznosio je 158 μg/L, a koje su uzimale 169 μg/L, što je dostatan unos joda u obje skupine i cjelokupnom uzorku. Trudnice koje nisu uzimale dodatke prehrani s jodom imale su statistički značajno niže vrijednosti FT4, a više vrijednosti Tg-a i Tvol (p˂0.05). Tireoglobulin je koristan biljeg unosa joda u trudnoći. Difuzne promjene štitnjače značajno povećavaju razinu Tg-a u serumu. Nije utvrđena korelacija Tg-a i ostalih ispitivanih prametara štitnjače.
Abstract (english)
The study investigated the impact of iodine intake on thyroid function (TF) and thyroid volume (Tvol) in pregnant women from Zagreb. Iodine status was determined by measurement of urinary iodine concentration (UIC). The aim of the study was to asess iodine intake and the impact of iodine supplementation (IS) in pregnant women in all trimesters of pregnancy on TF and Tvol, the value of Thyroglobulin (Tg) as potential biomarker of iodine intake in pregnancy as well as the influence of morphological changes on Tg measurement. It is hypothesized that pregnant women without IS have lower UIC values, lower free thyroxine (FT4), higher thyrotropin (TSH) and higher serum Tg concentrations, as well as higher Tvol. We enrolled 91 pregnant women with IS and 100 pregnant women without IS. Median UIC was 158 μg/L in pregnant women without IS, and 169 μg/L in pregnant women with IS, indicating sufficient iodine intake in both groups as well as in overall sample. Pregnant women without IS had significantly lower FT4, and higher Tg and Tvol values (p˂0.05). Thyroglobulin is a valuable biomarker of iodine intake in pregnancy. Diffuse thyroid pattern increases Tg values. There was no correlation between Tg and other thyroid parameters.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:105:003942
Study programmeTitle: Biomedicine and Health Sciences
Study programme type: university
Study level: postgraduate
Academic / professional title: doktor/doktorica znanosti, područje biomedicine i zdravstvo (doktor/doktorica znanosti, područje biomedicine i zdravstvo)
Type of resourceText
Extent100 str.
File originBorn digital
Access conditionsOpen access
Embargo expiration date: 2024-09-02
Terms of useLicence In copyright icon
Created on2022-10-28 11:18:11