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Scientific paper - Original scientific paper
DOAC Dipstick Testing Can Reliably Exclude the Presence of Clinically Relevant DOAC Concentrations in Circulation
Thrombosis and Haemostasis, 122 (2022), 9; 1542-1548. https://doi.org/10.1055/a-1753-2748
Margetić, Sandra; Ćelap, Ivana; Lovrenčić Huzjan, Arijana; Bosnar Puretić, Marijana; Šupraha Goreta, Sandra; Glojnarić, Anesa Čajević; Delić Brkljačić, Diana; Mioč, Pavao; Harenberg, Job; Hetjens, Svetlana; Weiss, Christel

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Margetić, S., Ćelap, I., Lovrenčić Huzjan, A., Bosnar Puretić, M., Šupraha Goreta, S., Glojnarić, A. Č. ... Weiss, C. (2022). DOAC Dipstick Testing Can Reliably Exclude the Presence of Clinically Relevant DOAC Concentrations in Circulation. Thrombosis and Haemostasis, 122. (9), 1542-1548. doi: 10.1055/a-1753-2748

Margetić, Sandra, et al. "DOAC Dipstick Testing Can Reliably Exclude the Presence of Clinically Relevant DOAC Concentrations in Circulation." Thrombosis and Haemostasis, vol. 122, no. 9, 2022, pp. 1542-1548. https://doi.org/10.1055/a-1753-2748

Margetić, Sandra, Ivana Ćelap, Arijana Lovrenčić Huzjan, Marijana Bosnar Puretić, Sandra Šupraha Goreta, Anesa Čajević Glojnarić, Diana Delić Brkljačić, et al. "DOAC Dipstick Testing Can Reliably Exclude the Presence of Clinically Relevant DOAC Concentrations in Circulation." Thrombosis and Haemostasis 122, no. 9 (2022): 1542-1548. https://doi.org/10.1055/a-1753-2748

Margetić, S., et al. (2022) 'DOAC Dipstick Testing Can Reliably Exclude the Presence of Clinically Relevant DOAC Concentrations in Circulation', Thrombosis and Haemostasis, 122(9), pp. 1542-1548. doi: 10.1055/a-1753-2748

Margetić S, Ćelap I, Lovrenčić Huzjan A, Bosnar Puretić M, Šupraha Goreta S, Glojnarić AČ, and sur.. DOAC Dipstick Testing Can Reliably Exclude the Presence of Clinically Relevant DOAC Concentrations in Circulation. Thrombosis and Haemostasis [Internet]. 2022 September [cited 2024 November 26];122(9):1542-1548. doi: 10.1055/a-1753-2748

S. Margetić, et al., "DOAC Dipstick Testing Can Reliably Exclude the Presence of Clinically Relevant DOAC Concentrations in Circulation", Thrombosis and Haemostasis, vol. 122, no. 9, pp. 1542-1548, September 2022. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:863334. [Accessed: 26 November 2024]

Metadata
Title (english)DOAC Dipstick Testing Can Reliably Exclude the Presence of Clinically Relevant DOAC Concentrations in Circulation
AuthorSandra Margetić
AuthorIvana Ćelap
AuthorArijana Lovrenčić Huzjan
AuthorMarijana Bosnar Puretić
AuthorSandra Šupraha Goreta
AuthorAnesa Čajević Glojnarić
AuthorDiana Delić Brkljačić
AuthorPavao Mioč
AuthorJob Harenberg
AuthorSvetlana Hetjens
AuthorChristel Weiss
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Internal Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (english)
In certain clinical situations, it is necessary to determine whether clinically relevant plasma levels of direct oral anticoagulants (DOACs) are present. We examined whether qualitative testing of DOACs in urine samples can exclude DOAC plasma concentrations of ≥30 ng/mL. This prospective single-center cohort study included consecutive patients treated with an oral direct factor Xa inhibitor (DXI) (apixaban, n = 31, rivaroxaban, n = 53) and direct thrombin inhibitor (DTI) (dabigatran, n = 44). We aimed to define the negative predictive value (NPV) and other statistical parameters of detecting DXIs and DTIs by DOAC Dipstick at plasma concentrations of ≥30 ng/mL. We also determined the best-fit threshold plasma levels using chromogenic substrate assays by logistic regression analysis. Between July 2020 and July 2021, 128 eligible patients (mean age 66 years, 55 females) were included into the study. The NPVs and sensitivities for DXI and DTI of DOAC Dipstick were 100% at ≥30 ng/mL plasma, for specificities 6 and 21% and for positive predictive values 62 and 72%, respectively. All diagnostic statistical tests improved to values between 86 and 100% at best-fitting plasma thresholds of ≥14 ng/mL for DXI and ≥19 ng/mL for DTI. Visual analysis using the DOAC Dipstick was 100% in agreement with that of the optoelectronic DOASENSE Reader for all the three DOACs. DOAC Dipstick testing can reliably exclude the presence of DOACs in urine samples at best-fitting thresholds of >14 and >19 ng/mL in plasma. The performance of the DOAC Dipstick at detecting lower DOAC concentrations in plasma requires confirmation.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleThrombosis and Haemostasis
Numberingvol. 122, no. 9, pp. 1542-1548
p-ISSN0340-6245
e-ISSN2567-689X
DOIhttps://doi.org/10.1055/a-1753-2748
URN:NBNurn:nbn:hr:105:863334
Publication2022-09
ProjectNumber: IP-2016-06-8208
Title (croatian): Novi oralni antikoagulansi: povezanost koncentracije lijeka i antikoagulantnog učinka
Acronym: LAB-NOAC
Leader: Sandra Margetić
Jurisdiction: Croatia
Funding stream: IP
Document URLhttp://www.thieme-connect.de/DOI/DOI?10.1055/a-1753-2748
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2022-11-14 12:21:48