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Scientific paper - Original scientific paper
Novel Therapeutic Effects in Rat Spinal Cord Injuries: Recovery of the Definitive and Early Spinal Cord Injury by the Administration of Pentadecapeptide BPC 157 Therapy
Current Issues in Molecular Biology, 44 (2022), 5; 1901-1927. https://doi.org/10.3390/cimb44050130
Perović, Darko; Milavić, Marija; Dokuzović, Stjepan; Krezić, Ivan; Gojković, Slaven; Vranes, Hrvoje; Bebek, Igor; Bilić, Vide; Somun, Nenad; Brižić, Ivan; Skorak, Ivan; Hriberski, Klaudija; Sikirić, Sunčana; Lovrić, Eva; Štrbe, Sanja; Kubat, Milovan; Boban Blagaić, Alenka; Škrtić, Anita; Seiwerth, Sven; Sikirić, Predrag More authors...

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Perović, D., Milavić, M., Dokuzović, S., Krezić, I., Gojković, S., Vranes, H. ... Sikirić, P. (2022). Novel Therapeutic Effects in Rat Spinal Cord Injuries: Recovery of the Definitive and Early Spinal Cord Injury by the Administration of Pentadecapeptide BPC 157 Therapy. Current Issues in Molecular Biology, 44. (5), 1901-1927. doi: 10.3390/cimb44050130

Perović, Darko, et al. "Novel Therapeutic Effects in Rat Spinal Cord Injuries: Recovery of the Definitive and Early Spinal Cord Injury by the Administration of Pentadecapeptide BPC 157 Therapy." Current Issues in Molecular Biology, vol. 44, no. 5, 2022, pp. 1901-1927. https://doi.org/10.3390/cimb44050130

Perović, Darko, Marija Milavić, Stjepan Dokuzović, Ivan Krezić, Slaven Gojković, Hrvoje Vranes, Igor Bebek, et al. "Novel Therapeutic Effects in Rat Spinal Cord Injuries: Recovery of the Definitive and Early Spinal Cord Injury by the Administration of Pentadecapeptide BPC 157 Therapy." Current Issues in Molecular Biology 44, no. 5 (2022): 1901-1927. https://doi.org/10.3390/cimb44050130

Perović, D., et al. (2022) 'Novel Therapeutic Effects in Rat Spinal Cord Injuries: Recovery of the Definitive and Early Spinal Cord Injury by the Administration of Pentadecapeptide BPC 157 Therapy', Current Issues in Molecular Biology, 44(5), pp. 1901-1927. doi: 10.3390/cimb44050130

Perović D, Milavić M, Dokuzović S, Krezić I, Gojković S, Vranes H, and sur.. Novel Therapeutic Effects in Rat Spinal Cord Injuries: Recovery of the Definitive and Early Spinal Cord Injury by the Administration of Pentadecapeptide BPC 157 Therapy. Current Issues in Molecular Biology [Internet]. 2022 April 27 [cited 2024 December 25];44(5):1901-1927. doi: 10.3390/cimb44050130

D. Perović, et al., "Novel Therapeutic Effects in Rat Spinal Cord Injuries: Recovery of the Definitive and Early Spinal Cord Injury by the Administration of Pentadecapeptide BPC 157 Therapy", Current Issues in Molecular Biology, vol. 44, no. 5, pp. 1901-1927, April 2022. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:066238. [Accessed: 25 December 2024]

Metadata
Title (english)Novel Therapeutic Effects in Rat Spinal Cord Injuries: Recovery of the Definitive and Early Spinal Cord Injury by the Administration of Pentadecapeptide BPC 157 Therapy
AuthorDarko Perović
AuthorMarija Milavić
AuthorStjepan Dokuzović
AuthorIvan Krezić
AuthorSlaven Gojković
AuthorHrvoje Vranes
AuthorIgor Bebek
AuthorVide Bilić
AuthorNenad Somun
AuthorIvan Brižić
AuthorIvan Skorak
AuthorKlaudija Hriberski
AuthorSunčana Sikirić
AuthorEva Lovrić
AuthorSanja Štrbe
MBZ: 319335
AuthorMilovan Kubat
AuthorAlenka Boban Blagaić
AuthorAnita Škrtić
AuthorSven Seiwerth
AuthorPredrag Sikirić
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Pharmacology)
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Pathology)
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Forensic Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Forensic Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Pathology
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Pharmacology
Abstract (english)
Recently, marked therapeutic effects pertaining to the recovery of injured rat spinal cords (1 min compression injury of the sacrocaudal spinal cord (S2-Co1) resulting in tail paralysis) appeared after a single intraperitoneal administration of the stable gastric pentadecapeptide BPC 157 at 10 min post-injury. Besides the demonstrated rapid and sustained recovery (1 year), we showed the particular points of the immediate effect of the BPC 157 therapy that began rapidly after its administration, (i) soon after injury (10 min), or (ii) later (4 days), in the rats with a definitive spinal cord injury. Specifically, in counteracting spinal cord hematoma and swelling, (i) in rats that had undergone acute spinal cord injury, followed by intraperitoneal BPC 157 application at 10 min, we focused on the first 10–30 min post-injury period (assessment of gross, microscopic, and gene expression changes). Taking day 4 post-injury as the definitive injury, (ii) we focused on the immediate effects after the BPC 157 intragastric application over 20 min of the post-therapy period. Comparable long-time recovery was noted in treated rats which had definitive tail paralysis: (iii) the therapy was continuously given per orally in drinking water, beginning at day 4 after injury and lasting one month after injury. BPC 157 rats presented only discrete edema and minimal hemorrhage and increased Nos1, Nos2, and Nos3 values (30 min post-injury, (i)) or only mild hemorrhage, and only discrete vacuolation of tissue (day 4, (ii)). In the day 4–30 post-injury study (iii), BPC 157 rats rapidly presented tail function recovery, and no demyelination process (Luxol fast blue staining).
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCurrent Issues in Molecular Biology
Numberingvol. 44, no. 5, pp. 1901-1927
e-ISSN1467-3045
DOIhttps://doi.org/10.3390/cimb44050130
URN:NBNurn:nbn:hr:105:066238
Publication2022-04-27
Document URLhttps://www.mdpi.com/1467-3045/44/5/130
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2022-12-07 15:07:46