prikaz prve stranice dokumenta Reduced Platelet MAO-B Activity Is Associated with Psychotic, Positive, and Depressive Symptoms in PTSD
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Scientific paper - Original scientific paper
Reduced Platelet MAO-B Activity Is Associated with Psychotic, Positive, and Depressive Symptoms in PTSD
Biomolecules, 12 (2022), 5; 736. https://doi.org/10.3390/biom12050736
Repovečki, Senka; Nedić Erjavec, Gordana; Uzun, Suzana; Tudor, Lucija; Nikolac Perković, Matea; Konjevod, Marcela; Kozumplik, Oliver; Švob Štrac, Dubravka; Kovačić Petrović, Zrnka; Mimica, Ninoslav; Pivac, Nela

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Repovečki, S., Nedić Erjavec, G., Uzun, S., Tudor, L., Nikolac Perković, M., Konjevod, M. ... Pivac, N. (2022). Reduced Platelet MAO-B Activity Is Associated with Psychotic, Positive, and Depressive Symptoms in PTSD. Biomolecules, 12. (5). doi: 10.3390/biom12050736

Repovečki, Senka, et al. "Reduced Platelet MAO-B Activity Is Associated with Psychotic, Positive, and Depressive Symptoms in PTSD." Biomolecules, vol. 12, no. 5, 2022. https://doi.org/10.3390/biom12050736

Repovečki, Senka, Gordana Nedić Erjavec, Suzana Uzun, Lucija Tudor, Matea Nikolac Perković, Marcela Konjevod, Oliver Kozumplik, et al. "Reduced Platelet MAO-B Activity Is Associated with Psychotic, Positive, and Depressive Symptoms in PTSD." Biomolecules 12, no. 5 (2022). https://doi.org/10.3390/biom12050736

Repovečki, S., et al. (2022) 'Reduced Platelet MAO-B Activity Is Associated with Psychotic, Positive, and Depressive Symptoms in PTSD', Biomolecules, 12(5). doi: 10.3390/biom12050736

Repovečki S, Nedić Erjavec G, Uzun S, Tudor L, Nikolac Perković M, Konjevod M, and sur.. Reduced Platelet MAO-B Activity Is Associated with Psychotic, Positive, and Depressive Symptoms in PTSD. Biomolecules [Internet]. 2022 May 23 [cited 2024 November 22];12(5). doi: 10.3390/biom12050736

S. Repovečki, et al., "Reduced Platelet MAO-B Activity Is Associated with Psychotic, Positive, and Depressive Symptoms in PTSD", Biomolecules, vol. 12, no. 5, May 2022. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:663190. [Accessed: 22 November 2024]

Metadata
Title (english)Reduced Platelet MAO-B Activity Is Associated with Psychotic, Positive, and Depressive Symptoms in PTSD
AuthorSenka Repovečki
AuthorGordana Nedić Erjavec
AuthorSuzana Uzun
AuthorLucija Tudor
AuthorMatea Nikolac Perković
AuthorMarcela Konjevod
AuthorOliver Kozumplik
AuthorDubravka Švob Štrac
AuthorZrnka Kovačić Petrović
AuthorNinoslav Mimica
AuthorNela Pivac
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Psychiatry and Psychological Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Psychiatry
Abstract (english)
Post-traumatic stress disorder (PTSD) is a trauma-related disorder. Platelet monoamine oxidase (MAO-B) is a peripheral biomarker associated with various symptoms in different psychopathologies, but its role in PTSD or different symptoms in PTSD is not clear. This study elucidated the association between platelet MAO-B activity and clinical symptoms occurring in PTSD. Platelet MAO-B activity was determined in 1053 male Caucasian subjects: 559 war veterans with PTSD (DSM-5 criteria), 62 combat exposed veterans who did not develop PTSD, and 432 non-combat exposed healthy controls. Clinical symptoms in PTSD were determined using CAPS and PANSS. Platelet MAO-B activity, controlled for the effect of smoking, was significantly increased in PTSD with severe versus mild and moderate traumatic symptoms, and was significantly decreased in PTSD subjects with severe versus mild positive, psychotic, and depressive symptoms. This finding was further confirmed with reduced platelet MAO-B activity in PTSD veterans with severe versus mild individual items of the PANSS-depressed, PANSS-psychotic, and PANSS-positive subscales. Altered platelet MAO-B activity, controlled for the possible confounders, was associated with the development and severity of different symptoms occurring in PTSD. These findings confirmed the role of platelet MAO-B activity as a peripheral marker of various psychopathological symptoms.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleBiomolecules
Numberingvol. 12, no. 5, 736
e-ISSN2218-273X
DOIhttps://doi.org/10.3390/biom12050736
URN:NBNurn:nbn:hr:105:663190
Publication2022-05-23
ProjectNumber: IP-2014-09-4289
Title (croatian): Genomski i glikanski biomarkeri PTSP-a
Title (english): Genomic and glycomic biomarkers for PTSD
Acronym: GlycoGenePTSD
Leader: Nela Pivac
Jurisdiction: Croatia
Funding stream: IP
Document URLhttps://www.mdpi.com/2218-273X/12/5/736
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2022-12-12 08:05:10