prikaz prve stranice dokumenta Patterns of Disease Progression and Outcome of Patients With Testicular Seminoma Who Relapse After Adjuvant or Curative Radiation Therapy
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Scientific paper - Original scientific paper
Patterns of Disease Progression and Outcome of Patients With Testicular Seminoma Who Relapse After Adjuvant or Curative Radiation Therapy
International Journal of Radiation Oncology*Biology*Physics, 113 (2022), 4; 825-832. https://doi.org/10.1016/j.ijrobp.2022.03.021
(International Germ Cell Cancer Collaborative Group) Terbuch, Angelika; Posch, Florian; Bauernhofer, Thomas; Jost, Philipp J.; Partl, Richard; Stranzl-Lawatsch, Heidi; Baciarello, Giulia; Fizazi, Karim; Giannatempo, Patrizia; Verzoni, Elena; Sweeney, Christopher; Ravi, Praful; Tran, Ben; Basso, Umberto; White, Jeff; Vincenzi, Bruno; Oing, Christoph; Cutuli, Hernan Javier; Dieckmann, Klaus Peter; Gamulin, Marija; Chovanec, Michal; Fankhauser, Christian Daniel; Heidenreich, Axel; Mohamad, Osama; Thibault, Constance; Fischer, Stefanie; Gillessen, Silke More authors...

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Terbuch, A., Posch, F., Bauernhofer, T., Jost, P. J., Partl, R., Stranzl Lawatsch, H. ... Gillessen, S. (2022). Patterns of Disease Progression and Outcome of Patients With Testicular Seminoma Who Relapse After Adjuvant or Curative Radiation Therapy. International Journal of Radiation Oncology*Biology*Physics, 113. (4), 825-832. doi: 10.1016/j.ijrobp.2022.03.021

Terbuch, Angelika, et al. "Patterns of Disease Progression and Outcome of Patients With Testicular Seminoma Who Relapse After Adjuvant or Curative Radiation Therapy." International Journal of Radiation Oncology*Biology*Physics, vol. 113, no. 4, 2022, pp. 825-832. https://doi.org/10.1016/j.ijrobp.2022.03.021

Terbuch, Angelika, Florian Posch, Thomas Bauernhofer, Philipp J. Jost, Richard Partl, Heidi Stranzl Lawatsch, Giulia Baciarello, et al. "Patterns of Disease Progression and Outcome of Patients With Testicular Seminoma Who Relapse After Adjuvant or Curative Radiation Therapy." International Journal of Radiation Oncology*Biology*Physics 113, no. 4 (2022): 825-832. https://doi.org/10.1016/j.ijrobp.2022.03.021

Terbuch, A., et al. (2022) 'Patterns of Disease Progression and Outcome of Patients With Testicular Seminoma Who Relapse After Adjuvant or Curative Radiation Therapy', International Journal of Radiation Oncology*Biology*Physics, 113(4), pp. 825-832. doi: 10.1016/j.ijrobp.2022.03.021

Terbuch A, Posch F, Bauernhofer T, Jost PJ, Partl R, Stranzl Lawatsch H, and sur.. Patterns of Disease Progression and Outcome of Patients With Testicular Seminoma Who Relapse After Adjuvant or Curative Radiation Therapy. International Journal of Radiation Oncology*Biology*Physics [Internet]. 2022 July 15 [cited 2024 November 26];113(4):825-832. doi: 10.1016/j.ijrobp.2022.03.021

A. Terbuch, et al., "Patterns of Disease Progression and Outcome of Patients With Testicular Seminoma Who Relapse After Adjuvant or Curative Radiation Therapy", International Journal of Radiation Oncology*Biology*Physics, vol. 113, no. 4, pp. 825-832, July 2022. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:588653. [Accessed: 26 November 2024]

Metadata
Title (english)Patterns of Disease Progression and Outcome of Patients With Testicular Seminoma Who Relapse After Adjuvant or Curative Radiation Therapy
AuthorAngelika Terbuch
AuthorFlorian Posch
AuthorThomas Bauernhofer
AuthorPhilipp J. Jost
AuthorRichard Partl
AuthorHeidi Stranzl-Lawatsch
AuthorGiulia Baciarello
AuthorKarim Fizazi
AuthorPatrizia Giannatempo
AuthorElena Verzoni
AuthorChristopher Sweeney
AuthorPraful Ravi
AuthorBen Tran
AuthorUmberto Basso
AuthorJeff White
AuthorBruno Vincenzi
AuthorChristoph Oing
AuthorHernan Javier Cutuli
AuthorKlaus Peter Dieckmann
AuthorMarija Gamulin
AuthorMichal Chovanec
AuthorChristian Daniel Fankhauser
AuthorAxel Heidenreich
AuthorOsama Mohamad
AuthorConstance Thibault
AuthorStefanie Fischer
AuthorSilke Gillessen
CollaborationInternational Germ Cell Cancer Collaborative Group
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Clinical Oncology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Oncology
Abstract (english)
Purpose: Radiation therapy is a possible treatment strategy for patients with testicular seminoma after orchiectomy in clinical stage I or II disease. Little is known about the outcome of patients who experience a relapse after radiation therapy. ----- Methods and materials: Data from 61 patients who relapsed after adjuvant or curative radiation therapy from 17 centers in 11 countries were collected and retrospectively analyzed. Primary outcomes were disease-free and overall survival. Secondary outcomes were time to relapse, stage at relapse, treatment for relapse, and rate of febrile neutropenia during chemotherapy for relapse. ----- Results: With a median follow-up of 9.9 years (95% confidence interval [CI], 7.5-10.9), we found a 5-year disease-free survival of 90% (95% CI, 79-95) and a 5-year overall survival of 98% (95% CI, 89-100). Sixty-six percent of patients had stage III disease at time of relapse and 93% of patients fell into the good prognosis group per the International Germ Cell Cancer Collaborative Group classification. The median time to relapse after radiation therapy was 15.6 months (95% CI, 12-23). Twenty-two (36%) patients relapsed more than 2 years after radiation therapy and 7 (11.5%) patients relapsed more than 5 years after radiation therapy. One-third of relapses was detected owing to patients' symptoms, whereas two-thirds of relapses were detected during routine follow-up. The majority (93%) of cases were treated with cisplatin-based chemotherapy. The rate of febrile neutropenia during chemotherapy was 35%. Five patients experienced a second relapse. At last follow-up, 55 patients (90%) were alive without disease. Only 1 patient died owing to disease progression. ----- Conclusions: Cisplatin-based chemotherapy for patients with seminoma who have relapsed after treatment with radiation therapy alone leads to excellent outcomes. Patients and physicians should be aware of possible late relapses after radiation therapy.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleInternational Journal of Radiation Oncology*Biology*Physics
Numberingvol. 113, no. 4, pp. 825-832
p-ISSN0360-3016
DOIhttps://doi.org/10.1016/j.ijrobp.2022.03.021
URN:NBNurn:nbn:hr:105:588653
Publication2022-07-15
Document URLhttps://linkinghub.elsevier.com/retrieve/pii/S0360301622002620
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2022-12-15 09:26:34