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master's thesis
Treatment options for infections caused by carbapenem-resistant Klebsiella pneumoniae isolates
Zagreb: University of Zagreb, School of Medicine, 2022. urn:nbn:hr:105:469607
Csenar, Luka Joakim
University of Zagreb
School of Medicine

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Csenar, L. J. (2022). Treatment options for infections caused by carbapenem-resistant Klebsiella pneumoniae isolates (Master's thesis). Zagreb: University of Zagreb, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:469607

Csenar, Luka Joakim. "Treatment options for infections caused by carbapenem-resistant Klebsiella pneumoniae isolates." Master's thesis, University of Zagreb, School of Medicine, 2022. https://urn.nsk.hr/urn:nbn:hr:105:469607

Csenar, Luka Joakim. "Treatment options for infections caused by carbapenem-resistant Klebsiella pneumoniae isolates." Master's thesis, University of Zagreb, School of Medicine, 2022. https://urn.nsk.hr/urn:nbn:hr:105:469607

Csenar, L. J. (2022). 'Treatment options for infections caused by carbapenem-resistant Klebsiella pneumoniae isolates', Master's thesis, University of Zagreb, School of Medicine, accessed 27 December 2024, https://urn.nsk.hr/urn:nbn:hr:105:469607

Csenar LJ. Treatment options for infections caused by carbapenem-resistant Klebsiella pneumoniae isolates [Master's thesis]. Zagreb: University of Zagreb, School of Medicine; 2022 [cited 2024 December 27] Available at: https://urn.nsk.hr/urn:nbn:hr:105:469607

L. J. Csenar, "Treatment options for infections caused by carbapenem-resistant Klebsiella pneumoniae isolates", Master's thesis, University of Zagreb, School of Medicine, Zagreb, 2022. Available at: https://urn.nsk.hr/urn:nbn:hr:105:469607

Metadata
TitleTreatment options for infections caused by carbapenem-resistant Klebsiella pneumoniae isolates
Title (croatian)Mogućnosti liječenja infekcija uzrokovanih sojevima Klebsiella pneumoniae rezistentnima na karbapeneme
AuthorLuka Joakim Csenar
MentorLuka Bielen (mentor)
Committee memberLuka Bielen (predsjednik povjerenstva)
Committee memberBranka Bedenić (član povjerenstva)
Committee memberJasenka Markeljević (član povjerenstva)
GranterUniversity of Zagreb
School of Medicine
Zagreb
Defense date and country2022-03-11, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract
Carbapenem-resistant Klebsiella pneumoniae poses a global public health threat. Newly emerging resistances deplete the antibiotic armamentarium and represent a therapeutic challenge even for the most experienced physician. Epidemiological data on carbapenemresistant K. pneumoniae show high mortality rates and growing resistance rates. Carbapenems are broad-spectrum β-lactam antibiotics being used in complicated and hard to treat infections including those caused by K. pneumoniae. The acquisition of various resistance genes enabled K. pneumoniae to produce carbapenemases. Distinct carbapenemases provide drug targets for novel β-lactamase inhibitors. However, some K. pneumoniae isolates show high adaptability resulting in resistance against new drugs, only leaving salvage therapy as last option. This graduate thesis provides insight into carbapenem resistance mechanisms in K. pneumoniae. Furthermore, rational approaches regarding the possible options for the treatment of infections caused by carbapenem-resistant K. pneumoniae isolates are outlined. The therapeutic regimen is mainly based upon the class of carbapenemase being produced by the K. pneumoniae strain causing the infection. Screening by molecular microbiological methods enables infection prevention and control, as well as prompt initiation of therapy.
Abstract (croatian)
Klebsiella pneumoniae rezistentna na karbapeneme predstavlja veliki globalni javnozdravstveni problem. Pojava novih mehanizama rezistencije dovodi do smanjenja broja učinkovitih antibiotika zbog čega liječenje ovih infekcija predstavlja izazov čak i najiskusnijim kliničarima. Epidemiološki podatci o K. pneumoniae rezistentnoj na karbapeneme ukazuju na globalni porast rezistencije i na visoku stopu smrtnosti od infekcija uzrokovanih ovim mikroorganizmom. Karbapenemi su β-laktamski antibiotici širokog spektra. Koriste se za komplicirane teško lječive infekcije, u koje ubrajamo i one uzrokovane K. pneumoniae. Stjecanje različitih gena rezistencije omogućilo je K. pneumoniae produkciju karbapenemaza. Različite karbapenemaze predstavljaju mete za liječenje novim inhibitorima β-laktamaze. Međutim, neki izolati K. pneumoniae pokazuju visoku sposobnost adaptacije, što dovodi do razvoja rezistencije i na nove lijekove. Time kao posljednja opcija kliničarima preostaju samo antibiotici zadnje linije liječenja. U ovom se diplomskom radu opisuju mehanizmi rezistencije K. pneumoniae na karbapeneme. Raspravlja se o mogućnostima liječenja infekcija uzrokovanih izolatima K. pneumoniae rezistentnima na karbapeneme. Terapijska shema prvenstveno se temelji na klasi karbapenemaze koju producira soj K. pneumoniae koji je doveo do infekcije. Probir molekularnim mikrobiološkim testiranjem omogućava prevenciju i kontrolu širenja infekcija, kao i rano započinjanje terapije.
Keywords
Keywords (croatian)
Languageenglish
URN:NBNurn:nbn:hr:105:469607
Study programmeTitle: Medicine (in English language)
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2022-12-19 08:49:49