Ischemic heart disease is the leading cause of death in the world despite significant progress in the prevention, diagnosis and treatment. Through last twenty years in development of invasive cardiology, percutaneous coronary intervention (PCI) plays an important role in treatment of the hardest form of coronary heart disease - acute coronary syndrome. Nowadays, percutaneous coronary intervention with stent implantation is gold standard in the treatment of acute coronary syndrome. Although the incidence of local complications is not high, we should not ignore them, and therefore it is extremely important to improve the techniques and aspire to a better treatment and faster recovery of patients. Radial approach in performing PCI proved to be equally effective and safe comparing to the femoral approach. Numerous studies show many advantages of radial approach, especially when it comes to local complications. Bleeding is the most common local complication at the puncture site, while others such as pseudoaneurysm, AV fistula, thrombosis or embolism are less frequent. The latest meta-analyses proved statistically significant reduction in the incidence of bleeding in percutaneous coronary interventions performed by transradial access. Because of significantly lower incidence of local complications while proceeding percutaneous coronary intervention, European Society of Cardiology in latest guidelines recommends the radial approach.