Post-traumatic stress disorder is a chronic and disabling disorder, which poses a significant public health issue for which existing therapies are only somewhat effective, and ongoing investigation and research are still being conducted to find the most appropriate treatment. The disorder affects 15- 24% of the population who were exposed to a traumatic event in their lifetime. Although 60 percent to 50 percent of men and women, respectively, experienced traumatic or life-threatening circumstances in their life, the development of the disorder is still somewhat more common among high-risk populations, such as refugees, veterans, unmarried, and those of lower socioeconomic background, younger age, and low education. If left untreated, PTSD can have severe and fatal consequences on the individual life and can impair daily and basic functions. Today, the first-line treatment is psychotherapy. Newer approaches are being developed to target the specific damage induced by the trauma. CBT and exposure therapy are the main methods for treating patients with PTSD. However, medical therapy can target more prominent somatic symptoms like hypervigilance, sleep problems, hyperarousal, and other comorbidities such as depression, anxiety, and suicidality. This review is aimed to display the treatment options for treating PTSD and to explore the success and effectiveness of each type of treatment, alone and combined.