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master's thesis
Cellular models in neuroscience
Zagreb: University of Zagreb, School of Medicine, 2022. urn:nbn:hr:105:664497
Novak, Andrej
University of Zagreb
School of Medicine

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Novak, A. (2022). Cellular models in neuroscience (Master's thesis). Zagreb: University of Zagreb, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:664497

Novak, Andrej. "Cellular models in neuroscience." Master's thesis, University of Zagreb, School of Medicine, 2022. https://urn.nsk.hr/urn:nbn:hr:105:664497

Novak, Andrej. "Cellular models in neuroscience." Master's thesis, University of Zagreb, School of Medicine, 2022. https://urn.nsk.hr/urn:nbn:hr:105:664497

Novak, A. (2022). 'Cellular models in neuroscience', Master's thesis, University of Zagreb, School of Medicine, accessed 28 March 2025, https://urn.nsk.hr/urn:nbn:hr:105:664497

Novak A. Cellular models in neuroscience [Master's thesis]. Zagreb: University of Zagreb, School of Medicine; 2022 [cited 2025 March 28] Available at: https://urn.nsk.hr/urn:nbn:hr:105:664497

A. Novak, "Cellular models in neuroscience", Master's thesis, University of Zagreb, School of Medicine, Zagreb, 2022. Available at: https://urn.nsk.hr/urn:nbn:hr:105:664497

Metadata
TitleCellular models in neuroscience
Title (croatian)Stanični modeli u neuroznanosti
AuthorAndrej Novak
MentorSvjetlana Kalanj Bognar (mentor)
Committee memberSvjetlana Kalanj Bognar (predsjednik povjerenstva)
Committee memberGoran Sedmak (član povjerenstva)
Committee memberZdravko Petanjek (član povjerenstva)
GranterUniversity of Zagreb
School of Medicine
Zagreb
Defense date and country2022-03-09, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Neuroscience
Abstract
In 1952, Alan Hodgkin and Andrew Huxley produced one of the most prolific and significant scientific paper in the history of physiology that was a result of their collaboration that first started in 1939. Their research at the Physiological Laboratory in Cambridge and the Marine Biological Association Laboratory in Plymouth oered key insights into nerve cell excitability. Their legacy includes not only our knowledge of how voltage-gated ion channels influence propagating action potentials,... More but also the framework for modelling and analyzing ion channel kinetics as they managed to capture the random openings and closings of a plethora of ion channels into just four macroscopic variables; the membrane voltage and three gating variables - much like Fick’s law provides a macroscopic description of chemical diusion in terms of concentration without explicitly considering the underlying Brownian motion of myriad molecules. To this date, it remains one of the greatest illustrations of how phenomenological description combined with mathematical modelling may reveal processes long before they can be detected firsthand (for example by visualization). Their work was awarded a Nobel Prize in Physiology or Medicine in 1963, and served as a basis for numerous other Nobel Prize-winning work. The most notable examples are the work of Erwin Neher and Bert Sakmann’s ”discoveries concerning the function of single ion channels in cells” ( in 1976), and in 2003, Roderick MacKinnon’s ”structural and mechanistic studies of ion channels”. One could argue that this was a starting point for cellular neurophysiology - a broad subfield of neuroscience that studies neurons at the cellular level. In this thesis, we will focus on their results, as well as on a number of dierent models that arose from it and have sparked the creation of new and attractive research directions of neural models. These types of models are increasingly recognized by both experimentalists and theoreticians as they are opening unique multidisciplinary collaborative research and educational opportunities. Less
Abstract (english)
Godine 1952. Alan Hodgkin i Andrew Huxley objavili su jedan od najznačajnijih znanstvenih radova u povijesti fiziologije koji je bio rezultat njihove suradnje zapoˇcete ve´c 1939. Njihovo istraživanje u Physiological Laboratory u Cambridgeu i Laboratoriju Marine Biological Association Laboratorija u Plymouthu je ponudilo kljuˇcne uvide u pobudljivost živčanih stanica. Njihovo nasljede ne uključuje samo naše znanje o tome kako naponski vodeni ionski kanali utječu na propagaciju akcijskih... More potencijala, već i okvir za modeliranje i analizu kinetike ionskih kanala budući da su nasumično otvaranje i zatvaranje mnoštva ionskih kanala uspjeli modelirati samo s četiri makroskopske varijable; napon membrane i tri varijable provodenja - što se može usporediti s Fickovim zakonom koji nudi makroskopski opis difuzije u smislu koncentracije bez eksplicitnog razmatranja temeljnog Brownovog gibanja bezbrojnih molekula. Njihov rad do danas ostaje jedna od najvećih ilustracija kako fenomenološki opis u kombinaciji s matematičkim modeliranjem može otkriti procese mnogo prije nego što se mogu opaziti npr. direktnom vizualizacijom. Njihov je rad nagraden Nobelovom nagradom za fiziologiju i medicinu 1963. godine i poslužio je kao osnova za brojne druge radove dobitnike Nobelove nagrade. Najznačajniji primjeri su radovi Erwina Nehera i Berta Sakmanna ”otkrića funkcija pojedinačnih ionskih kanala u stanicama” objavljenog 1976., te rad iz 2003., koji se bavi ”strukturnim i mehaničkim studijama ionskih kanala” autora Rodericka MacKinnona. Moglo bi se tvrditi da je to bila početna točka za stanićnu neurofiziologiju – široko podpolje neuroznanosti koje proučava neurone na staničnoj razini. U ovom diplomskom radu usredotočit ćemo se na rezultate Hodgkina i Huxleyija, kao i na niz različitih modela koji su iz njih proizašli te potaknuli stvaranje novih i atraktivnih smjerova istraživanja modela neurona. Takvi modeli su sve više prepoznati i od eksperimentalnih i teorijskih znanstvenika jer otvaraju mogućnosti za jedinstvena multidisciplinarna istraživanja i studijske programe. Less
Keywords
Keywords (english)
Languageenglish
URN:NBNurn:nbn:hr:105:664497
Study programmeTitle: Medicine (in English language)
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2022-12-21 12:14:38
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