'Acneiform eruptions' is an umbrella term that encompasses a number of skin disorders resembling acne vulgaris. Although both acne and acne-like dermatoses are frequently encountered in clinical practice, making a distinction might be challenging. As with acne, the follicular lesions of acneiform eruptions may present with papules, pustules, nodules, or cysts. However, clinical examination of acneiform eruptions fails to detect comedones, the absence of which serves as the key distinctive feature when identifying these lesions. Furthermore, acneiform eruptions can be separated from acne by their abrupt onset, occurrence in any age group, distributions beyond the seborrheic areas, and the monomorphic morphology of lesions. There is no sole mechanism that explains the development of acneiform eruptions; nevertheless, patients' age, occupation, habits, infections, cosmetics, medications, and various other factors may be implicated. The presenting lesions may be resistant to conventional acne therapy, and the treatment should be tailored according to the recognized offending agents. In the case of drug-induced acneiform eruptions, lesions usually resolve upon discontinuation of the culprit medication. This review article aims to present different entities of acneiform eruptions and provide insight into the differences between them and true acne. Acneiform eruptions in the pediatric and the adult population, infectious diseases resembling acne, occupational and environmental acneiform eruptions, and drug-induced acneiform eruptions are addressed in this paper. Knowledge about the epidemiology, pathophysiology, and clinical presentation of this group of dermatoses is fundamental for making an accurate diagnosis and providing comprehensive care.