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master's thesis
Uloga Cajal-Retziusovih stanica tijekom razvoja mozga
Zagreb: University of Zagreb, School of Medicine, 2022. urn:nbn:hr:105:171406
Brčić, Alojzija
University of Zagreb
School of Medicine
Department of Physiology and Immunology

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

Cite this document

Brčić, A. (2022). Uloga Cajal-Retziusovih stanica tijekom razvoja mozga (Master's thesis). Zagreb: University of Zagreb, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:171406

Brčić, Alojzija. "Uloga Cajal-Retziusovih stanica tijekom razvoja mozga." Master's thesis, University of Zagreb, School of Medicine, 2022. https://urn.nsk.hr/urn:nbn:hr:105:171406

Brčić, Alojzija. "Uloga Cajal-Retziusovih stanica tijekom razvoja mozga." Master's thesis, University of Zagreb, School of Medicine, 2022. https://urn.nsk.hr/urn:nbn:hr:105:171406

Brčić, A. (2022). 'Uloga Cajal-Retziusovih stanica tijekom razvoja mozga', Master's thesis, University of Zagreb, School of Medicine, accessed 30 December 2024, https://urn.nsk.hr/urn:nbn:hr:105:171406

Brčić A. Uloga Cajal-Retziusovih stanica tijekom razvoja mozga [Master's thesis]. Zagreb: University of Zagreb, School of Medicine; 2022 [cited 2024 December 30] Available at: https://urn.nsk.hr/urn:nbn:hr:105:171406

A. Brčić, "Uloga Cajal-Retziusovih stanica tijekom razvoja mozga", Master's thesis, University of Zagreb, School of Medicine, Zagreb, 2022. Available at: https://urn.nsk.hr/urn:nbn:hr:105:171406

Metadata
TitleUloga Cajal-Retziusovih stanica tijekom razvoja mozga
Title (english)The role of Cajal-Retzius cell during brain development
AuthorAlojzija Brčić
MentorŽeljka Krsnik (mentor)
Committee memberZdravko Petanjek (predsjednik povjerenstva)
Committee memberŽeljka Krsnik (član povjerenstva)
Committee memberGoran Šimić (član povjerenstva)
GranterUniversity of Zagreb
School of Medicine
(Department of Physiology and Immunology)
Zagreb
Defense date and country2022-09-02, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Clinical Immunology
Abstract
Razvoj moždanih struktura precizno je genski regulirano tijekom intrauterinog razdoblja. Fetalnu moždanu koru čine (od ventrikularne prema pijalnoj površini) ventrikularna zona, subventrikularna zona, intermedijalna zona, subplate zona, kortikalna ploča i marginalna zona. Cajal-Retziusove (CR) stanice, smještene u marginalnoj zoni moždane kore otkrivene su krajem 19. stoljeća, a njihov značaj u kortikogenezi istražuje se i danas. Riječ je o skupini prolaznih fetalnih stanica za koje se smatra da većinom prolaze proces stanične smrti u perinatalnom razdoblju. Cajal-Retziusove stanice izlučuju glikoprotein Reelin u izvanstanični prostor, uključen u regulaciju migracije neurona, a time i laminaciju moždane kore. Poremećaj u Reelinskoj signalizaciji može dovesti do poremećene migracije neurona, te posljedično do poremećene kortikalne laminacije. Bolesti za koje se smatra da postoji povezanost s poremećajem u Reelinskoj signalizaciji uključuju shizofreniju, autizam, Parkinsonovu bolest, bipolarni poremećaj, Alzheimerovu bolest, tuberoznu sklerozu i epilepsiju temporalnog režnja.
Abstract (english)
Development of the cerebral cortex has precise genetic regulation during an intrauterine period. In the fetal cerebral cortex, from the ventricular to the pial surface, transient fetal zones are ventricular zone, subventricular zone, intermediate zone, subplate zone, cortical plate and marginal zone. Cajal-Retzius cells, located in the cortical marginal zone were discovered at the end of the 19th century, and their significance in corticogenesis is still being researched. They are considered as a group of transient cells that mainly disappear by cell death in the perinatal period. Cajal-Retzius cells secrete the glycoprotein Reelin into the extracellular space involved in regulation of neuronal migration and cortical lamination. Disturbance in the Cajal-Retzius cells or the Reelin signaling leads to a disturbance in the migration of neurons and correct layering of the fetal cortex. Disorders such as schizophrenia, autism spectrum disorder, Parkinson's disease, bipolar disorder, Alzheimer's disease, tuberous sclerosis and temporal lobe epilepsy are also associated with disturbance in CR cells or Reelin signalling.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:105:171406
Study programmeTitle: Medicine
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2023-01-04 09:56:16