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master's thesis
Povezanost nesuglasja dijagnostičkih nalaza s ishodom kirurškog liječenja u pacijenata s ranim karcinomom glotisa
Zagreb: University of Zagreb, School of Medicine, 2022. urn:nbn:hr:105:958139
Geber, Antonela
University of Zagreb
School of Medicine
Department of Othorhinolaryngology and Head and Neck Surgery

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Geber, A. (2022). Povezanost nesuglasja dijagnostičkih nalaza s ishodom kirurškog liječenja u pacijenata s ranim karcinomom glotisa (Master's thesis). Zagreb: University of Zagreb, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:958139

Geber, Antonela. "Povezanost nesuglasja dijagnostičkih nalaza s ishodom kirurškog liječenja u pacijenata s ranim karcinomom glotisa." Master's thesis, University of Zagreb, School of Medicine, 2022. https://urn.nsk.hr/urn:nbn:hr:105:958139

Geber, Antonela. "Povezanost nesuglasja dijagnostičkih nalaza s ishodom kirurškog liječenja u pacijenata s ranim karcinomom glotisa." Master's thesis, University of Zagreb, School of Medicine, 2022. https://urn.nsk.hr/urn:nbn:hr:105:958139

Geber, A. (2022). 'Povezanost nesuglasja dijagnostičkih nalaza s ishodom kirurškog liječenja u pacijenata s ranim karcinomom glotisa', Master's thesis, University of Zagreb, School of Medicine, accessed 26 November 2024, https://urn.nsk.hr/urn:nbn:hr:105:958139

Geber A. Povezanost nesuglasja dijagnostičkih nalaza s ishodom kirurškog liječenja u pacijenata s ranim karcinomom glotisa [Master's thesis]. Zagreb: University of Zagreb, School of Medicine; 2022 [cited 2024 November 26] Available at: https://urn.nsk.hr/urn:nbn:hr:105:958139

A. Geber, "Povezanost nesuglasja dijagnostičkih nalaza s ishodom kirurškog liječenja u pacijenata s ranim karcinomom glotisa", Master's thesis, University of Zagreb, School of Medicine, Zagreb, 2022. Available at: https://urn.nsk.hr/urn:nbn:hr:105:958139

Metadata
TitlePovezanost nesuglasja dijagnostičkih nalaza s ishodom kirurškog liječenja u pacijenata s ranim karcinomom glotisa
Title (english)Correlation between Diagnostic Findings Mismatch and Surgical Outcome in Patients with Early Laryngeal Cancer
AuthorAntonela Geber
MentorAndro Košec (mentor)
Committee memberIvan Rašić (predsjednik povjerenstva)
Committee memberMihael Ries (član povjerenstva)
Committee memberAndro Košec (član povjerenstva)
GranterUniversity of Zagreb
School of Medicine
(Department of Othorhinolaryngology and Head and Neck Surgery)
Zagreb
Defense date and country2022-07-15, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Otorhinolaryngology
Abstract
Najzastupljeniji karcinom larinksa je planocelularni karcinom u području glotisa. Dijagnostička obrada karcinoma larinksa uključuje kompjutoriziranu tomografiju (CT), endoskopiju i biopsiju. Rani karcinomi larinksa podrazumijevaju T1- i T2-stadij. Cilj ovoga rada bio je identificirati čimbenike koji doprinose nesuglasju između nalaza CT-a te endoskopskih i patohistoloških nalaza, kao i čimbenike koji doprinose pojavi pozitivnih postoperativnih rubova i potrebi za postoperativnom radioterapijom u pacijenata s ranim karcinomima glotisa te ispitati njihovu podudarnost. U studiju je bio uključen 101 muškarac i 8 žena. Prema dobivenim rezultatima nepodudarnost nalaza CT-a i endoskopskog nalaza nađena je u 36 slučajeva, između endoskopskog i patohistološkog nalaza u 37 slučajeva, a između nalaza CT-a i patohistološkog nalaza u 38 slučajeva. Pozitivne rubove nakon kordektomije imalo je 14 pacijenta, a 16 pacijenata bilo je podvrgnuto radioterapiji. Zahvaćenost prednje komisure, širenje karcinoma u područje supraglotisa te umanjena klinička T-kategorija tumora prepoznati su kao čimbenici koji doprinose nesuglasju između dijagnostičkih nalaza, kao i pojavi pozitivnih rubova i potrebi za postoperativnom radioterapijom. Temeljem toga navedeni identificirani čimbenici omogućuju izdvajanje pacijenata s većim rizikom za lošiji ishod kirurškog liječenja.
Abstract (english)
The most common laryngeal carcinoma is squamous cell carcinoma placed in glottis. Diagnostic procedure of laryngeal carcinoma includes computed tomography (CT), endoscopy and biopsy. Early laryngeal carcinomas include stage T1 and T2. The main purpose of this research was to identify risk factors for mismatch between each diagnostic method, CT, endoscopic and patohistological findings as well as risk factors for positive margins and postoperative radiotherapy. In this study 101 male and 8 female patients were included. According to the results, mismatch between CT and endoscopic findings was found in 36 cases, mismatch between endoscopic and patohistological findings in 37 cases and mismatch between CT and patohistological findings in 38 cases. There were 14 cases with positive margins and 16 patients were treated with postoperative radiotherapy. CT positive for anterior commissure involvement, tumor extension into the supraglottis and endoscopic understaging were identified as risk factors for mismatch between diagnostic findings as well as risk factors for positive margins and postoperative radiotherapy. Therefore, those factors can be used to predict worse outcome of surgical treatment in patients with early laryngeal cancer.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:105:958139
Study programmeTitle: Medicine
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2023-01-09 08:45:37