The newborn age covers the first month of a child's life, and is marked by numerous changes in order to adapt the organism to extrauterine conditions. One of the more special features of the newborn is the immaturity of the immune system which makes it much easier for the newborn to become infected either intrauterinely, during childbirth or postpartum. Any infection in a newborn baby has the potential to progress and spread to sepsis. The incidence of neonatal sepsis ranges from 1 to 10 per 1000 newborns. Sepsis is characterized by a systemic inflammatory response of an organism to a pathogen and can lead to a life-threatening condition such as septic shock, which still has a high mortality in the newborn. Neonatal sepsis is divided into early and late depending on the time of onset. Early neonatal sepsis occurs within the first three days of a child's life, and is most often caused by a child's perinatal infection during birth and is also associated with a birth complication. The most common causes are BHS-B and E.coli. Late neonatal sepsis occurs after day 7 of life and is caused mainly by some of the nosocomial pathogens such as P.aeruginosa, Klebsisella, E.coli, fungi, and even some viruses. Criteria for diagnosing neonatal sepsis are defined by body temperature abnormalities, the occurrence of tachycardia / bradycardia, accelerated respiratory rate, and laboratory signs such as abnormalities in leukocyte counts and the appearance of immature forms of neutrophils. Clinical signs, although nonspecific, can serve us in the early recognition and initiation of treatment of sepsis in the newborn. The child may present with use of auxiliary muscles during breathing, aponic episodes, tachypnea, heart rhythm disorders, difficulty sucking and refusing food, diarrhea and vomiting, jaundice. Signs such as sclereme or marbling of the skin may occur on the skin which may be an alarming sign. Disorders of consciousness, hypoactivity of the child, disorders of body temperature regulation and bulging fontanelle are most common on the part of the neurological system, and in addition metabolic changes in the form of hyper / hypoglycemia, electrolyte and acid-base disorders are most often expected in the form of acidosis.