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master's thesis
Inzulinska signalizacija u hipokampusu modela Alzheimerove bolesti u transgeničnih miševa
Zagreb: University of Zagreb, School of Medicine, 2022. urn:nbn:hr:105:123262
Kovač, Diana
University of Zagreb
School of Medicine
Department of Pharmacology

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

Cite this document

Kovač, D. (2022). Inzulinska signalizacija u hipokampusu modela Alzheimerove bolesti u transgeničnih miševa (Master's thesis). Zagreb: University of Zagreb, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:123262

Kovač, Diana. "Inzulinska signalizacija u hipokampusu modela Alzheimerove bolesti u transgeničnih miševa." Master's thesis, University of Zagreb, School of Medicine, 2022. https://urn.nsk.hr/urn:nbn:hr:105:123262

Kovač, Diana. "Inzulinska signalizacija u hipokampusu modela Alzheimerove bolesti u transgeničnih miševa." Master's thesis, University of Zagreb, School of Medicine, 2022. https://urn.nsk.hr/urn:nbn:hr:105:123262

Kovač, D. (2022). 'Inzulinska signalizacija u hipokampusu modela Alzheimerove bolesti u transgeničnih miševa', Master's thesis, University of Zagreb, School of Medicine, accessed 22 November 2024, https://urn.nsk.hr/urn:nbn:hr:105:123262

Kovač D. Inzulinska signalizacija u hipokampusu modela Alzheimerove bolesti u transgeničnih miševa [Master's thesis]. Zagreb: University of Zagreb, School of Medicine; 2022 [cited 2024 November 22] Available at: https://urn.nsk.hr/urn:nbn:hr:105:123262

D. Kovač, "Inzulinska signalizacija u hipokampusu modela Alzheimerove bolesti u transgeničnih miševa", Master's thesis, University of Zagreb, School of Medicine, Zagreb, 2022. Available at: https://urn.nsk.hr/urn:nbn:hr:105:123262

Metadata
TitleInzulinska signalizacija u hipokampusu modela Alzheimerove bolesti u transgeničnih miševa
Title (english)Insulin signaling in the hippocampus of the transgenic mouse model of Alzheimer's disease
AuthorDiana Kovač
MentorJelena Osmanović Barilar (mentor)
Committee memberMelita Šalković-Petrišić (predsjednik povjerenstva)
Committee memberJasenka Markeljević (član povjerenstva)
Committee memberJelena Osmanović Barilar (član povjerenstva)
GranterUniversity of Zagreb
School of Medicine
(Department of Pharmacology)
Zagreb
Defense date and country2022-07-15, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Pharmacology
Abstract
Alzheimerova bolest je progresivni neurodegenerativni poremećaj koji dovodi do ireverzibilnih promjena mozga s posljedičnim djelovanjem na pamćenje, ponašanje i osobnost. Glavna patološka obilježja bolesti su: ekstracelularno nakupljanje amiloidnih plakova te formiranje neurofibrilarnih vretena potaknuto hiperfosforilacijom tau proteina. Razlikujemo dva oblika ove bolesti: sporadični i familijarni oblik. U ovom istraživanju korišteni su transgenični Tg2576 miševi koji predstavljaju model familijarnog oblika Alzheimerove bolesti (fAB). Ispitani su učinci APP-transgeničnosti i starenja u predsimptomatskom i blagom stadiju bolesti. Izmjerena je ekspresija proteina inzulinske signalizacije (IRS, pIRS, PI3K, CDK5, TAU, pTAU, CAMKII i pCAMKII) u hipokampusu u dvije starosne skupine miševa 7 i 12 mjeseci. Naši rezultati ukazuju na postojanje biokemijskih promjena u hipokampusu između dvije različite starosne skupine miševa te ukazuju na važnost odabira odgovarajućeg modela obzirom na dob životinja prilikom provođenja istraživanja.
Abstract (english)
Alzheimer's disease is a progressive neurodegenerative disorder that leads to irreversible brain changes with consequent effects on memory, behavior and personality. The main pathological features of the disease are an extracellular accumulation of amyloid plaques and the formation of neurofibrillary tangles induced by hyperphosphorylation of tau protein. There are two forms of this disease: sporadic and familial. Transgenic Tg2576 mice representing the familial form of Alzheimer's disease (fAB) were used in this study. The effects of APP-transgenicity and aging in the pre-symptomatic and mild stages of the disease were examined. The expression of insulin signaling proteins (IRS, pIRS, PI3K, CDK5, TAU, pTAU, CAMKII, and pCAMKII) was measured in the hippocampus in two age groups of mice, 7 and 12 months. Our results indicate the existence of biochemical changes in the hippocampus between two different age groups of mice indicate the importance of choosing the appropriate age-model when conducting a research.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:105:123262
ProjectNumber: IP-2014-09-4639
Title: TERAPIJSKI POTENCIJAL ORALNE GALAKTOZE U EKSPERIMENTALNOJ ALZHEIMEROVOJ BOLESTI
Title: THERAPEUTIC POTENTIAL OF ORAL GALACTOSE IN EXPERIMENTAL ALZHEIMER'S DISEASE
Acronym: GALAD
Leader: Petrišić Melita Šalković
Jurisdiction: Croatia
Funder: HRZZ
Funding stream: IP
Study programmeTitle: Medicine
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2023-01-13 10:25:39