Myasthenia gravis (MG) is an acquired autoimmune disease which occurs from the production of antibodies targeting the acetylcholine receptors on the motor end plate, thereby disrupting signal transmission of neuromuscular junction. Even though the exact cause is still unknown, MG is considered to have multifactorial etiology. The age distribution of MG that reaches its peak in the female's reproductive age indicates the need for enhanced preconceptional, antenatal and postpartum care. According to the distribution of symptoms, MG is classified into the ocular MG with the development of ptosis and diplopia and the generalized MG which includes extraocular muscles weakness. Myasthenic crisis with respiratory failure presents urgent neurological condition and is frequently provoked during pregnancy and postpartum period. The diagnosis is based on medical history, physical examination, serology, and additional pharmacological and electrophysiological testing. Treatment includes acetylcholinesterase inhibitors, immunosuppressive therapy, thymectomy, intravenous immunoglobulins and plasmapheresis. Preconception counseling is mandatory in an attempt to ensure disease control and to prevent teratogenic effect of immunosuppressants at the same time. Pregnancy has various effects on the course of the disease. Remission and exacerbation are possible while the severity of the disease may remain unchanged. Antenatal care includes regular pulmonary function tests, individual dose adjustment and fetal ultrasound to determine fetal movements. Due to hemodynamic changes during pregnancy, drug dose adjustment and deciding on a safe therapy in pregnancy can be very challenging. Spontaneous vaginal delivery under epidural anesthesia is usually encouraged while choosing the mode of delivery. Breastfeeding is recommended with continuous monitoring of the newborn and mother due to the possibility of postpartum exacerbation in 30% of the cases. Transient neonatal myasthenia gravis (TNMG) occurs as a result of transplacental transmission of maternal antibodies and is recognized within the first 12-48 h when it is important to monitor the quality of respiration.